PMID- 36393912
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221119
IS  - 2451-9936 (Electronic)
IS  - 2451-9936 (Linking)
VI  - 28
DP  - 2022 Dec
TI  - Lurbinectedin improves macular edema in a case of central retinal vein occlusion.
PG  - 101743
LID - 10.1016/j.ajoc.2022.101743 [doi]
LID - 101743
AB  - PURPOSE: To evaluate the response to lurbinectedin in a case of macular edema, 
      secondary to central retinal vein occlusion (CRVO). Serial spectral domain 
      optical coherence tomography (SD-OCT) scans were taken in a 70-year-old man with 
      a 24-month history of macular edema secondary to CRVO in the right eye. The 
      patient underwent 5 cycles of chemotherapy with lurbinectedin between October 
      2018 and May 2019. Central macular thickness (CMT) before and after each 
      chemotherapy cycle was measured together with progression analysis using the 
      CIRRUS Zeiss software. OBSERVATIONS: SD-OCT showed alternating recurrence and 
      resolution of macular edema closely related to the chemotherapy administrations. 
      CMT oscillated between 496 and 284 mum during the follow-up. The macular edema was 
      showed to decrease as soon as 4 days following chemotherapy. CONCLUSIONS AND 
      IMPORTANCE: Resolution of macular edema associated with CRVO was seen in our 
      patient whilst undergoing chemotherapy with lurbinectedin. Lurbinectedin may play 
      a role in the treatment of macular edema secondary to CRVO and may open new 
      therapeutic indication for this natural marine molecule.
CI  - (c) 2022 The Authors.
FAU - Simona, Filippo
AU  - Simona F
AD  - PAX Eye Center, Locarno, Switzerland.
FAU - Menna, Feliciana
AU  - Menna F
AD  - PAX Eye Center, Locarno, Switzerland.
FAU - Wannesson, Luciano
AU  - Wannesson L
AD  - Istituto Oncologico della Svizzera Italiana (IOSI), Bellinzona, Switzerland.
FAU - Meduri, Alessandro
AU  - Meduri A
AD  - Biomedical, Dental and Morphological and Functional Images Sciences, Department, 
      University of Messina, Messina, Italy.
FAU - De Salvo, Gabriella
AU  - De Salvo G
AD  - Ophthalmology Department, University Hospital Southampton Foundation Trust, 
      Southampton, United Kingdom.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - IRCCS San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy.
LA  - eng
PT  - Case Reports
DEP - 20221106
PL  - United States
TA  - Am J Ophthalmol Case Rep
JT  - American journal of ophthalmology case reports
JID - 101679941
PMC - PMC9650020
OTO - NOTNLM
OT  - 1-central retinal vein occlusion
OT  - Keyword 2-lurbinectedin
OT  - Keyword 3- macular edema
OT  - Keyword 4
OT  - Keyword 5
OT  - Natural anticancer drugs
OT  - Optical coherence tomography
COIS- The authors have no proprietary or commercial interest in any materials Discussed 
      in this article. No conflicting relationship exists for any author. No competing 
      interests among authors.
EDAT- 2022/11/18 06:00
MHDA- 2022/11/18 06:01
PMCR- 2022/11/06
CRDT- 2022/11/17 13:11
PHST- 2022/06/18 00:00 [received]
PHST- 2022/10/23 00:00 [revised]
PHST- 2022/11/01 00:00 [accepted]
PHST- 2022/11/17 13:11 [entrez]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/18 06:01 [medline]
PHST- 2022/11/06 00:00 [pmc-release]
AID - S2451-9936(22)00489-3 [pii]
AID - 101743 [pii]
AID - 10.1016/j.ajoc.2022.101743 [doi]
PST - epublish
SO  - Am J Ophthalmol Case Rep. 2022 Nov 6;28:101743. doi: 10.1016/j.ajoc.2022.101743. 
      eCollection 2022 Dec.