PMID- 36389660
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20230411
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Intracellular monitoring by dendritic cells - a new way to stay informed - from a 
      simple scavenger to an active gatherer.
PG  - 1053582
LID - 10.3389/fimmu.2022.1053582 [doi]
LID - 1053582
AB  - Dendritic cells (DCs) are required for the initiation of the adaptive immune 
      response. Their ability to acquire antigens in the periphery is a critical step 
      in this process. DCs express a wide variety of adhesion molecules and possess an 
      extremely fluid plasma membrane that facilitates scavenging the extracellular 
      environment and capturing material like exosomes, apoptotic bodies, and 
      pathogens. Besides these standard routes, the acquisition of antigens by DCs can 
      be further facilitated by tunneling nanotubes, trogocytosis, and gap junctions. 
      However, in this article, we will argue that this is an incomplete picture, as 
      certain observations in the literature cannot be explained if we assume DCs 
      acquire antigens only through these means. Instead, it is more likely that DCs 
      preferentially use adhesion molecules to form long-lasting cell-cell interactions 
      to actively siphon material from cells they are in direct contact with. It is 
      highly likely that DCs use this mechanism to continually capture membrane and 
      cytosolic material directly from surrounding cells, which they scan to assess the 
      health of the donor cell. Doing so would provide an array of advantages for the 
      host immune system, as it would not be reliant on compromised cells to release 
      antigens into the extracellular milieu. Therefore, we propose updating our view 
      of DC antigen acquisition to include a process of active, contact-dependent 
      capture of material directly from neighboring cell cytosol (cytocytosis), which 
      we would term intracellular monitoring.
CI  - Copyright (c) 2022 Herbst, Harshyne and Igyarto.
FAU - Herbst, Christopher
AU  - Herbst C
AD  - Department of Microbiology and Immunology, Thomas Jefferson University, 
      Philadelphia, PA, United States.
FAU - Harshyne, Larry A
AU  - Harshyne LA
AD  - Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, 
      United States.
FAU - Igyarto, Botond Z
AU  - Igyarto BZ
AD  - Department of Microbiology and Immunology, Thomas Jefferson University, 
      Philadelphia, PA, United States.
LA  - eng
GR  - R01 AI146420/AI/NIAID NIH HHS/United States
GR  - R01 AI146101/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20221027
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Dendritic Cells
MH  - Cell Communication
MH  - Adaptive Immunity
MH  - *Exosomes
MH  - *Extracellular Vesicles
PMC - PMC9647004
OTO - NOTNLM
OT  - antigen uptake/presentation
OT  - dendritic cells
OT  - intracellular monitoring
OT  - scavenging
OT  - surveillance
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/22 06:00
PMCR- 2022/01/01
CRDT- 2022/11/17 12:42
PHST- 2022/09/25 00:00 [received]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/17 12:42 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.1053582 [doi]
PST - epublish
SO  - Front Immunol. 2022 Oct 27;13:1053582. doi: 10.3389/fimmu.2022.1053582. 
      eCollection 2022.