PMID- 36382644
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230218
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 184
IP  - 2
DP  - 2023
TI  - The Association of HLA Alleles and Haplotypes with Age of Disease Onset in 
      Pakistani Psoriatic Patients.
PG  - 202-210
LID - 10.1159/000527359 [doi]
AB  - INTRODUCTION: The human leukocyte antigen (HLA) region on chromosome 6p21 is well 
      known to carry the most important genetic factors in susceptibility to psoriasis. 
      Different HLA alleles and haplotypes have been reported to be associated with 
      psoriasis in different populations. Psoriasis has a variable age of onset and, 
      based on this, it can be classified into two types; type I with age of onset 
      before 40 years of age and type II with age of onset after 40 years of age. The 
      objective of this study was to determine the association of HLA class I and class 
      II alleles and haplotypes with disease and stratification using age of onset in 
      Pakistani psoriatic patients. METHODS: A group of 603 individuals (326 cases and 
      277 controls) were analyzed for HLA class I and II alleles and haplotype 
      association by sequence specific PCR. The association was further analyzed 
      according to the age of onset of the patients. RESULTS: We found that HLA alleles 
      B*57 and Cw*06:02, DQB1*03:03:02 are strongly associated with early onset 
      psoriasis, while alleles B*15, DRB1*13:02 and DQB1*03:03:02 are associated with 
      late-onset psoriasis. Cw*06:02 allele was not associated with late-onset 
      psoriasis patients. Allele DQB1*03:03:02 had the highest odds ratio in all 
      patients. We found a novel association specifically with late-onset psoriasis 
      samples with the haplotype HLA-A*11; B*15; Cw*04; DRB1*15; DQB1*05 (Pc = 3.60 x 
      10-7). We also found strong association with previously reported extended 
      haplotype EH-57.1: HLA-B*57; Cw*06:02; DRB1*07:01; DQB1*03:03:02 in all our 
      patients (Pc = 8.34 x 10-07). CONCLUSION: Our results show that different HLA 
      class I and II alleles and haplotypes are associated with psoriasis at different 
      age of onset. In this study, we have reported novel alleles and haplotype 
      association with late-onset psoriasis. Our data confirm the previous strong 
      associations with HLA alleles and haplotypes and also reports novel alleles and 
      haplotype association in Pakistani psoriasis patients.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Munir, Saeeda
AU  - Munir S
AD  - Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan, 
      saeedaonline@yahoo.com.
FAU - Rahman, Simeen Ber
AU  - Rahman SB
AD  - Skin and Laser Clinic, Rawalpindi, Pakistan.
FAU - Rehman, Sadia
AU  - Rehman S
AD  - Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
FAU - Saba, Nusrat
AU  - Saba N
AD  - Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
FAU - Mazhar, Kehkashan
AU  - Mazhar K
AD  - Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
FAU - Naluai, Asa Torinsson
AU  - Naluai AT
AD  - Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, 
      Gothenburg, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20221116
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Haplotypes
MH  - Pakistan
MH  - *Histocompatibility Antigens Class II/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - *Psoriasis/epidemiology/genetics
MH  - Alleles
MH  - HLA-DRB1 Chains/genetics
MH  - Genetic Predisposition to Disease
MH  - Gene Frequency
PMC - PMC9932843
OTO - NOTNLM
OT  - Autoimmunity
OT  - HLA allele
OT  - Haplotype
OT  - Psoriasis
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/11/17 06:00
MHDA- 2023/02/08 06:00
PMCR- 2022/11/16
CRDT- 2022/11/16 05:53
PHST- 2022/01/09 00:00 [received]
PHST- 2022/09/01 00:00 [accepted]
PHST- 2022/11/17 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2022/11/16 05:53 [entrez]
PHST- 2022/11/16 00:00 [pmc-release]
AID - 000527359 [pii]
AID - iaa-0184-0202 [pii]
AID - 10.1159/000527359 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2023;184(2):202-210. doi: 10.1159/000527359. Epub 2022 
      Nov 16.