PMID- 36376250
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230415
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Print)
IS  - 0001-690X (Linking)
VI  - 147
IP  - 2
DP  - 2023 Feb
TI  - White matter microstructure in habit and reward circuits in anorexia nervosa: 
      Insights from a neurite orientation dispersion and density imaging study.
PG  - 134-144
LID - 10.1111/acps.13521 [doi]
AB  - BACKGROUND: Behavioral features of anorexia nervosa (AN) suggest abnormalities in 
      reward and habit. Neuroimaging evidence suggests morphometric and functional 
      perturbations within these circuits, although fewer studies have assessed white 
      matter characteristics in AN, and no studies to date have assessed white matter 
      microstructure in AN. METHODS: In this brain imaging study, 29 female adolescents 
      with partially or fully weight-restored AN and 27 healthy controls, all between 
      10 and 19 years, underwent whole-brain multi-shell diffusion tensor imaging. 
      Utilizing neurite orientation dispersion and density imaging methods, we 
      investigated group differences in white matter neurite density, orientation 
      dispersion, and myelin density in tracts between prominent nodes of the reward 
      circuit (ventral tegmental area (VTA) to nucleus accumbens (NAcc)) and the habit 
      circuit (sensory motor area [SMA] to putamen). RESULTS: Findings revealed reduced 
      neurite (F = 5.20, p = 0.027) and myelin density (F = 5.39, p = 0.025) in the 
      left VTA-NAcc tract, and reduced orientation dispersion in the left (F = 7.00, 
      p = 0.011) and right (F = 6.77, p = 0.012) VTA-NAcc tract. There were no 
      significant group differences in the SMA-putamen tract. Significant 
      relationships, after corrections, were not evident between tract microstructure 
      and reward responsiveness, compulsive behaviors, illness duration, or BMI. 
      CONCLUSIONS: Adolescents with AN exhibit less dense, undermyelinated, and less 
      dispersed white matter tracts connecting prominent reward system nodes, which 
      could potentially signify underutilization of this part of the reward circuit. 
      These results provide a detailed examination of white matter microstructure in 
      tracts underlying instrumental behavioral phenotypes contributing to illness in 
      AN.
CI  - (c) 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons 
      Ltd.
FAU - Murray, Stuart B
AU  - Murray SB
AUID- ORCID: 0000-0002-5588-2915
AD  - Department of Psychiatry & Behavioral Sciences, University of Southern 
      California, Los Angeles, California, USA.
FAU - Cabeen, Ryan P
AU  - Cabeen RP
AUID- ORCID: 0000-0002-1372-3588
AD  - Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of 
      Medicine of USC, University of Southern California, Los Angeles, California, USA.
FAU - Jann, Kay
AU  - Jann K
AUID- ORCID: 0000-0003-3574-0538
AD  - Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of 
      Medicine of USC, University of Southern California, Los Angeles, California, USA.
FAU - Tadayonnejad, Reza
AU  - Tadayonnejad R
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California, 
      Los Angeles, California, USA.
AD  - Computation & Neural Systems program, California Institute of Technology, 
      Pasadena, California, USA.
FAU - Strober, Michael
AU  - Strober M
AUID- ORCID: 0000-0001-9134-317X
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California, 
      Los Angeles, California, USA.
FAU - Feusner, Jamie D
AU  - Feusner JD
AUID- ORCID: 0000-0002-0391-345X
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California, 
      Los Angeles, California, USA.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
LA  - eng
GR  - K23 MH115184/MH/NIMH NIH HHS/United States
GR  - R01 MH105662/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20221124
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
SB  - IM
MH  - Female
MH  - Humans
MH  - *White Matter/diagnostic imaging
MH  - Neurites
MH  - Diffusion Tensor Imaging/methods
MH  - *Anorexia Nervosa/diagnostic imaging
MH  - Brain
MH  - Habits
MH  - Reward
PMC - PMC9852024
MID - NIHMS1849568
OTO - NOTNLM
OT  - anorexia nervosa
OT  - eating disorders
OT  - neurite orientatio dispersion density imaging
OT  - white matter
COIS- The authors all declare that they have no competing interests.
EDAT- 2022/11/15 06:00
MHDA- 2023/01/24 06:00
PMCR- 2023/04/13
CRDT- 2022/11/14 22:42
PHST- 2022/11/01 00:00 [received]
PHST- 2022/11/04 00:00 [accepted]
PHST- 2022/11/15 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
PHST- 2022/11/14 22:42 [entrez]
PHST- 2023/04/13 00:00 [pmc-release]
AID - ACPS13521 [pii]
AID - 10.1111/acps.13521 [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2023 Feb;147(2):134-144. doi: 10.1111/acps.13521. Epub 2022 
      Nov 24.