PMID- 36378002
OWN - NLM
STAT- MEDLINE
DCOM- 20221118
LR  - 20221118
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 68
IP  - 11
DP  - 2022 Nov 1
TI  - Cytokine Levels in Patients with beta-Thalassemia Major and Healthy Individuals: a 
      Systematic Review and Meta-Analysis.
LID - 10.7754/Clin.Lab.2022.220142 [doi]
AB  - BACKGROUND: Cytokine levels in patients with beta-thalassemia major (beta-TM) have been 
      assessed in several studies. Accordingly, a wide variety of immune disturbances 
      has been shown in patients with thalassemia. Recurrent transfusions cause iron 
      overload, which induces an increase in the production of cytokines. However, no 
      systematic approach or meta-analysis has been done to provide a clear feature of 
      cytokine levels in beta-TM. The present meta-analysis aimed to summarize the 
      existing evidence regarding different levels of cytokines in patients with Beta-TM 
      compared to healthy controls. METHODS: This study was performed according to the 
      PRISMA checklist. A systematic search was done in Web of Science (ISI), Scopus, 
      and PubMed databases. The quality of the included studies was assessed based on 
      the New-castle-Ottawa Scale. Meta-analysis was run via STATA 13 software. The 
      standardized mean difference was considered the effect size for comparing the 
      continuous variables. RESULTS: This meta-analysis included 16 studies conducted 
      on 805 beta-TM patients and 624 healthy individuals (with the mean age of 16.10 +/- 
      4.33 and 16.22 +/- 3.78, respectively). The results showed significantly higher 
      levels of Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-6 (IL-6), and IL-10 in 
      patients with beta-TM compared to the healthy controls. CONCLUSION: The results 
      indicated that the levels of both inflammatory and anti-inflammatory cytokines 
      were higher in patients with beta-TM compared to the healthy population, which could 
      be associated with higher levels of oxidative markers in these patients. Further 
      studies are suggested to evaluate the difference in cytokine levels among 
      different types of thalassemia.
FAU - Haghpanah, Sezaneh
AU  - Haghpanah S
FAU - Hosseini-Bensenjan, Mahnaz
AU  - Hosseini-Bensenjan M
FAU - Sayadi, Mehrab
AU  - Sayadi M
FAU - Nozari, Farnoosh
AU  - Nozari F
FAU - Ramzi, Mani
AU  - Ramzi M
FAU - Cohan, Nader
AU  - Cohan N
FAU - Rezaei, Nima
AU  - Rezaei N
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - *beta-Thalassemia/complications
MH  - Cytokines
MH  - *Iron Overload
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
EDAT- 2022/11/16 06:00
MHDA- 2022/11/19 06:00
CRDT- 2022/11/15 09:25
PHST- 2022/11/15 09:25 [entrez]
PHST- 2022/11/16 06:00 [pubmed]
PHST- 2022/11/19 06:00 [medline]
AID - 10.7754/Clin.Lab.2022.220142 [doi]
PST - ppublish
SO  - Clin Lab. 2022 Nov 1;68(11). doi: 10.7754/Clin.Lab.2022.220142.