PMID- 36385250
OWN - NLM
STAT- MEDLINE
DCOM- 20230202
LR  - 20230202
IS  - 1865-7265 (Electronic)
IS  - 1865-7265 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Feb
TI  - Eosinophilic pancreatitis with serum IgG4-positivity, potentially associated with 
      autoimmune pancreatitis.
PG  - 96-104
LID - 10.1007/s12328-022-01732-3 [doi]
AB  - A 70-year-old man presented with unprovoked weight loss and intermittent left 
      upper quadrant tenderness for one-and-a-half month. Computed tomography revealed 
      irregular cystic lesions in the pancreatic tail. Endoscopic ultrasonography (EUS) 
      revealed pancreatic tail enlargement and giant, thick-walled cysts surrounding 
      the pancreatic tail with no connection with the pancreatic duct. Endoscopic 
      ultrasonography-guided fine-needle aspiration was performed on the enlarged 
      pancreatic parenchyma and thickened cyst wall. Both biopsies showed hyper 
      eosinophilia and few plasma cells. Endoscopic retrograde pancreatography revealed 
      an irregular narrowing of the main pancreatic duct. Pancreatic juice cytology 
      revealed substantial eosinophilia. Blood sampling showed an elevated eosinophil 
      count and immunoglobulin G4 (IgG4) and immunoglobulin E (IgE) levels at the 
      initial examination. We considered the patient to have eosinophilic pancreatitis 
      (EP) with autoimmune pancreatitis, or alternately, EP with IgG4-related 
      retroperitoneal fibrosis (RPF). Upon prednisolone administration, the abdominal 
      pain improved, the peripheral blood eosinophil count decreased to zero, IgG4 and 
      IgE levels decreased, pancreatic enlargement improved, and the cystic lesions 
      disappeared. The condition did not recur within the following 3 years. Both EP 
      and EP with IgG4-related RPF are rare etiologies of pancreatitis, and this case 
      is very instructive.
CI  - (c) 2022. Japanese Society of Gastroenterology.
FAU - Takeda, Shodai
AU  - Takeda S
AD  - Department of Gastroenterology, Shizuoka General Hospital, 4-27-1, Kita-Ando, 
      Aoiku, Shizuoka, 420-8527, Japan.
FAU - Satoh, Tatsunori
AU  - Satoh T
AUID- ORCID: 0000-0002-1756-3147
AD  - Department of Gastroenterology, Shizuoka General Hospital, 4-27-1, Kita-Ando, 
      Aoiku, Shizuoka, 420-8527, Japan. tatsunori-sato@i.shizuoka-pho.jp.
FAU - Kawaguchi, Shinya
AU  - Kawaguchi S
AD  - Department of Gastroenterology, Shizuoka General Hospital, 4-27-1, Kita-Ando, 
      Aoiku, Shizuoka, 420-8527, Japan.
FAU - Endo, Shinya
AU  - Endo S
AD  - Department of Gastroenterology, Shizuoka General Hospital, 4-27-1, Kita-Ando, 
      Aoiku, Shizuoka, 420-8527, Japan.
FAU - Terada, Shuzo
AU  - Terada S
AD  - Department of Gastroenterology, Shizuoka General Hospital, 4-27-1, Kita-Ando, 
      Aoiku, Shizuoka, 420-8527, Japan.
FAU - Muramatsu, Aya
AU  - Muramatsu A
AD  - Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20221116
PL  - Japan
TA  - Clin J Gastroenterol
JT  - Clinical journal of gastroenterology
JID - 101477246
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - *Autoimmune Pancreatitis
MH  - *Autoimmune Diseases/complications/diagnosis
MH  - Neoplasm Recurrence, Local
MH  - *Pancreatitis/complications/diagnosis
MH  - Immunoglobulin G
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Autoimmune pancreatitis
OT  - Eosinophilic infiltration
OT  - Eosinophilic pancreatitis
OT  - Pancreatic cyst
EDAT- 2022/11/18 06:00
MHDA- 2023/02/03 06:00
CRDT- 2022/11/17 10:44
PHST- 2022/02/19 00:00 [received]
PHST- 2022/10/30 00:00 [accepted]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2023/02/03 06:00 [medline]
PHST- 2022/11/17 10:44 [entrez]
AID - 10.1007/s12328-022-01732-3 [pii]
AID - 10.1007/s12328-022-01732-3 [doi]
PST - ppublish
SO  - Clin J Gastroenterol. 2023 Feb;16(1):96-104. doi: 10.1007/s12328-022-01732-3. 
      Epub 2022 Nov 16.