PMID- 36375897 OWN - NLM STAT- MEDLINE DCOM- 20221116 LR - 20221116 IS - 1001-0742 (Print) IS - 1001-0742 (Linking) VI - 125 DP - 2023 Mar TI - Short-term impacts of air pollution on the platelet-lymphocyte ratio and neutrophil-lymphocyte ratio among urban adults in China. PG - 101-111 LID - S1001-0742(21)00439-3 [pii] LID - 10.1016/j.jes.2021.10.022 [doi] AB - The short-term impacts of urban air pollution on the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) remain obscure. In this study, we included 3487 urban adults from the Wuhan-Zhuhai cohort. Individual inhalation exposure to air pollutants was estimated by combining participants' daily breath volume and ambient concentrations of six air pollutants (including fine particulate matter (PM(2.5)), inhalable particulate matter (PM(10)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), carbon monoxide (CO) and ozone (O(3))). The cumulative impacts were assessed by applying lag structures of up to 7 days before the survey date. Associations of air pollutants with PLR and NLR were assessed using a linear mixed model and Bayesian kernel machine regression (BKMR) model. We found that PLR was negatively related to PM(2.5) (lag02-lag06), PM(10) (lag02-lag07), NO(2) (lag02-lag07), and SO(2) (lag03-lag05) and NLR was negatively related to PM(10) (lag05 and lag07). In the BKMR model, a negative joint association between the six-air-pollutant mixture and PLR and NLR was observed, whereas PM(10) and NO(2) appeared to be more important than the other pollutants in the mixture. The negative impact of air pollutants was stronger in males, participants with lower body mass index (< 24 kg/m(2)), those cooking meals at home, drinkers, and non-exercisers. In conclusion, short-term exposure to air pollutants is significantly related to PLR and NLR in peripheral blood. PLR and NLR may provide new insight into the molecular mechanism underlying the adverse health impact of air pollutants. CI - Copyright (c) 2021. Published by Elsevier B.V. FAU - Qiu, Weihong AU - Qiu W AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - He, Heng AU - He H AD - Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Wang, Bin AU - Wang B AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Wang, Dongming AU - Wang D AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Mu, Ge AU - Mu G AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Xu, Tao AU - Xu T AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Zhou, Min AU - Zhou M AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Ye, Zi AU - Ye Z AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Ma, Jixuan AU - Ma J AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Chen, Weihong AU - Chen W AD - Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: wchen@mails.tjmu.edu.cn. LA - eng PT - Journal Article DEP - 20220203 PL - Netherlands TA - J Environ Sci (China) JT - Journal of environmental sciences (China) JID - 100967627 RN - S7G510RUBH (Nitrogen Dioxide) RN - 0 (Air Pollutants) RN - 0 (Particulate Matter) RN - 66H7ZZK23N (Ozone) RN - 0UZA3422Q4 (Sulfur Dioxide) SB - IM MH - Humans MH - Adult MH - Male MH - Nitrogen Dioxide/analysis MH - Neutrophils/chemistry MH - Bayes Theorem MH - *Air Pollution MH - *Air Pollutants/analysis MH - Particulate Matter/analysis MH - *Ozone/analysis MH - Sulfur Dioxide/analysis MH - China MH - Lymphocytes MH - Environmental Exposure/analysis OTO - NOTNLM OT - Air pollution OT - Inflammatory factor OT - Neutrophil-lymphocyte ratio (NLR) OT - Platelet-lymphocyte ratio (PLR) EDAT- 2022/11/15 06:00 MHDA- 2022/11/18 06:00 CRDT- 2022/11/14 21:05 PHST- 2021/03/08 00:00 [received] PHST- 2021/10/15 00:00 [revised] PHST- 2021/10/15 00:00 [accepted] PHST- 2022/11/14 21:05 [entrez] PHST- 2022/11/15 06:00 [pubmed] PHST- 2022/11/18 06:00 [medline] AID - S1001-0742(21)00439-3 [pii] AID - 10.1016/j.jes.2021.10.022 [doi] PST - ppublish SO - J Environ Sci (China). 2023 Mar;125:101-111. doi: 10.1016/j.jes.2021.10.022. Epub 2022 Feb 3.