PMID- 36382640
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 66
IP  - 1
DP  - 2023
TI  - Early Retinal Microvasculopathy in Prediabetic Patients and Correlated Factors.
PG  - 367-376
LID - 10.1159/000527957 [doi]
AB  - INTRODUCTION: We aimed to detect early retinal microcirculation changes in 
      prediabetic patients and investigate their correlation with clinical 
      examinations. METHODS: Forty-seven prediabetic individuals, 29 controls, and 81 
      type 2 diabetic mellitus (T2DM) patients were enrolled in this study. A review of 
      clinical data and spectral-domain optical coherence tomography angiography 
      (SD-OCTA) parameters of macular vessel diameter (VD), foveal avascular zone 
      (FAZ), and macular vessel area density (VAD) was performed. RESULTS: Levels of 
      low-density lipoprotein cholesterol and triglycerides in prediabetes and T2DM 
      groups were significantly higher than those in the control group. The urine 
      microalbumin-to-creatinine ratio (ACR) was mildly and moderately increased in the 
      prediabetes and T2DM groups, respectively. The estimated glomerular filtration 
      rate of the three groups was within the normal range. SD-OCTA showed that VAD in 
      the superficial macular area was decreased in the prediabetes group compared to 
      the control group (p = 0.01). The FAZ size, particularly in the deep layer, was 
      expanded in the prediabetes group. In the deep retinal layer of the macular area, 
      VD and FAZ size in the prediabetes group were larger than those in the control 
      group. In the prediabetes group, the axial length was significantly correlated 
      with macular VD and FAZ size (p < 0.05), and ACR was correlated with FAZ size (p 
      < 0.05). Age had a negative correlation with VAD (p < 0.01). ACR had a positive 
      correlation with FAZ size (p < 0.05). CONCLUSIONS: Enlargement and irregularity 
      of the FAZ area, deep capillary dilation, and a decrease in VAD occur in the 
      retina of prediabetic patients with mild kidney function impairment.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Xu, Yi
AU  - Xu Y
AD  - Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and 
      Treatment Center/Shanghai Eye Hospital, Shanghai, China.
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye 
      Diseases, Shanghai, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.
FAU - Zhu, Xiaofeng
AU  - Zhu X
AD  - Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and 
      Treatment Center/Shanghai Eye Hospital, Shanghai, China, carrie915@126.com.
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China, carrie915@126.com.
AD  - Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye 
      Diseases, Shanghai, China, carrie915@126.com.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China, 
      carrie915@126.com.
AD  - Shanghai Key Laboratory of Fundus Diseases, Shanghai, China, carrie915@126.com.
FAU - Wang, Yongyi
AU  - Wang Y
AD  - Department of Medical Administration, Huizhou First Hospital, Huizhou, China.
FAU - Chu, Zhongdi
AU  - Chu Z
AD  - Departments of Bioengineering and Ophthalmology, University of Washington, 
      Seattle, Washington, USA.
FAU - Wang, Ruikang K
AU  - Wang RK
AD  - Departments of Bioengineering and Ophthalmology, University of Washington, 
      Seattle, Washington, USA.
FAU - Lu, Lina
AU  - Lu L
AD  - Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and 
      Treatment Center/Shanghai Eye Hospital, Shanghai, China.
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye 
      Diseases, Shanghai, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.
FAU - Zou, Haidong
AU  - Zou H
AD  - Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and 
      Treatment Center/Shanghai Eye Hospital, Shanghai, China.
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye 
      Diseases, Shanghai, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221116
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Humans
MH  - *Prediabetic State/complications/diagnosis
MH  - Fluorescein Angiography/methods
MH  - Retinal Vessels
MH  - Retrospective Studies
MH  - Retina
MH  - Tomography, Optical Coherence/methods
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
OTO - NOTNLM
OT  - Estimated glomerular filtration rate
OT  - Optical coherence tomography angiography
OT  - Prediabetes
OT  - Urine microalbumin-creatinine ratio
EDAT- 2022/11/17 06:00
MHDA- 2023/12/25 06:42
CRDT- 2022/11/16 05:53
PHST- 2022/06/18 00:00 [received]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2022/11/17 06:00 [pubmed]
PHST- 2022/11/16 05:53 [entrez]
AID - 000527957 [pii]
AID - 10.1159/000527957 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2023;66(1):367-376. doi: 10.1159/000527957. Epub 2022 Nov 16.