PMID- 36372919
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20230601
IS  - 2212-3873 (Electronic)
IS  - 1871-5303 (Linking)
VI  - 23
IP  - 6
DP  - 2023
TI  - Role of HLA-DPrs3077 and HLA-DQrs3920 Polymorphisms as Risk Factors for Type 1 
      Diabetes Mellitus.
PG  - 850-856
LID - 10.2174/1871530323666221111153102 [doi]
AB  - BACKGROUND: Type 1 diabetes mellitus (T1DM) is a chronic disease caused by the 
      destruction of insulin-producing pancreatic beta-cells. During disease progression, 
      inflammatory insulitis increases the presentation of islet antigens on human 
      leukocyte antigen (HLA) molecules to T lymphocytes. This complex system plays a 
      pivotal role in cellular immunity. Thus, genetic variability in HLA can affect 
      the susceptibility to and clinical outcomes of DM. AIM: This case-control study 
      aimed to assess the role of HLA-DP-rs3077 (A/G) and HLA-DQrs3920 (A/G) 
      polymorphism in T1DM. SUBJECTS AND METHODS: This study enrolled 400 individuals: 
      200 patients with T1DM and 200 ageand sex-matched healthy controls. Hemoglobin 
      A1C and random, fasting, and postprandial blood sugar levels were determined for 
      all subjects. Genotypic and allelic distributions of HLA-DPrs3077 (A/G) and 
      HLA-DQrs3920 (A/G) SNPs were determined using real-time polymerase chain reaction 
      (PCR). RESULTS: Frequency of the HLA-DPrs3077A allele was high among the diabetic 
      group (91.3%); however, the difference was non-significant [OR (95% C.I) = 
      1.422(0.89-2.252), P=0.098]. The frequency of the HLA-DQrs3920 GG genotype was 
      higher in control than the diabetic group (52.5% vs.12%), whereas that of the AA 
      genotype was higher in the person with diabetes than in the control group (34% 
      vs.4%). Individuals carrying the HLA-DQrs3920A allele were 4.5 times more likely 
      to have T1DM than those carrying the G allele [OR (95% C.I) = 4.510 (3.338- 
      6.094), P<0.001*]. The presence of HLA-DPrs3077A and HLA-DQ rs3920A in the same 
      person increases T1DM risk by 3.6 times that of G allele [OR (95%C.I) = 
      3.608(2.173-5.991), P<0.001*]. CONCLUSION: HLA-DPrs3077 and HLA-DQrs3920 SNPs 
      have a role in T1DM as the coexistence of HLA-DPrs3077A and HLA-DQrs3920A alleles 
      increases the risk.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Ghazy, Amany A
AU  - Ghazy AA
AD  - Microbiology and Medical Immunology Unit, Department of Pathology, College of 
      Medicine, Jouf University, Saudi Arabia.
LA  - eng
GR  - DSR-2021-01-03167/Al Jouf University/
PT  - Journal Article
PL  - United Arab Emirates
TA  - Endocr Metab Immune Disord Drug Targets
JT  - Endocrine, metabolic & immune disorders drug targets
JID - 101269157
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 1/diagnosis/epidemiology/genetics
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Risk Factors
MH  - HLA Antigens
MH  - Genotype
MH  - Polymorphism, Single Nucleotide/genetics
OTO - NOTNLM
OT  - HLA-D
OT  - HLA-DQ-rs3920SNP
OT  - Prs3077
OT  - SNP
OT  - T1DM
OT  - genotype
EDAT- 2022/11/15 06:00
MHDA- 2023/06/01 06:42
CRDT- 2022/11/14 00:06
PHST- 2022/07/02 00:00 [received]
PHST- 2022/10/11 00:00 [revised]
PHST- 2022/10/18 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2022/11/15 06:00 [pubmed]
PHST- 2022/11/14 00:06 [entrez]
AID - EMIDDT-EPUB-127524 [pii]
AID - 10.2174/1871530323666221111153102 [doi]
PST - ppublish
SO  - Endocr Metab Immune Disord Drug Targets. 2023;23(6):850-856. doi: 
      10.2174/1871530323666221111153102.