PMID- 36383673
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240512
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 8
IP  - 46
DP  - 2022 Nov 18
TI  - Chaperone-mediated autophagy regulates adipocyte differentiation.
PG  - eabq2733
LID - 10.1126/sciadv.abq2733 [doi]
LID - eabq2733
AB  - Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes 
      differentiate into adipocytes. The most studied aspect of adipogenesis is its 
      transcriptional regulation through timely expression and silencing of a vast 
      number of genes. However, whether turnover of key regulatory proteins per se 
      controls adipogenesis remains largely understudied. Chaperone-mediated autophagy 
      (CMA) is a selective form of lysosomal protein degradation that, in response to 
      diverse cues, remodels the proteome for regulatory purposes. We report here the 
      activation of CMA during adipocyte differentiation and show that CMA regulates 
      adipogenesis at different steps through timely degradation of key regulatory 
      signaling proteins and transcription factors that dictate proliferation, 
      energetic adaptation, and signaling changes required for adipogenesis.
FAU - Kaushik, Susmita
AU  - Kaushik S
AUID- ORCID: 0000-0002-6096-5387
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Juste, Yves R
AU  - Juste YR
AUID- ORCID: 0000-0002-7237-2327
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Lindenau, Kristen
AU  - Lindenau K
AUID- ORCID: 0000-0001-6145-5322
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Dong, Shuxian
AU  - Dong S
AUID- ORCID: 0000-0003-4725-8482
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Macho-Gonzalez, Adrian
AU  - Macho-Gonzalez A
AUID- ORCID: 0000-0001-7644-1759
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Santiago-Fernandez, Olaya
AU  - Santiago-Fernandez O
AUID- ORCID: 0000-0002-5933-3104
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - McCabe, Mericka
AU  - McCabe M
AUID- ORCID: 0000-0001-6758-2330
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
AD  - Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Singh, Rajat
AU  - Singh R
AUID- ORCID: 0000-0001-9389-8574
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Gavathiotis, Evripidis
AU  - Gavathiotis E
AUID- ORCID: 0000-0001-6319-8331
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
AD  - Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Cuervo, Ana Maria
AU  - Cuervo AM
AUID- ORCID: 0000-0002-0771-700X
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
LA  - eng
GR  - R01 AG021904/AG/NIA NIH HHS/United States
GR  - T32 AG023475/AG/NIA NIH HHS/United States
GR  - R37 AG021904/AG/NIA NIH HHS/United States
GR  - T32 GM007491/GM/NIGMS NIH HHS/United States
GR  - P30 DK020541/DK/NIDDK NIH HHS/United States
GR  - RF1 AG054108/AG/NIA NIH HHS/United States
GR  - P30 AG038072/AG/NIA NIH HHS/United States
GR  - P60 DK020541/DK/NIDDK NIH HHS/United States
GR  - R01 DK098408/DK/NIDDK NIH HHS/United States
GR  - P30 CA013330/CA/NCI NIH HHS/United States
GR  - P01 AG031782/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20221116
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
SB  - IM
PMC - PMC9668314
EDAT- 2022/11/17 06:00
MHDA- 2022/11/17 06:01
PMCR- 2022/11/16
CRDT- 2022/11/16 14:05
PHST- 2022/11/16 14:05 [entrez]
PHST- 2022/11/17 06:00 [pubmed]
PHST- 2022/11/17 06:01 [medline]
PHST- 2022/11/16 00:00 [pmc-release]
AID - abq2733 [pii]
AID - 10.1126/sciadv.abq2733 [doi]
PST - ppublish
SO  - Sci Adv. 2022 Nov 18;8(46):eabq2733. doi: 10.1126/sciadv.abq2733. Epub 2022 Nov 
      16.