PMID- 36388772
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221119
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 10
IP  - 20
DP  - 2022 Oct
TI  - Epidemic characteristics of Mycoplasma pneumoniae infection: a retrospective 
      analysis of a single center in Suzhou from 2014 to 2020.
PG  - 1123
LID - 10.21037/atm-22-4304 [doi]
LID - 1123
AB  - BACKGROUND: Mycoplasma pneumoniae (M. Pneumoniae) is a common pathogen of 
      respiratory tract infections, but there is still a lack of detailed investigation 
      on the large sample of M. Pneumoniae infection in the all age population. And 
      patients with severe M. Pneumoniae pneumonia (SMPP) still have a certain risk of 
      death. How to identify the clinical characteristics and population of patients 
      with SMPP as soon as possible is still an urgent problem in clinical practice. 
      METHODS: Demographic characteristics, patient clinical information, and 
      laboratory data of 81,131 patients with respiratory tract infections (RTIs) in 
      the Affiliated Suzhou Hospital of Nanjing Medical University from 2014 to 2020 
      were retrospectively collected from all patient records. The serum particle 
      agglutination (PA) test was used to determine M. Pneumoniae infection by 
      detecting specific antibodies. The white blood cell count, the proportion of 
      neutrophils and lymphocytes, C-reactive protein (CRP) and lactate dehydrogenase 
      (LDH) levels between children and adults with SMPP were compared by Student's 
      t-test; other clinical features were analyzed by chi(2) test or Fisher's exact 
      test. RESULTS: A total of 81,131 patients with RTIs were included, and 21,582 
      (26.60%) M. Pneumoniae immunoglobulin M (IgM)-positive patients were detected. 
      From 2014 to 2020, the annual proportions of M. Pneumoniae RTIs were 23.60%, 
      28.18%, 38.08%, 27.05%, 23.44%, 25.26%, and 18.33%, respectively. In terms of 
      seasonal distribution, April-June and September-November were the peak seasons of 
      M. Pneumoniae infection each year. Children and women have a high proportion of 
      M. Pneumoniae infection. The peak age of M. Pneumoniae infection was between 4 
      and 14 years old. There were 301 cases of SMPP, including 281 children and 20 
      adults (8 cases of pregnant women). Children and pregnant women accounted for a 
      high proportion of SMPP. Children with SMPP had more extrapulmonary symptoms, 
      multilobar infiltrates, and increased CRP and LDH levels compared with adults. 
      CONCLUSIONS: M. Pneumoniae infection has seasonal, sex, and age distribution 
      trends. Children and pregnant women accounted for a high proportion of SMPP. 
      Extrapulmonary symptoms, multilobar infiltrates, and increased CRP and LDH levels 
      may be helpful to identify SMPP in children than in adults.
CI  - 2022 Annals of Translational Medicine. All rights reserved.
FAU - Lv, Yan-Tian
AU  - Lv YT
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Soochow University, Suzhou, China.
AD  - Department of Respiratory and Critical Medicine, Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou, China.
FAU - Sun, Xiao-Jing
AU  - Sun XJ
AD  - Department of Pathology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Chen, Ying
AU  - Chen Y
AD  - Department of Respiratory and Critical Medicine, Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou, China.
FAU - Ruan, Ting
AU  - Ruan T
AD  - Department of Respiratory and Critical Medicine, Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou, China.
FAU - Xu, Guo-Peng
AU  - Xu GP
AD  - Department of Respiratory and Critical Medicine, Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou, China.
FAU - Huang, Jian-An
AU  - Huang JA
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Soochow University, Suzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC9652570
OTO - NOTNLM
OT  - Mycoplasma pneumoniae (M. Pneumoniae)
OT  - children
OT  - pregnant women
OT  - respiratory tract infection (RTI)
OT  - severe Mycoplasma pneumoniae pneumonia (SMPP)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://atm.amegroups.com/article/view/10.21037/atm-22-4304/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/18 06:01
PMCR- 2022/10/01
CRDT- 2022/11/17 12:17
PHST- 2022/08/12 00:00 [received]
PHST- 2022/10/09 00:00 [accepted]
PHST- 2022/11/17 12:17 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/18 06:01 [medline]
PHST- 2022/10/01 00:00 [pmc-release]
AID - atm-10-20-1123 [pii]
AID - 10.21037/atm-22-4304 [doi]
PST - ppublish
SO  - Ann Transl Med. 2022 Oct;10(20):1123. doi: 10.21037/atm-22-4304.