PMID- 36396595
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230321
IS  - 2530-0180 (Electronic)
IS  - 2530-0180 (Linking)
VI  - 70 Suppl 1
DP  - 2023 Mar
TI  - Indications for genetic study in gastro-entero-pancreatic and thoracic 
      neuroendocrine tumors.
PG  - 63-73
LID - S2530-0180(22)00178-0 [pii]
LID - 10.1016/j.endien.2022.11.014 [doi]
AB  - Gastro-entero-pancreatic (GEP-NET) and thoracic neuroendocrine tumours (NETs) are 
      one of the most heritable groups of neoplasms in the body, being multiple 
      endocrine neoplasia syndrome type 1 (MEN1), the genetic syndrome most frequently 
      associated with this type of tumours. Moreover, Von Hippel Lindau syndrome, 
      tuberous sclerosis, type 4 multiple neoplasia syndrome, and type 1 
      neurofibromatosis are associated with an increased risk of developing GEP-NETs. 
      Another important aspect in GEP-NETs and thoracic NETs is the knowledge of the 
      molecular background since the molecular profile of these tumours may have 
      implications in the prognosis and in the response to specific treatments. This 
      review summarizes the main indications for performing a genetic study in patients 
      with GEP-NETs and thoracic NETs, and the methods used to carry it out. Moreover, 
      it offers a description of the main hereditary syndromes associated with these 
      NETs and their molecular background, as well as the clinical implications of the 
      molecular profile.
CI  - Copyright (c) 2022 SEEN and SED. Published by Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Araujo-Castro, Marta
AU  - Araujo-Castro M
AD  - Unidad de Neuroendocrinologia, Departamento de Endocrinologia y Nutricion, 
      Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Invesitigacion 
      Sanitaria (IRYCIS), Madrid, Spain; Departamento de Medicina, Universidad de 
      Alcala, Madrid, Spain. Electronic address: marta.araujo@salud.madrid.org.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221114
PL  - Spain
TA  - Endocrinol Diabetes Nutr (Engl Ed)
JT  - Endocrinologia, diabetes y nutricion
JID - 101717565
SB  - IM
MH  - Humans
MH  - *Neuroendocrine Tumors/genetics/pathology
MH  - *Pancreatic Neoplasms/genetics
MH  - *Stomach Neoplasms
MH  - *Intestinal Neoplasms/genetics
MH  - *Multiple Endocrine Neoplasia Type 1/genetics
OTO - NOTNLM
OT  - Bronchial carcinoids
OT  - Carcinoides bronquiales
OT  - Carcinoides timicos
OT  - Gastro-entero-pancreatic neuroendocrine tumours
OT  - Multiple endocrine neoplasia syndrome type 1
OT  - Neuroendocrine tumours
OT  - Sindrome de Von Hippel Lindau
OT  - Sindrome de neoplasia endocrina multiple tipo 1
OT  - Thymic carcinoids
OT  - Tumores neuroendocrinos
OT  - Tumores neuroendocrinos gastro entero-pancreaticos
OT  - Von Hippel Lindau syndrome
EDAT- 2022/11/18 06:00
MHDA- 2023/03/22 06:00
CRDT- 2022/11/17 22:10
PHST- 2021/10/13 00:00 [received]
PHST- 2022/04/03 00:00 [accepted]
PHST- 2022/11/18 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2022/11/17 22:10 [entrez]
AID - S2530-0180(22)00178-0 [pii]
AID - 10.1016/j.endien.2022.11.014 [doi]
PST - ppublish
SO  - Endocrinol Diabetes Nutr (Engl Ed). 2023 Mar;70 Suppl 1:63-73. doi: 
      10.1016/j.endien.2022.11.014. Epub 2022 Nov 14.