PMID- 36372866
OWN - NLM
STAT- MEDLINE
DCOM- 20230201
LR  - 20230313
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 270
IP  - 2
DP  - 2023 Feb
TI  - Optical coherence tomography as a prognostic tool for disability progression in 
      MS: a systematic review.
PG  - 1178-1186
LID - 10.1007/s00415-022-11474-4 [doi]
AB  - Since multiple sclerosis (MS) is characterized by an unpredictable disease 
      course, accurate prognosis and personalized treatment constitute an important 
      challenge in clinical practice. We performed a qualitative systematic review to 
      assess the predictive value of retinal layer measurement by spectral-domain 
      optical coherence tomography (SD-OCT) in MS patients. Longitudinal MS cohort 
      studies that determined the risk of clinical deterioration based on peripapillary 
      retinal nerve fiber layer (pRNFL) and/or macular ganglion cell-inner plexiform 
      layer (mGCIPL) atrophy were included. Our search strategy and selection process 
      yielded eight articles in total. Of those, five studies only focused on patients 
      with a relapsing-remitting disease pattern (RRMS). After correction for 
      confounders such as disease duration, we found that (1) cross-sectional 
      measurement of pRNFL thickness </= 88 microm; (2) cross-sectional measurement of mGCIPL 
      thickness < 77 microm; (3) longitudinal measurement of pRNFL thinning > 1.5 microm/year; 
      and (4) longitudinal measurement of mGCIPL thinning >/= 1.0 microm/year is associated 
      with an increased risk for disability progression in subsequent years. 
      Longitudinal mGCIPL assessment consistently resulted in the highest risk 
      estimates in our analysis. Within these studies, inclusion and exclusion criteria 
      accounted for the retinal degeneration inherent to (acute) optic neuritis (ON). 
      This small systematic review provides additional evidence that OCT-measured pRNFL 
      and/or mGCIPL atrophy can predict disability progression in RRMS patients. We 
      therefore recommend close clinical follow-up or initiation/change of treatment in 
      RRMS patients with increased risk for clinical deterioration based on retinal 
      layer thresholds, in particular when other poor prognostic signs co-occur.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Swinnen, Stijn
AU  - Swinnen S
AUID- ORCID: 0000-0003-1028-197X
AD  - Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain 
      Institute, Leuven, Belgium.
AD  - Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, 
      Leuven, Belgium.
FAU - De Wit, Dries
AU  - De Wit D
AD  - Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain 
      Institute, Leuven, Belgium.
AD  - Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, 
      Leuven, Belgium.
FAU - Van Cleemput, Liesbeth
AU  - Van Cleemput L
AD  - Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
FAU - Cassiman, Catherine
AU  - Cassiman C
AD  - Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
FAU - Dubois, Benedicte
AU  - Dubois B
AUID- ORCID: 0000-0003-0604-8702
AD  - Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain 
      Institute, Leuven, Belgium. benedicte.dubois@uzleuven.be.
AD  - Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, 
      Leuven, Belgium. benedicte.dubois@uzleuven.be.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20221113
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - Tomography, Optical Coherence/methods
MH  - *Clinical Deterioration
MH  - Cross-Sectional Studies
MH  - *Multiple Sclerosis/diagnostic imaging/complications
MH  - *Retinal Degeneration
MH  - *Macular Degeneration
MH  - Atrophy/complications
OTO - NOTNLM
OT  - Disease progression
OT  - Multiple sclerosis (MS)
OT  - Optical coherence tomography (OCT)
OT  - Prognosis
OT  - Retinal layer measurement
EDAT- 2022/11/15 06:00
MHDA- 2023/02/02 06:00
CRDT- 2022/11/14 00:03
PHST- 2022/10/05 00:00 [received]
PHST- 2022/10/30 00:00 [accepted]
PHST- 2022/11/15 06:00 [pubmed]
PHST- 2023/02/02 06:00 [medline]
PHST- 2022/11/14 00:03 [entrez]
AID - 10.1007/s00415-022-11474-4 [pii]
AID - 10.1007/s00415-022-11474-4 [doi]
PST - ppublish
SO  - J Neurol. 2023 Feb;270(2):1178-1186. doi: 10.1007/s00415-022-11474-4. Epub 2022 
      Nov 13.