PMID- 36385002 OWN - NLM STAT- MEDLINE DCOM- 20231221 LR - 20240306 IS - 1468-2079 (Electronic) IS - 0007-1161 (Linking) VI - 108 IP - 1 DP - 2023 Dec 18 TI - Rates of choroidal loss and ganglion cell-inner plexiform layer thinning in type 2 diabetes mellitus and healthy individuals: a 2-year prospective study. PG - 84-90 LID - 10.1136/bjo-2022-321603 [doi] AB - AIMS: To investigate longitudinal choroid and ganglion cell-inner plexiform layer (GCIPL) changes in type 2 diabetes mellitus (T2DM) patients and healthy populations across 2 years. METHODS: This prospective cohort study included T2DM patients and healthy controls. T2DM patients were divided into mild non-proliferative diabetic retinopathy (NPDR) or non-DR (NDR) groups. Macular choroidal and GCIPL thickness was measured using swept-source optical coherence tomography at baseline and follow-up after 2 years. A linear-mixed effect model compared rates of change in choroidal and GCIPL thicknesses between the three groups. RESULTS: 895 T2DM patients (770 in the NDR group and 125 in the NPDR group) and 847 healthy controls were included. Following 2 years, choroidal thinning occurred at a rate of -7.7+/-9.2 microm/year, -8.1+/-8.7 microm/year and -5.2+/-8.1 microm/year in NDR, NPDR and control groups, respectively (p<0.001). GCIPL loss occurred quickest in NPDR patients (-0.97+/-0.97 microm/year), followed by NDR (-0.91+/-0.89 microm/year) and the control group (-0.04+/-0.55 microm/year) (p<0.001). Following multivariate adjustment, choroidal thinning was -2.04 microm/year (95% CI: -4.05 to -0.03; p=0.047) and -1.95 microm/year (95% CI: -3.14 to -0.75; p=0.001) faster in NPDR and NDR groups than in the control group, respectively, and GCIPL thinning was -1.02 microm/year (95% CI: -1.19 to -0.84; p<0.001) and -0.88 microm/year (95% CI: -0.98 to -0.78; p<0.001) faster in the NPDR and NDR groups than in the control group, respectively. CONCLUSION: Progressive choroidal and GCIPL thinning occurs in healthy individuals and T2DM patients; however, T2DM undergoes accelerated choroidal and GCIPL loss in NPDR patients. CI - (c) Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Hui, Ziwen AU - Hui Z AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. AD - Zhongs School of Medicine, Sun Yat-Sen University, Guangzhou, China. FAU - Guo, Xiao AU - Guo X AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. FAU - Bulloch, Gabriella AU - Bulloch G AD - Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia. FAU - Yuan, Meng AU - Yuan M AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. FAU - Xiong, Kun AU - Xiong K AUID- ORCID: 0000-0002-3918-9782 AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. FAU - Zhang, Shiran AU - Zhang S AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. FAU - Chen, Yifan AU - Chen Y AD - University of Oxford, Oxford, UK. FAU - Li, Yuting AU - Li Y AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. FAU - Liao, Huan AU - Liao H AD - University of Melbourne, Melbourne, Victoria, Australia. FAU - Huang, Wenyong AU - Huang W AUID- ORCID: 0000-0003-3167-0851 AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. FAU - Zhu, Zhuoting AU - Zhu Z AD - Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia wangwei@gzzoc.com lisa.zhu@unimelb.edu.au. FAU - Wang, Wei AU - Wang W AUID- ORCID: 0000-0002-5273-3332 AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China wangwei@gzzoc.com lisa.zhu@unimelb.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231218 PL - England TA - Br J Ophthalmol JT - The British journal of ophthalmology JID - 0421041 SB - IM MH - Humans MH - Prospective Studies MH - *Diabetes Mellitus, Type 2/complications MH - Retina MH - *Diabetic Retinopathy/diagnosis MH - Choroid MH - Tomography, Optical Coherence/methods OTO - NOTNLM OT - Choroid OT - Epidemiology OT - Retina COIS- Competing interests: None declared. EDAT- 2022/11/18 06:00 MHDA- 2023/12/21 06:42 CRDT- 2022/11/17 10:13 PHST- 2022/04/04 00:00 [received] PHST- 2022/10/26 00:00 [accepted] PHST- 2023/12/21 06:42 [medline] PHST- 2022/11/18 06:00 [pubmed] PHST- 2022/11/17 10:13 [entrez] AID - bjo-2022-321603 [pii] AID - 10.1136/bjo-2022-321603 [doi] PST - epublish SO - Br J Ophthalmol. 2023 Dec 18;108(1):84-90. doi: 10.1136/bjo-2022-321603.