PMID- 36397865
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221119
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 10
IP  - 11
DP  - 2022 Nov
TI  - Subepithelial tumors: How does endoscopic full-thickness resection & submucosal 
      tunneling with endoscopic resection compare with laparoscopic endoscopic 
      cooperative surgery?
PG  - E1491-E1496
LID - 10.1055/a-1922-7890 [doi]
AB  - Background and study aims  Endoscopic techniques are rapidly emerging for 
      resection of subepithelial tumors (SETs). Submucosal tunneling for endoscopic 
      resection (STER), endoscopic full-thickness resection (EFTR) and laparoscopic 
      endoscopic cooperative surgery (LECS) are current alternatives to open surgery. 
      In this study, we aimed to compare the three endoscopic techniques. Patients and 
      methods  Consecutive patients who underwent resection of a submucosal esophageal 
      or gastric lesion at several tertiary care centers were included in a dedicated 
      registry over 3 years. Demographics, size and location of resected lesion, 
      histology of specimen, length of procedure, adverse events (AEs), duration of 
      hospital stay, and follow-up data were collected. Results  Ninety-six patients 
      were included (47.7 % male, mean age 62): STER n = 34, EFTR n = 34, LECS 
      n = 280. The lesions included leiomyoma, gastrointestinal stromal tumors (GISTs) 
      and other. The mean lesion size was 28 mm (STD 16, range 20-72 mm). The majority 
      of lesions in the EFTR and laparoscopic-assisted resection group were GISTs. 
      There was no significant difference in clear resection margins, post-procedure 
      complication rates, recurrence rate and total follow-up duration between the 
      groups. However, the LECS group had a procedure time at least 30 minutes longer 
      than STER or EFTR ( P  < 0.01). Total hospital stay for the laparoscopic-assisted 
      resection group was also longer when compared to STER (1.5) and EFTR (1.8) ( P 
       < 0.01). Conclusions  STER, EFTR, and laparoscopic-assisted resection are 
      efficacious approaches for resection of SETs with similar R0 resection rates, 
      complication rates, and AE rates. Laparoscopic assisted resection appears more 
      time-consuming and is associated with a longer hospital stay.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Kahaleh, Michel
AU  - Kahaleh M
AUID- ORCID: 0000-0003-0836-6114
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Bhagat, Vicky
AU  - Bhagat V
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Dellatore, Peter
AU  - Dellatore P
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Tyberg, Amy
AU  - Tyberg A
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Sarkar, Avik
AU  - Sarkar A
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Shahid, Haroon M
AU  - Shahid HM
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Andalib, Iman
AU  - Andalib I
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Alkhiari, Resheed
AU  - Alkhiari R
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Gaidhane, Monica
AU  - Gaidhane M
AD  - Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, 
      United States.
FAU - Kedia, Prashant
AU  - Kedia P
AD  - Gastroenterology, Methodist Hospital, Dallas, Texas, United States.
FAU - Nieto, Jose
AU  - Nieto J
AD  - Borland-Groover Clinic, Jacksonville, Florida, United States.
FAU - Kumta, Nikhil A
AU  - Kumta NA
AD  - Gastroenterology, Mount Sinai Hospital, New York, New York, United States.
FAU - Dixon, Rebekah E
AU  - Dixon RE
AD  - Gastroenterology, Mount Sinai Hospital, New York, New York, United States.
FAU - Salameh, Habeeb
AU  - Salameh H
AD  - Gastroenterology, Mount Sinai Hospital, New York, New York, United States.
FAU - Mavrogenis, Georgios
AU  - Mavrogenis G
AD  - Gastroenterology, Mytilene Hospital, Mytilene, Greece.
FAU - Bassioukas, Stefanos
AU  - Bassioukas S
AD  - Gastroenterology, Latpikin, Athens, Greece.
FAU - Abe, Seiichiro
AU  - Abe S
AUID- ORCID: 0000-0002-2736-6921
AD  - Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
FAU - Arentes, Vitor N
AU  - Arentes VN
AD  - Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - Morita, Flavio H
AU  - Morita FH
AD  - Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Sakai, Paulo
AU  - Sakai P
AD  - Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - de Moura, Eduardo G
AU  - de Moura EG
AUID- ORCID: 0000-0002-8023-3722
AD  - Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20221115
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC9666078
COIS- Competing interests Avik Sarkar has done consulting work for US Endoscopy and 
      Obalon Therapeutics. Haroon Shahid has done consulting work for US Endoscopy. Amy 
      Tyberg has done consulting work for NinePoint Medical, EndoGastric Solutions, and 
      Obalon Therapeutics. Michel Kahaleh has done consulting work for Boston 
      Scientific, Interscope Med, and Abbvie. He has received research grants from 
      Boston Scientific, Emcision, Conmed, Pinnacle, Cook, Gore, Merit, and Olympus. 
      Monica Gaidhane has done consulting for 3D Matrix
EDAT- 2022/11/19 06:00
MHDA- 2022/11/19 06:01
PMCR- 2022/11/01
CRDT- 2022/11/18 02:06
PHST- 2021/03/03 00:00 [received]
PHST- 2022/08/10 00:00 [accepted]
PHST- 2022/11/18 02:06 [entrez]
PHST- 2022/11/19 06:00 [pubmed]
PHST- 2022/11/19 06:01 [medline]
PHST- 2022/11/01 00:00 [pmc-release]
AID - 10.1055/a-1922-7890 [doi]
PST - epublish
SO  - Endosc Int Open. 2022 Nov 15;10(11):E1491-E1496. doi: 10.1055/a-1922-7890. 
      eCollection 2022 Nov.