PMID- 36374146
OWN - NLM
STAT- MEDLINE
DCOM- 20221116
LR  - 20230209
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Print)
IS  - 1220-0522 (Linking)
VI  - 63
IP  - 2
DP  - 2022 Apr-Jun
TI  - Allergic rhinitis associated with nasal polyps and rhinosinusitis - 
      histopathological and immunohistochemical study.
PG  - 413-419
LID - 10.47162/RJME.63.2.12 [doi]
AB  - Currently, allergic rhinitis (AR) is the most common allergic disease worldwide. 
      AR is defined as immunoglobulin E (IgE)-mediated chronic inflammatory disease of 
      the upper airways. It characterizes by symptoms like nasal obstruction, 
      rhinorrhea, nasal itching, and sneezing. The immune system and genetic 
      susceptibility in the interaction with the environment lead to the development of 
      AR. Many cytokines, chemokines and cells maintain allergic inflammation. Studies 
      show that 10% to 30% of the adult population are affected, and that prevalence 
      rates are increasing world widely. AR, nasal polyps (NP), as well as chronic 
      rhinosinusitis (CRS) are all associated with eosinophilic infiltration and large 
      quantities of mast cells (MCs) within the mucosa. The diagnosis and management of 
      chronic sinonasal diseases involves the analysis of eosinophilic infiltration, 
      MCs, and their markers eosinophilic cationic protein (ECP) and tryptase. 
      Regarding nasal cancer, nasal allergies were found to exhibit a dual function: 
      immune surveillance may help in the defense against malignant cells, but an 
      opposite effect is observed in tissues with chronic stimulation and inflammation. 
      In the present paper, we studied a group of 70 patients diagnosed with AR and NP, 
      rhinosinusitis or nasal cancer, admitted to the Ear, Nose & Throat (ENT) Clinic 
      of the Emergency City Hospital, Timisoara, Romania, between January 2016 and 
      December 2020, and we identified 37 (53%) patients diagnosed with AR and NP, 25 
      (36%) patients diagnosed with AR and rhinosinusitis, and eight (11%) patients 
      diagnosed with AR and nasal cancer. The average age of the patients was 53 years 
      old. Every patient included in the study was histopathologically and 
      immunohistochemically diagnosed.
FAU - Iordache, Andreea
AU  - Iordache A
AD  - Department of ENT, Victor Babes University of Medicine and Pharmacy, Timisoara, 
      Romania; giovanescu@gmail.com; Department of Sports and Health, Constantin 
      Brancusi University, Targu Jiu, Romania; bogdanniculescu78@yahoo.com.
FAU - Balica, Nicolae Constantin
AU  - Balica NC
FAU - Horhat, Ioana Delia
AU  - Horhat ID
FAU - Morar, Raluca
AU  - Morar R
FAU - Tischer, Alina Andreea
AU  - Tischer AA
FAU - Milcu, Adina Iuliana
AU  - Milcu AI
FAU - Salavat, Madalina Casiana
AU  - Salavat MC
FAU - Boruga, Veronica Madalina
AU  - Boruga VM
FAU - Niculescu, Bogdan
AU  - Niculescu B
FAU - Iovanescu, Gheorghe
AU  - Iovanescu G
FAU - Popa, Zoran Laurentiu
AU  - Popa ZL
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
SB  - IM
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - *Nasal Polyps/complications/pathology
MH  - *Nose Neoplasms/pathology
MH  - *Sinusitis/complications/pathology
MH  - *Rhinitis, Allergic/complications/metabolism
MH  - Chronic Disease
MH  - Inflammation/pathology
MH  - Nasal Mucosa/pathology
PMC - PMC9801672
COIS- The authors declare that they have no conflict of interests.
EDAT- 2022/11/15 06:00
MHDA- 2022/11/18 06:00
PMCR- 2022/04/01
CRDT- 2022/11/14 09:32
PHST- 2022/11/14 09:32 [entrez]
PHST- 2022/11/15 06:00 [pubmed]
PHST- 2022/11/18 06:00 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 630222413419 [pii]
AID - 630122253259 [pii]
AID - 10.47162/RJME.63.2.12 [doi]
PST - ppublish
SO  - Rom J Morphol Embryol. 2022 Apr-Jun;63(2):413-419. doi: 10.47162/RJME.63.2.12.