PMID- 36387648
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221118
IS  - 2249-4863 (Print)
IS  - 2278-7135 (Electronic)
IS  - 2249-4863 (Linking)
VI  - 11
IP  - 7
DP  - 2022 Jul
TI  - A retrospective study to find out the correlation between NAFLD, diabetes, and 
      obesity in Indian patients.
PG  - 3504-3510
LID - 10.4103/jfmpc.jfmpc_2212_21 [doi]
AB  - BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is present in the body with 
      metabolic disorders such as Type 2 diabetes mellitus (T2DM), obesity, and 
      cardiovascular disease. However, no significant evidence has been found till date 
      exhibiting their association epidemiologically in Indian patients. OBJECTIVE: To 
      assess the association among NAFLD, T2DM, and obesity, and to validate the 
      scoring system with grades of fatty liver (severity of liver disease) estimated 
      by ultrasound vs. NAFLD fibrosis score, BARD score, and aspartate 
      aminotransferase to platelet ratio index (APRI) score. METHODOLOGY: A 
      retrospective, observational study was conducted out in patients with NAFLD (n = 
      316) where diagnosis and grades of fatty liver were established via ultrasound 
      reports. The patients were divided into two groups, Group A (n = 114, NAFLD with 
      T2DM) and Group B (n = 202, NAFLD without T2DM). R 4.0.0 was used for statistical 
      analysis. RESULTS: The mean age (in years) of the patients was 54.08 +/- 10.78 in 
      Group A and 48.10 +/- 15.36 in Group B. The mean BMI in Group A was found to be 
      slightly higher as compared to Group B, 27.49 +/- 4.94 and 26.56 +/- 4.68, 
      respectively, and the difference was found to be statistically significant 
      (p-value <0.05). The overall predictive ability of the NAFLD scoring system 
      matched that to ultrasonography liver grading fibrosis report for approximately 
      53% of patients. The BARD scoring system was found to be matched with 
      ultrasonography reported Grade 1 fatty liver (198/316). In the case of the APRI 
      scoring system, the association was not observed with ultrasonography reports in 
      any grades of fatty liver. CONCLUSION: Body mass index might be an independent 
      risk factor for NAFLD. NAFLD fibrosis score appears to be a reliable non-invasive 
      tool to determine the severity of liver fibrosis in NAFLD patients. BARD score 
      may predict Grade 1 liver fibrosis. However, APRI scores do not correlate with 
      imaging evidence of fibrosis like NAFLD and BARD scores.
CI  - Copyright: (c) 2022 Journal of Family Medicine and Primary Care.
FAU - Saran, Mohit
AU  - Saran M
AD  - Department of Medicine, Bhagwan Mahavir Hospital, Rohini, New Delhi, India.
FAU - Sharma, Jugal Kishore
AU  - Sharma JK
AD  - Department of Endocrinology, Central Delhi Diabetes Centre, New Delhi, India.
FAU - Ranjan, Aastha
AU  - Ranjan A
AD  - Real-World Evidence, THB: Technology | Healthcare | Big Data Analytics, Gurgaon, 
      Haryana, India.
FAU - Deka, Saurav
AU  - Deka S
AD  - Real-World Evidence, THB: Technology | Healthcare | Big Data Analytics, Gurgaon, 
      Haryana, India.
FAU - Sabharwal, Mudit
AU  - Sabharwal M
AD  - Department of Endocrinology, Dharma Diabetes and Metabolic Clinic, Gurgaon, 
      Haryana, India.
FAU - Palukari, Srivani
AU  - Palukari S
AD  - Real-World Evidence, THB: Technology | Healthcare | Big Data Analytics, Gurgaon, 
      Haryana, India.
FAU - Chandolia, Betina
AU  - Chandolia B
AD  - Real-World Evidence, THB: Technology | Healthcare | Big Data Analytics, Gurgaon, 
      Haryana, India.
LA  - eng
PT  - Journal Article
DEP - 20220722
PL  - India
TA  - J Family Med Prim Care
JT  - Journal of family medicine and primary care
JID - 101610082
PMC - PMC9648271
OTO - NOTNLM
OT  - NAFLD score
OT  - non-alcoholic fatty liver disease
OT  - obesity
OT  - type 2 diabetes
COIS- There are no conflicts of interest.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/18 06:01
PMCR- 2022/07/01
CRDT- 2022/11/17 12:01
PHST- 2021/11/10 00:00 [received]
PHST- 2022/02/11 00:00 [revised]
PHST- 2022/02/15 00:00 [accepted]
PHST- 2022/11/17 12:01 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/18 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - JFMPC-11-3504 [pii]
AID - 10.4103/jfmpc.jfmpc_2212_21 [doi]
PST - ppublish
SO  - J Family Med Prim Care. 2022 Jul;11(7):3504-3510. doi: 
      10.4103/jfmpc.jfmpc_2212_21. Epub 2022 Jul 22.