PMID- 36382089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221117
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 24
IP  - 6
DP  - 2022 Dec
TI  - Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent 
      spontaneous abortion.
PG  - 729
LID - 10.3892/etm.2022.11665 [doi]
LID - 729
AB  - Human leukocyte antigen (HLA)-G is an important molecule that maintains 
      maternal-fetal interface tolerance and plays a vital role in a healthy pregnancy. 
      Single-nucleotide polymorphisms in the 3'-untranslated regions (UTR) of the HLA-G 
      gene may differ in women with unexplained recurrent spontaneous abortion (URSA). 
      The present study involved the isolation of genome DNA from peripheral blood 
      leukocytes, Sanger sequencing and analysis of the polymorphism sites in the 3'UTR 
      of the HLA-G gene based on polymerase chain reaction. In total, 261 DNA samples 
      from cases of URSA (n=133), including primary URSA (n=83) and secondary URSA 
      (n=50), and controls (n=128) were evaluated. The present data showed that +3010CC 
      genotype carriers exhibited a higher risk of URSA, while +3187GG genotype 
      carriers exhibited a lower risk. Secondary URSA patients carrying +3010C had a 
      higher risk of URSA, while +3187G carriers exhibited a lower risk of URSA. UTR-1 
      haplotype carriers may be associated with a reduced risk of primary and secondary 
      URSA. Notably, UTR-3 and UTR-7 could increase the risk of primary and secondary 
      URSA, respectively. The present results showed that HLA-G 3'UTR polymorphisms and 
      haplotypes may be involved in URSA development and be a predictor of pregnancy 
      outcome.
CI  - Copyright: (c) Bai et al.
FAU - Bai, Wei
AU  - Bai W
AD  - Department of Clinical Laboratory, Wenzhou Hospital of Traditional Chinese 
      Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Lin, Zhi
AU  - Lin Z
AD  - Department of Clinical Laboratory, Wenzhou Hospital of Traditional Chinese 
      Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Ye, Jin
AU  - Ye J
AD  - Department of Clinical Laboratory, Wenzhou Hospital of Traditional Chinese 
      Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Zhou, Linshuang
AU  - Zhou L
AD  - Department of Clinical Laboratory, Wenzhou Hospital of Traditional Chinese 
      Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Xi, Jingqiao
AU  - Xi J
AD  - Department of Clinical Laboratory, Wenzhou Hospital of Traditional Chinese 
      Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Cai, Wenpin
AU  - Cai W
AD  - Department of Clinical Laboratory, Wenzhou Hospital of Traditional Chinese 
      Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang 
      325000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20221024
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC9634346
OTO - NOTNLM
OT  - 3'-untranslated region
OT  - haplotype
OT  - human leukocyte antigen
OT  - polymorphism
OT  - unexplained recurrent spontaneous abortion
COIS- The authors declare that they have no competing interests.
EDAT- 2022/11/17 06:00
MHDA- 2022/11/17 06:01
PMCR- 2022/10/24
CRDT- 2022/11/16 03:00
PHST- 2022/05/10 00:00 [received]
PHST- 2022/09/08 00:00 [accepted]
PHST- 2022/11/16 03:00 [entrez]
PHST- 2022/11/17 06:00 [pubmed]
PHST- 2022/11/17 06:01 [medline]
PHST- 2022/10/24 00:00 [pmc-release]
AID - ETM-24-6-11665 [pii]
AID - 10.3892/etm.2022.11665 [doi]
PST - epublish
SO  - Exp Ther Med. 2022 Oct 24;24(6):729. doi: 10.3892/etm.2022.11665. eCollection 
      2022 Dec.