PMID- 36386943
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221118
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Effect of natural polyphenols in Chinese herbal medicine on obesity and diabetes: 
      Interactions among gut microbiota, metabolism, and immunity.
PG  - 962720
LID - 10.3389/fnut.2022.962720 [doi]
LID - 962720
AB  - With global prevalence, metabolic diseases, represented by obesity and type 2 
      diabetes mellitus (T2DM), have a huge burden on human health and medical 
      expenses. It is estimated that obese population has doubled in recent 40 years, 
      and population with diabetes will increase 1.5 times in next 25 years, which has 
      inspired the pursuit of economical and effective prevention and treatment 
      methods. Natural polyphenols are emerging as a class of natural bioactive 
      compounds with potential beneficial effects on the alleviation of obesity and 
      T2DM. In this review, we investigated the network interaction mechanism of "gut 
      microbial disturbance, metabolic disorder, and immune imbalance" in both obesity 
      and T2DM and systemically summarized their multiple targets in the treatment of 
      obesity and T2DM, including enrichment of the beneficial gut microbiota (genera 
      Bifidobacterium, Akkermansia, and Lactobacillus) and upregulation of the levels 
      of gut microbiota-derived metabolites [short-chain fatty acids (SCFAs)] and bile 
      acids (BAs). Moreover, we explored their effect on host glucolipid metabolism, 
      the AMPK pathway, and immune modulation via the inhibition of pro-inflammatory 
      immune cells (M1-like Mvarphis, Th1, and Th17 cells); proliferation, recruitment, 
      differentiation, and function; and related cytokines (TNF-alpha, IL-1beta, IL-6, IL-17, 
      and MCP-1). We hope to provide evidence to promote the clinical application of 
      natural polyphenols in the management of obesity and T2DM.
CI  - Copyright (c) 2022 Chen, Gao, Ding, Tang, Zhang, Zhai, Xie, Jin, Zhao and Liu.
FAU - Chen, Keyu
AU  - Chen K
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Graduate School, Beijing University of Chinese Medicine, Beijing, China.
FAU - Gao, Zezheng
AU  - Gao Z
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Ding, Qiyou
AU  - Ding Q
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Graduate School, Beijing University of Chinese Medicine, Beijing, China.
FAU - Tang, Cheng
AU  - Tang C
AD  - College of Traditional Chinese Medicine, Changchun University of Chinese 
      Medicine, Changchun, China.
FAU - Zhang, Haiyu
AU  - Zhang H
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Zhai, Tiangang
AU  - Zhai T
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Graduate School, Beijing University of Chinese Medicine, Beijing, China.
FAU - Xie, Weinan
AU  - Xie W
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Graduate School, Beijing University of Chinese Medicine, Beijing, China.
FAU - Jin, Zishan
AU  - Jin Z
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Graduate School, Beijing University of Chinese Medicine, Beijing, China.
FAU - Zhao, Linhua
AU  - Zhao L
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Liu, Wenke
AU  - Liu W
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221028
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9651142
OTO - NOTNLM
OT  - gut microbiota
OT  - inflammation
OT  - natural polyphenols
OT  - obesity
OT  - traditional Chinese medicine
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/18 06:01
PMCR- 2022/01/01
CRDT- 2022/11/17 11:51
PHST- 2022/06/06 00:00 [received]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/11/17 11:51 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/18 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.962720 [doi]
PST - epublish
SO  - Front Nutr. 2022 Oct 28;9:962720. doi: 10.3389/fnut.2022.962720. eCollection 
      2022.