PMID- 36387843
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20221222
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Perirenalfat thickness is associated with bone turnover markers and bone mineral 
      density in postmenopausal women with type 2 diabetes mellitus.
PG  - 990667
LID - 10.3389/fendo.2022.990667 [doi]
LID - 990667
AB  - OBJECTIVES: Emerging evidence demonstrated that perirenal fat may modulate bone 
      metabolism through several pathological pathways. This study was aimed to assess 
      the associations between perirenal fat thickness (PrFT) and bone turnover markers 
      (BTMs) and bone mineral density (BMD) in postmenopausal women with type 2 
      diabetes mellitus (T2DM) and further explore the correlation between PrFT and 
      osteoporosis. METHODS: In this cross-sectional study, a total of 626 participants 
      with complete data were enrolled in this study. Demographic and anthropometric 
      information was collected. Biochemical parameters and BTMs were determined. PrFT 
      and BMD were measured by computed tomography and dual-energy x-ray 
      absorptiometry, respectively. Correlation analysis and regression models were 
      used to assess the associations between PrFT and BTMs and BMD. The multiple 
      binomial logistic regression model was used to estimate the independent variables 
      of PrFT for osteoporosis. RESULTS: Overall, the prevalence of osteoporosis was 
      38.7%. PrFT was negatively correlated with beta-cross-linked C-telopeptide of type I 
      collagen (beta-CTX) (r = -0.216,< 0.001), L1-L4 BMD (r = -0.351, < 0.001), and 
      T-score (r = -0.396, < 0.001). PrFT also remained significantly correlated with 
      beta-CTX (beta = -0.291, P< 0.001), L1-L4 BMD (beta = -0.109, P= 0.027), and L1-L4 T-score 
      (beta = -0.149, P= 0.001) after adjustment for other confounding factors. 
      Furthermore, PrFT was also independently associated with osteoporosis after 
      adjustment for other confounding factors; the OR (95% CI) was 1.13 (1.04-1.23). 
      PrFT also seems to have a relatively good identifying value for osteoporosis. The 
      area under the curve (AUC) value of PrFT in identifying osteoporosis was 0.766 
      (95% CI: 0.705-0.826, P < 0.001). The optimal cutoff value of PrFT was 15.2 mm 
      (sensitivity: 72.5%, specificity: 79.8%). CONCLUSIONS: PrFT was significantly 
      associated with beta-CTX, BMD, and osteoporosis. These findings indicate that 
      perirenal fat may play an important role in bone metabolism. CLINICAL TRIAL 
      REGISTRATION: http://www.chictr.org.cn/, identifier (ChiCTR2100052032).
CI  - Copyright (c) 2022 Wang, Huang, Tang, Tu and Guo.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical 
      University, Longyan, China.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical 
      University, Longyan, China.
FAU - Tang, Ping Tai
AU  - Tang PT
AD  - Department of Radiology, Longyan First Affiliated Hospital of Fujian Medical 
      University, Longyan, China.
FAU - Tu, Mei
AU  - Tu M
AD  - Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical 
      University, Longyan, China.
FAU - Guo, Xiu Li
AU  - Guo XL
AD  - Department of Radiology, Longyan First Affiliated Hospital of Fujian Medical 
      University, Longyan, China.
LA  - eng
SI  - ChiCTR/ChiCTR2100052032
PT  - Journal Article
DEP - 20221025
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Biomarkers)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Female
MH  - Humans
MH  - Bone Density
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Postmenopause
MH  - Cross-Sectional Studies
MH  - Biomarkers
MH  - *Osteoporosis
MH  - Collagen
MH  - Bone Remodeling
PMC - PMC9641290
OTO - NOTNLM
OT  - bone mineral density
OT  - bone turnover markers
OT  - perirenal fat thickness
OT  - postmenopausal women
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/22 06:00
PMCR- 2022/01/01
CRDT- 2022/11/17 12:04
PHST- 2022/07/10 00:00 [received]
PHST- 2022/10/06 00:00 [accepted]
PHST- 2022/11/17 12:04 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.990667 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Oct 25;13:990667. doi: 
      10.3389/fendo.2022.990667. eCollection 2022.