PMID- 36381817 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231103 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 14 IP - 10 DP - 2022 Oct TI - Laparoscopic-Assisted Endoscopic Retrograde Cholangiopancreatography (ERCP) Versus Endoscopic Ultrasound-Directed Transgastric ERCP in Patients With Roux-en-Y Gastric Bypass: A Systematic Review and Meta-Analysis. PG - e30196 LID - 10.7759/cureus.30196 [doi] LID - e30196 AB - Endoscopic retrograde cholangiopancreatography (ERCP) is a therapeutic procedure for skilled endoscopists that can be even more challenging in some situations, including patients' post-Roux-en-y Gastric Bypass (RYGB) surgery. There is still no consensus on whether laparoscopic-assisted ERCP (LA-ERCP) or endoscopic ultrasound (EUS)-directed transgastric ERCP (EDGE) is the most appropriate, safe, and feasible approach in patients with this type of post-surgical anatomy. This systematic review and meta-analysis aimed to examine both approaches' feasibility, efficacy, and safety in this situation. We searched for electronic databases (MEDLINE, EMBASE, Lilacs, Google Scholar, and Central Cochrane) to identify studies comparing LA-ERCP versus EDGE. Outcomes measured included technical success, adverse events (AEs) and serious AEs, length of stay (LOS), and procedural time. Descriptive data related to the EDGE procedure was also extracted. The risk of bias and the quality of evidence of the enrolled studies were assessed. Five studies, totalizing 268 patients (176 LA-ERCP and 92 EDGE), were included. There was no statistical difference in technical success and AEs between groups; however, the LOS and procedural times were shorter for the EDGE group. High rates of fistula closure and no weight regain were observed in EDGE. Both methods are feasible and safe techniques to perform ERCP in patients with RYGB anatomy, with comparable technical success and adverse events rate. However, EDGE is associated with shorter LOS and procedural time. CI - Copyright (c) 2022, de Oliveira et al. FAU - de Oliveira, Victor L AU - de Oliveira VL AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - de Moura, Diogo Turiani H AU - de Moura DTH AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - do Monte Junior, Epifanio S AU - do Monte Junior ES AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - Proenca, Igor M AU - Proenca IM AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - Ribeiro, Igor B AU - Ribeiro IB AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - Sanchez-Luna, Sergio A AU - Sanchez-Luna SA AD - Gastroenterology, University of Alabama at Birmingham Marnix E. Heersink School of Medicine, Birmingham, USA. FAU - Ribas, Pedro Henrique Boraschi V AU - Ribas PHBV AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - Hemerly, Matheus C AU - Hemerly MC AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - Bernardo, Wanderley M AU - Bernardo WM AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. FAU - de Moura, Eduardo Guimaraes H AU - de Moura EGH AD - Gastroenterology, Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, BRA. LA - eng PT - Journal Article PT - Review DEP - 20221011 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC9649332 OTO - NOTNLM OT - endoscopic retrograde cholangiopancreatography (ercp) OT - endoscopic ultrasound (eus) OT - endoscopy OT - laparoscopy OT - roux-en-y gastric bypass (rygb) OT - surgery COIS- The authors have declared financial relationships, which are detailed in the next section. EDAT- 2022/11/17 06:00 MHDA- 2022/11/17 06:01 PMCR- 2022/10/11 CRDT- 2022/11/16 02:57 PHST- 2022/10/11 00:00 [accepted] PHST- 2022/11/16 02:57 [entrez] PHST- 2022/11/17 06:00 [pubmed] PHST- 2022/11/17 06:01 [medline] PHST- 2022/10/11 00:00 [pmc-release] AID - 10.7759/cureus.30196 [doi] PST - epublish SO - Cureus. 2022 Oct 11;14(10):e30196. doi: 10.7759/cureus.30196. eCollection 2022 Oct.