PMID- 36397312
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20221121
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 14
IP  - 45
DP  - 2022 Nov 16
TI  - Cell-Membrane-Coated Cationic Nanoparticles Disguised as Macrophages for the 
      Prevention and Treatment of Type 2 Diabetes Mellitus.
PG  - 50499-50506
LID - 10.1021/acsami.2c12218 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by 
      low-grade inflammation and insulin resistance. In this process, innate immune 
      cells play a crucial role in recognizing the stimuli (free fatty acid, 
      lipopolysaccharide, and cytokines) and mediating the inflammatory response, 
      contributing to the development of T2DM. Neutralizing inflammatory cytokines and 
      blocking the inflammation cascade provide great potential for the treatment of 
      T2DM. Here, we applied a macrophage membrane as a bait, which could specifically 
      recognize and bind the stimuli, to encapsulate nanoparticles and capture the 
      stimuli, further preventing inflammation. The in vivo experiment results suggest 
      that the nanoparticles could reduce the production of proinflammatory cytokines, 
      decrease insulin resistance, and realize significant therapeutic effects for 
      T2DM. A potential strategy is thus offered for blocking immune response, holding 
      a wide application in metabolic and autoimmune diseases.
FAU - Wu, Lin
AU  - Wu L
AD  - Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
FAU - Yuan, Anran
AU  - Yuan A
AD  - Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Tian, Xiangrong
AU  - Tian X
AD  - Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Cao, Jin
AU  - Cao J
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Qi, Xueyong
AU  - Qi X
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Wei, Yuan
AU  - Wei Y
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Shen, Song
AU  - Shen S
AUID- ORCID: 0000-0002-8762-0397
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
LA  - eng
PT  - Journal Article
DEP - 20221103
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy/prevention & control
MH  - *Insulin Resistance/physiology
MH  - Macrophages/metabolism
MH  - Inflammation/metabolism
MH  - Cytokines/metabolism
MH  - *Nanoparticles/therapeutic use
OTO - NOTNLM
OT  - T2DM
OT  - cytokines neutralization
OT  - disguised nanoparticles
OT  - inflammation
OT  - macrophages
EDAT- 2022/11/19 06:00
MHDA- 2022/11/22 06:00
CRDT- 2022/11/18 01:02
PHST- 2022/11/18 01:02 [entrez]
PHST- 2022/11/19 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
AID - 10.1021/acsami.2c12218 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2022 Nov 16;14(45):50499-50506. doi: 
      10.1021/acsami.2c12218. Epub 2022 Nov 3.