PMID- 36379285
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221221
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 223
IP  - Pt A
DP  - 2022 Dec 31
TI  - A new chitosan-based thermosensitive nanoplatform for combined photothermal and 
      chemotherapy.
PG  - 1356-1367
LID - S0141-8130(22)02626-5 [pii]
LID - 10.1016/j.ijbiomac.2022.11.068 [doi]
AB  - Targeting the delivery of anti-cancer drugs to a tumor site is essential for 
      effective treatment and to ensure minimal damage to healthy cells and tissues. In 
      this work, a chitosan-based nanoplatform was constructed for combined 
      photothermal therapy and chemotherapy of breast cancer. The pH-sensitive and 
      biocompatible biopolymer chitosan (CS) was grafted with N-vinylcaprolactam (NVCL) 
      and modified with biotin (Bio), imparting it with temperature sensitive property 
      and also the ability for active targeting. The polymer self-assembled to give 
      nanoparticles (NPs) loaded with indocyanine green (ICG) and doxorubicin (DOX). 
      When the NPs are exposed to near-infrared (NIR) laser irradiation, ICG converts 
      the light to heat, inducing a significant phase transition in the NPs and 
      facilitating the release of the drug cargo. In addition, the solubility of 
      chitosan is increased in the slightly acidic microenvironment of the tumor site, 
      which also promotes drug release. A detailed analysis of the NPs both in vitro 
      and in vivo showed that the carrier system is biocompatible, while the 
      drug-loaded NPs are selectively taken up by cancer cells. Particularly when 
      augmented with NIR irradiation, this leads to potent cell death in vitro and also 
      in an in vivo murine xenograft model of breast cancer.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Zhang, Yanyan
AU  - Zhang Y
AD  - College of Biological Science and Medical Engineering, Shanghai Engineering 
      Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua 
      University, Shanghai 201620, PR China.
FAU - Williams, Gareth R
AU  - Williams GR
AD  - UCL School of Pharmacy, University College London, 29-39 Brunswick Square, 
      London, WC1N 1AX, UK.
FAU - Lou, Jiadong
AU  - Lou J
AD  - College of Biological Science and Medical Engineering, Shanghai Engineering 
      Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua 
      University, Shanghai 201620, PR China.
FAU - Li, Wanting
AU  - Li W
AD  - Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and 
      Technology Achievement Incubation Center, Kunming Medical University, Kunming 
      650500, PR China.
FAU - Bai, Cuiwei
AU  - Bai C
AD  - Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and 
      Technology Achievement Incubation Center, Kunming Medical University, Kunming 
      650500, PR China.
FAU - Wang, Tong
AU  - Wang T
AD  - College of Biological Science and Medical Engineering, Shanghai Engineering 
      Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua 
      University, Shanghai 201620, PR China.
FAU - Niu, Shiwei
AU  - Niu S
AD  - Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and 
      Technology Achievement Incubation Center, Kunming Medical University, Kunming 
      650500, PR China.
FAU - Feng, Chun
AU  - Feng C
AD  - Department of Otolaryngology, the First People's Hospital of Yunnan Province, the 
      Affiliated Hospital of Kunming University of Science and Technology, Kunming 
      650032, PR China. Electronic address: dt0874@163.com.
FAU - Zhu, Li-Min
AU  - Zhu LM
AD  - College of Biological Science and Medical Engineering, Shanghai Engineering 
      Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua 
      University, Shanghai 201620, PR China. Electronic address: lzhu@dhu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221113
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 9012-76-4 (Chitosan)
RN  - 80168379AG (Doxorubicin)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Female
MH  - *Chitosan
MH  - Doxorubicin/pharmacology
MH  - *Nanoparticles
MH  - Indocyanine Green/pharmacology
MH  - *Breast Neoplasms/drug therapy
MH  - Drug Delivery Systems
MH  - Cell Line, Tumor
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Chitosan
OT  - Photothermal therapy
OT  - Thermosensitive material
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/16 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/11/15 19:23
PHST- 2022/09/08 00:00 [received]
PHST- 2022/10/30 00:00 [revised]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/11/16 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/11/15 19:23 [entrez]
AID - S0141-8130(22)02626-5 [pii]
AID - 10.1016/j.ijbiomac.2022.11.068 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Dec 31;223(Pt A):1356-1367. doi: 
      10.1016/j.ijbiomac.2022.11.068. Epub 2022 Nov 13.