PMID- 36393972 OWN - NLM STAT- MEDLINE DCOM- 20221121 LR - 20221121 IS - 1875-8630 (Electronic) IS - 0278-0240 (Print) IS - 0278-0240 (Linking) VI - 2022 DP - 2022 TI - Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome. PG - 2193343 LID - 10.1155/2022/2193343 [doi] LID - 2193343 AB - BACKGROUND: Previous studies have shown that increased mean corpuscular volume (MCV) is an independent predictor for worse outcomes in coronary artery disease. However, as parameters to classify different types of anemia together with MCV, the relationship between mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and long-term outcomes in acute coronary syndrome (ACS) remains obscure. Moreover, few studies have compared the prognostic value of these red blood cell indices in anemic and nonanemic patients with ACS. METHODS AND RESULTS: In this single-center observational cohort study, we enrolled 393 patients diagnosed with ACS, including 75 anemic and 318 nonanemic patients. The composite end points were defined as major adverse cardiovascular events (MACEs). After a median follow-up of 31.24 months, Kaplan-Meier survival analysis showed that higher MCV and MCH but not MCHC were significantly associated with increased MACEs in nonanemic ACS patients. Among the enrolled ACS patients without anemia, Cox regression analysis revealed that high MCV and MCH were correlated with increased MACEs after adjustment for cardiovascular risk factors, and receiver operating characteristic (ROC) curve analysis further confirmed the predictive value of high MCV and MCH. In bivariate correlation and linear regression analysis, plasma homocysteine was positively correlated with MCV and MCH but not MCHC in the nonanemic group even after adjusting for age, male sex, BMI, SBP, DBP, smoking, and diabetes. However, MCV, MCH, and MCHC showed no predictive value for MACEs, and no correlation was found between these red blood cell indices and homocysteine in ACS patients with anemia. CONCLUSION: After adjusting for cardiovascular risk factors, this study showed that higher admission MCV and MCH but not MCHC were independent predictors for long-term MACEs and positively correlated with homocysteine levels in the blood among the nonanemic but not anemic patients with ACS in China. CI - Copyright (c) 2022 Zhanyi Zhang et al. FAU - Zhang, Zhanyi AU - Zhang Z AUID- ORCID: 0000-0002-5240-8521 AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Gao, Shanshan AU - Gao S AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Dong, Mengya AU - Dong M AD - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China. FAU - Luo, Jian AU - Luo J AD - Health Management Center, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, Shaanxi, China. FAU - Xu, Chenbo AU - Xu C AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Wen, Wen AU - Wen W AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Huang, Yuzhi AU - Huang Y AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Wu, Yue AU - Wu Y AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Zhou, Juan AU - Zhou J AUID- ORCID: 0000-0002-4711-9872 AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Yuan, Zuyi AU - Yuan Z AUID- ORCID: 0000-0002-7341-6889 AD - Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. LA - eng PT - Journal Article PT - Observational Study DEP - 20221103 PL - United States TA - Dis Markers JT - Disease markers JID - 8604127 RN - 0LVT1QZ0BA (Homocysteine) SB - IM MH - Humans MH - Male MH - Erythrocyte Indices MH - *Acute Coronary Syndrome/complications/diagnosis MH - *Anemia/complications MH - Erythrocytes MH - Homocysteine PMC - PMC9649320 COIS- The authors declare that there is no conflict of interest regarding the publication of this paper. EDAT- 2022/11/18 06:00 MHDA- 2022/11/22 06:00 PMCR- 2022/11/03 CRDT- 2022/11/17 13:11 PHST- 2022/04/25 00:00 [received] PHST- 2022/09/28 00:00 [revised] PHST- 2022/10/21 00:00 [accepted] PHST- 2022/11/17 13:11 [entrez] PHST- 2022/11/18 06:00 [pubmed] PHST- 2022/11/22 06:00 [medline] PHST- 2022/11/03 00:00 [pmc-release] AID - 10.1155/2022/2193343 [doi] PST - epublish SO - Dis Markers. 2022 Nov 3;2022:2193343. doi: 10.1155/2022/2193343. eCollection 2022.