PMID- 36388171
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20221121
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2022
DP  - 2022
TI  - Exosomes Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell 
      Proliferation through the Wnt3a/beta-Catenin Signaling Pathway.
PG  - 9042345
LID - 10.1155/2022/9042345 [doi]
LID - 9042345
AB  - Both hair follicle stem cells (HFSC) and dermal papilla cells (DPC) are essential 
      for hair follicle growth and proliferation. In this study, HFSCs and DPCs that 
      made signature proteins like KRT14, KRT15, KRT19, alpha-SMA, and Versican were 
      obtained. Cell coculture systems between HFSCs and DPCs were used to measure the 
      increased PCNA protein content in HFSCs. Additionally, exosomes from dermal 
      papilla cells (DPC-Exos), the overexpression and silencing of Wnt3a, could 
      regulate the Wnt/beta-catenin signaling pathway downstream genes. After collecting 
      DPC-Exos(OE-Wnt3a), the treatment of HFSC with DPC-Exos(OE-Wnt3a) showed that 
      DPC-Exos(OE-Wnt3a) could upregulate the mRNA expression of downstream genes in 
      the Wnt/beta-catenin signaling pathway and that DPC-Exos(OE-Wnt3a) enhanced the 
      proliferation of HFSCs while inhibiting their apoptosis. These findings suggest 
      that DPC-Exos could regulate HFSC cell proliferation via the Wnt3a/beta-catenin 
      signaling pathway. This research offers novel concepts for the molecular breeding 
      and efficient production of Angora rabbits, as well as for the treatment of human 
      hair problems.
CI  - Copyright (c) 2022 Jiali Li et al.
FAU - Li, Jiali
AU  - Li J
AUID- ORCID: 0000-0002-9854-0587
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 
      China.
FAU - Zhao, Bohao
AU  - Zhao B
AUID- ORCID: 0000-0003-3333-1001
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 
      China.
AD  - Joint International Research Laboratory of Agriculture & Agri-Product Safety, 
      Yangzhou University, Yangzhou, Jiangsu, China.
FAU - Dai, Yingying
AU  - Dai Y
AUID- ORCID: 0000-0003-2054-6425
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 
      China.
FAU - Zhang, Xiyu
AU  - Zhang X
AUID- ORCID: 0000-0002-3872-1503
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 
      China.
FAU - Chen, Yang
AU  - Chen Y
AUID- ORCID: 0000-0001-9097-5132
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 
      China.
AD  - Joint International Research Laboratory of Agriculture & Agri-Product Safety, 
      Yangzhou University, Yangzhou, Jiangsu, China.
FAU - Wu, Xinsheng
AU  - Wu X
AUID- ORCID: 0000-0001-9871-0251
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 
      China.
AD  - Joint International Research Laboratory of Agriculture & Agri-Product Safety, 
      Yangzhou University, Yangzhou, Jiangsu, China.
LA  - eng
SI  - figshare/10.6084/m9.figshare.20292390
PT  - Journal Article
DEP - 20221107
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (beta Catenin)
RN  - 0 (WNT3A protein, human)
RN  - 0 (Wnt3A Protein)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Rabbits
MH  - *beta Catenin/metabolism
MH  - Hair Follicle
MH  - *Exosomes/metabolism
MH  - Wnt Signaling Pathway
MH  - Cell Proliferation
MH  - Wnt3A Protein/genetics/metabolism
PMC - PMC9663250
COIS- The authors declare that they have no competing interests.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/22 06:00
PMCR- 2022/11/07
CRDT- 2022/11/17 12:08
PHST- 2022/07/15 00:00 [received]
PHST- 2022/08/25 00:00 [revised]
PHST- 2022/10/14 00:00 [accepted]
PHST- 2022/11/17 12:08 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2022/11/07 00:00 [pmc-release]
AID - 10.1155/2022/9042345 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2022 Nov 7;2022:9042345. doi: 10.1155/2022/9042345. 
      eCollection 2022.