PMID- 36380636
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240102
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 66
IP  - 1
DP  - 2023
TI  - High-Frequency Deep Sclerotomy as Adjunctive Therapy in Open-Angle Glaucoma 
      Patients.
PG  - 339-344
LID - 10.1159/000527677 [doi]
AB  - INTRODUCTION: Glaucoma is a chronic, progressive disease of the optic nerve that 
      can cause vision loss and blindness. High-frequency deep sclerotomy (HFDS) is a 
      novel ab interno procedure used to lower intraocular pressure (IOP). This study 
      aims at examining hypotensive effects of HFDS in patients with medically 
      uncontrolled primary open-angle glaucoma (POAG). METHODS: 23 patients (23 eyes) 
      participated in this study. They were all affected by POAG and used maximum 
      prescribed medical therapy. It is important to note that the target IOP was not 
      detected in any study participant. The target IOP is the highest IOP value at 
      which no new damages of the optic nerve occur. The procedure was performed with a 
      custom-made, high-frequency dissection probe by applying bipolar current of 500 
      kHz. Six pockets (1 mm deep, 0.3 mm high, and 6 mm wide) were made ab interno in 
      nasal sclera (through trabecular meshwork and Schlemm's canal). 
      Tobramycin/dexamethasone and pilocarpine eye drops were administered 
      postoperatively for a month. RESULTS: The mean value of the base IOP had been 
      25.6 mm Hg before the procedure. Significant complications were not recorded 
      either during the surgery or in a postoperative follow-up period. The average IOP 
      for our patients reduced by 8.6 mm Hg (33.6%) after a year. The mean value of the 
      instilled anti-glaucoma eye drops had been 2.78 (SD = 0.45) before the HFDS and 
      0.61 (SD = 1.04) at the end of the research. The target IOP was not achieved in 
      five cases (21.7% of our sample). DISCUSSION/CONCLUSION: This study presents the 
      data on our first surgical experience with HFDS that was conducted on 23 patients 
      who had medically uncontrolled POAG. The results indicate that HFDS is safe and 
      efficient in reducing IOP.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Kontic, Marko
AU  - Kontic M
AD  - Special Ophthalmology Hospital "Belgrade Ophthalmological Center", Belgrade, 
      Serbia.
FAU - Todorovic, Dusan
AU  - Todorovic D
AD  - Clinic of Ophthalmology, Clinical Center Kragujevac, Kragujevac, Serbia.
AD  - Department of Ophthalmology, Faculty of Medical Sciences, University of 
      Kragujevac, Kragujevac, Serbia.
FAU - Zecevic, Rada
AU  - Zecevic R
AD  - Special Ophthalmology Hospital "Belgrade Ophthalmological Center", Belgrade, 
      Serbia.
FAU - Vulovic, Tatjana Sarenac
AU  - Vulovic TS
AD  - Clinic of Ophthalmology, Clinical Center Kragujevac, Kragujevac, Serbia.
AD  - Department of Ophthalmology, Faculty of Medical Sciences, University of 
      Kragujevac, Kragujevac, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20221114
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0 (Ophthalmic Solutions)
SB  - IM
MH  - Humans
MH  - *Glaucoma, Open-Angle/surgery
MH  - Sclera/surgery
MH  - Trabecular Meshwork/surgery
MH  - Intraocular Pressure
MH  - *Trabeculectomy/methods
MH  - Ophthalmic Solutions
MH  - Treatment Outcome
OTO - NOTNLM
OT  - High-frequency deep sclerotomy
OT  - Intraocular pressure
OT  - Primary open-angle glaucoma
OT  - Treatment
EDAT- 2022/11/17 06:00
MHDA- 2023/12/25 06:42
CRDT- 2022/11/16 02:04
PHST- 2021/11/21 00:00 [received]
PHST- 2022/10/09 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2022/11/17 06:00 [pubmed]
PHST- 2022/11/16 02:04 [entrez]
AID - 000527677 [pii]
AID - 10.1159/000527677 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2023;66(1):339-344. doi: 10.1159/000527677. Epub 2022 Nov 14.