PMID- 36395042
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230719
IS  - 1936-2293 (Electronic)
IS  - 1064-1297 (Linking)
VI  - 31
IP  - 4
DP  - 2023 Aug
TI  - Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and 
      female rats.
PG  - 868-879
LID - 10.1037/pha0000610 [doi]
AB  - The use of both prescription and illicit drugs creates the potential for drug 
      interactions as a function of both pharmacokinetic and pharmacodynamic processes. 
      One such interaction is that of fluoxetine and methylenedioxymethamphetamine 
      (MDMA) in which fluoxetine attenuates the positive-like effects of MDMA. The 
      present work extends the analysis of their interaction by examining the impact of 
      fluoxetine on the aversive effects of MDMA which in balance with its rewarding 
      effects may mediate its abuse potential. Male and female Sprague-Dawley rats were 
      given fluoxetine (10 mg/kg every 4th day for five injections) prior to taste 
      avoidance training with MDMA (3.2 mg/kg). MDMA induced taste avoidance in males 
      and females (faster acquisition in females). Fluoxetine preexposure attenuated 
      this avoidance in males, but not females. For males, the attenuation was partial 
      as MDMA-conditioned animals with fluoxetine preexposure still displayed a 
      significant reduction in fluid intake compared to controls. Consistent with prior 
      work assessing the interaction of fluoxetine and MDMA, fluoxetine preexposure 
      impacted the ability of MDMA to support taste avoidance learning, specifically 
      attenuating the aversive effect of the drug. Prior work has shown that fluoxetine 
      attenuates MDMA's positive effects which might lead to reduced intake of the 
      drug; however, the concurrent reduction in the drug's aversive effects may still 
      shift the overall affective balance of these two affective properties toward 
      continued use and abuse. The fact that the attenuation was only evident in males 
      needs further study to investigate the sex-dependent effects of drug history. 
      (PsycInfo Database Record (c) 2023 APA, all rights reserved).
FAU - Bowman, Sara K
AU  - Bowman SK
AUID- ORCID: 0000-0003-3548-0115
AD  - Psychopharmacology Laboratory, American University.
FAU - Huang, Shihui
AU  - Huang S
AUID- ORCID: 0000-0002-8565-3670
AD  - Psychopharmacology Laboratory, American University.
FAU - Vasquez, Marissa E
AU  - Vasquez ME
AUID- ORCID: 0000-0003-4682-0023
AD  - Psychopharmacology Laboratory, American University.
FAU - Rice, Kenner C
AU  - Rice KC
AUID- ORCID: 0000-0002-1147-9147
AD  - Drug Design and Synthesis Section, National Institute on Drug Abuse (NIDA).
FAU - Riley, Anthony L
AU  - Riley AL
AUID- ORCID: 0000-0003-3770-0652
AD  - Psychopharmacology Laboratory, American University.
LA  - eng
PT  - Journal Article
DEP - 20221117
PL  - United States
TA  - Exp Clin Psychopharmacol
JT  - Experimental and clinical psychopharmacology
JID - 9419066
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Fluoxetine/pharmacology
MH  - Rats, Sprague-Dawley
MH  - Taste
MH  - Avoidance Learning
EDAT- 2022/11/18 06:00
MHDA- 2023/07/19 06:42
CRDT- 2022/11/17 14:10
PHST- 2023/07/19 06:42 [medline]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2022/11/17 14:10 [entrez]
AID - 2023-18685-001 [pii]
AID - 10.1037/pha0000610 [doi]
PST - ppublish
SO  - Exp Clin Psychopharmacol. 2023 Aug;31(4):868-879. doi: 10.1037/pha0000610. Epub 
      2022 Nov 17.