PMID- 36389058 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221119 IS - 1663-4365 (Print) IS - 1663-4365 (Electronic) IS - 1663-4365 (Linking) VI - 14 DP - 2022 TI - Neuroanatomical correlates of screening for aphasia in NeuroDegeneration (SAND) battery in non-fluent/agrammatic variant of primary progressive aphasia. PG - 942095 LID - 10.3389/fnagi.2022.942095 [doi] LID - 942095 AB - BACKGROUND: Non-fluent/agrammatic variant of Primary Progressive Aphasia (avPPA) is primarily characterized by language impairment due to atrophy of the inferior frontal gyrus and the insula cortex in the dominant hemisphere. The Screening for Aphasia in NeuroDegeneration (SAND) battery has been recently proposed as a screening tool for PPA, with several tasks designed to be specific for different language features. Applying multivariate approaches to neuroimaging data and verbal fluency tasks, Aachener Aphasie Test (AAT) naming subtest and SAND data may help in elucidating the neuroanatomical correlates of language deficits in avPPA. OBJECTIVE: To investigate the neuroanatomical correlates of language deficits in avPPA using verbal fluency tasks, AAT naming subtest and SAND scores as proxies of brain structural imaging abnormalities. METHODS: Thirty-one avPPA patients were consecutively enrolled and underwent extensive neuropsychological assessment and MRI scan. Raw scores of verbal fluency tasks, AAT naming subtest, and SAND subtests, namely living and non-living picture naming, auditory sentence comprehension, single-word comprehension, words and non-words repetition and sentence repetition, were used as proxies to explore structural (gray matter volume) neuroanatomical correlates. We assessed univariate (voxel-based morphometry, VBM) as well as multivariate (source-based morphometry, SBM) approaches. Age, gender, educational level, and disease severity were considered nuisance variables. RESULTS: SAND picture naming (total, living and non-living scores) and AAT naming scores showed a direct correlation with the left temporal network derived from SBM. At univariate analysis, the left middle temporal gyrus was directly correlated with SAND picture naming (total and non-living scores) and AAT naming score. When words and non-words repetition (total score) was considered, a direct correlation with the left temporal network (SBM) and with the left fusiform gyrus (VBM) was also evident. CONCLUSION: Naming impairments that characterize avPPA are related to specific network-based involvement of the left temporal network, potentially expanding our knowledge on the neuroanatomical basis of this neurodegenerative condition. CI - Copyright (c) 2022 Premi, Cotelli, Gobbi, Pagnoni, Binetti, Gadola, Libri, Mattioli, Pengo, Iraji, Calhoun, Alberici, Borroni and Manenti. FAU - Premi, Enrico AU - Premi E AD - Stroke Unit, Azienda Socio Sanitaria Territoriale Spedali Civili Brescia, Brescia, Italy. FAU - Cotelli, Maria AU - Cotelli M AD - Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. FAU - Gobbi, Elena AU - Gobbi E AD - Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. FAU - Pagnoni, Ilaria AU - Pagnoni I AD - Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. FAU - Binetti, Giuliano AU - Binetti G AD - MAC Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. FAU - Gadola, Yasmine AU - Gadola Y AD - Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Owensboro, Italy. FAU - Libri, Ilenia AU - Libri I AD - Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Owensboro, Italy. FAU - Mattioli, Irene AU - Mattioli I AD - Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Owensboro, Italy. FAU - Pengo, Marta AU - Pengo M AD - Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Owensboro, Italy. FAU - Iraji, Armin AU - Iraji A AD - Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia Institute of Technology, Georgia State University, Emory University, Atlanta, GA, United States. AD - Departments of Psychology and Computer Science, Georgia State University, Atlanta, GA, United States. FAU - Calhoun, Vince D AU - Calhoun VD AD - Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia Institute of Technology, Georgia State University, Emory University, Atlanta, GA, United States. AD - Departments of Psychology and Computer Science, Georgia State University, Atlanta, GA, United States. AD - Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States. FAU - Alberici, Antonella AU - Alberici A AD - Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Owensboro, Italy. FAU - Borroni, Barbara AU - Borroni B AD - Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Owensboro, Italy. FAU - Manenti, Rosa AU - Manenti R AD - Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. LA - eng PT - Journal Article DEP - 20221031 PL - Switzerland TA - Front Aging Neurosci JT - Frontiers in aging neuroscience JID - 101525824 PMC - PMC9660243 OTO - NOTNLM OT - frontotemporal lobar degeneration OT - imaging OT - language OT - primary progressive aphasia OT - source-based morphometry (SBM) OT - voxel-based morphometry (VBM) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/11/18 06:00 MHDA- 2022/11/18 06:01 PMCR- 2022/01/01 CRDT- 2022/11/17 12:20 PHST- 2022/05/12 00:00 [received] PHST- 2022/10/11 00:00 [accepted] PHST- 2022/11/17 12:20 [entrez] PHST- 2022/11/18 06:00 [pubmed] PHST- 2022/11/18 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fnagi.2022.942095 [doi] PST - epublish SO - Front Aging Neurosci. 2022 Oct 31;14:942095. doi: 10.3389/fnagi.2022.942095. eCollection 2022.