PMID- 36372063
OWN - NLM
STAT- MEDLINE
DCOM- 20230223
LR  - 20230225
IS  - 1532-7914 (Electronic)
IS  - 0163-5581 (Linking)
VI  - 75
IP  - 2
DP  - 2023
TI  - Effects of Polyunsaturated Fatty Acids on Colorectal Cancer Patients: A 
      Meta-Analysis of Randomized Controlled Trials.
PG  - 627-639
LID - 10.1080/01635581.2022.2145319 [doi]
AB  - This study aimed to investigate the effects of polyunsaturated fatty acids 
      (PUFAs) on patients with colorectal cancer (CRC). Electronic databases such as 
      PubMed and Web of Science were searched. Studies on the application of PUFAs in 
      patients with CRC, published up to January 2022, were conducted. Twelve studies 
      involving 702 CRC patients were included. For patients undergoing surgery, 
      subgroup analyses indicated that preoperative supplementation with PUFAs improved 
      total postoperative infectious complications (RR: 0.37, p = 0.02). Furthermore, 
      the supplementation of PUFAs in preoperative (WMD: -2.27, p < 0.001) and 
      postoperative (WMD: -2.66, p = 0.01) groups was effective in shortening the 
      postoperative hospital stay for patients with CRC. Tumor necrosis factor-alpha 
      (TNF-alpha) (SMD: -0.56, p = 0.007) and interleukin-6 (IL-6) (SMD: -0.54, p = 0.004) 
      levels were lower in all CRC patients receiving PUFAs intervention than in the 
      control group. Moreover, supplementation with PUFAs in chemotherapy patients 
      significantly increased albumin (WMD: 0.48, p = 0.03) and decreased C-reactive 
      protein (CRP) (WMD: -6.12, p = 0.02) compared to the control group. This study 
      demonstrated that PUFAs intervention could diminish the total postoperative 
      infection complications of CRC patients, shorten the postoperative hospital stay, 
      and reduce inflammation.
FAU - Li, Lingna
AU  - Li L
AD  - Pharmacy Department, The Affiliated Hospital of Ningbo University, LiHuiLi 
      Hospital, Ningbo, China.
FAU - Wang, Dongying
AU  - Wang D
AD  - The First Clinical Medical College, Zhejiang Chinese Medical University, 
      Hangzhou, China.
FAU - He, Ning
AU  - He N
AD  - Department of Tumor HIFU Therapy, Ningbo No. 2 Hospital, Ningbo, China.
FAU - Dai, Senjie
AU  - Dai S
AD  - The Second Clinical Medical College, Zhejiang Chinese Medical University, 
      Hangzhou, China.
FAU - Tu, Leling
AU  - Tu L
AD  - The First Clinical Medical College, Zhejiang Chinese Medical University, 
      Hangzhou, China.
FAU - Fu, Rongrong
AU  - Fu R
AD  - The First Clinical Medical College, Zhejiang Chinese Medical University, 
      Hangzhou, China.
FAU - Chen, Ping
AU  - Chen P
AD  - Department of General Surgery, Ningbo No. 2 Hospital, Ningbo, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221113
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Unsaturated)
SB  - IM
MH  - Humans
MH  - *Fatty Acids, Omega-3/therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Fatty Acids, Unsaturated
MH  - Inflammation/drug therapy
MH  - *Colorectal Neoplasms/drug therapy/surgery
MH  - Dietary Supplements
EDAT- 2022/11/14 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/11/13 18:35
PHST- 2022/11/14 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/11/13 18:35 [entrez]
AID - 10.1080/01635581.2022.2145319 [doi]
PST - ppublish
SO  - Nutr Cancer. 2023;75(2):627-639. doi: 10.1080/01635581.2022.2145319. Epub 2022 
      Nov 13.