PMID- 36398853
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230314
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 38
IP  - 3
DP  - 2023 Mar
TI  - Endoscopic submucosal dissection for anastomotic lesions after colorectal 
      surgery.
PG  - 424-432
LID - 10.1111/jgh.16063 [doi]
AB  - BACKGROUND: Endoscopic submucosal dissection (ESD) for anastomotic lesions is 
      technically challenging. We aimed to characterize the clinicopathologic 
      characteristics, feasibility, and effectiveness of ESD for anastomotic lesions of 
      the lower gastrointestinal tract. METHOD: We retrospectively investigated 55 
      patients with anastomotic lesions of the lower gastrointestinal tract who 
      underwent ESD from February 2008 to January 2021. The lesions involving one or 
      both sides of anastomoses were classified into the unilaterally involving 
      anastomosis (UIA) or straddling anastomosis (SA) group, respectively. We 
      collected clinicopathological characteristics, procedure-related parameters and 
      outcomes, and follow-up data and analyzed the impact of anastomotic involvement. 
      RESULTS: The mean age was 62.5 years, and the median procedure duration was 
      30 min. The rates of en bloc resection and R0 resection were 90.9% and 85.5%, 
      respectively. Four patients (7.3%) experienced major adverse events (AEs). During 
      a median follow-up of 66 months (range 14-169), seven patients had local 
      recurrence, and six patients had metastases. The 5-year disease-free survival and 
      overall survival rates were 82.4% and 90.7%, respectively. The 5-year disease 
      -specific survival (DSS) rate was 93.3%. Compared with the UIA group, the SA 
      group had significantly longer procedure duration, larger specimen, lower rates 
      of en bloc resection and R0 resection, and shorter disease-free survival (all 
      P < 0.05). However, rates of AEs did not differ significantly between the two 
      groups. CONCLUSIONS: The short-term and long-term outcomes of ESD for colorectal 
      anastomotic lesions were favorable. Although with technically challenging, ESD 
      could be performed safely and effectively for lesions at the anastomoses.
CI  - (c) 2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & 
      Sons Australia, Ltd.
FAU - Wang, Li
AU  - Wang L
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Liu, Zu-Qiang
AU  - Liu ZQ
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Liu, Jing-Zheng
AU  - Liu JZ
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Ma, Li-Yun
AU  - Ma LY
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Li, Xiao-Qing
AU  - Li XQ
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Yao, Lu
AU  - Yao L
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Li, Quan-Lin
AU  - Li QL
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, China.
FAU - Zhou, Ping-Hong
AU  - Zhou PH
AUID- ORCID: 0000-0002-5434-0540
AD  - Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, China.
LA  - eng
GR  - 82170555/National Natural Science Foundation of China/
GR  - 82000507/National Natural Science Foundation of China/
GR  - 22XD1422400/Shanghai Academic/Technology Research Leader/
GR  - 20224Z0005/Shanghai "Rising Stars of Medical Talent" Youth Development Program/
GR  - S2020-016/Yangfan Program of Shanghai Municipal Science and Technology Committee/
GR  - 19441905200/Major Project of Shanghai Municipal Science and Technology Committee/
GR  - 2020ZSQN16/Youth Foundation of Zhongshan Hospital, Fudan University/
PT  - Journal Article
DEP - 20221211
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - *Endoscopic Mucosal Resection/methods
MH  - Retrospective Studies
MH  - *Colorectal Surgery
MH  - Disease-Free Survival
MH  - Anastomosis, Surgical
MH  - Treatment Outcome
MH  - *Colorectal Neoplasms/pathology
MH  - Neoplasm Recurrence, Local
OTO - NOTNLM
OT  - anastomosis
OT  - endoscopic submucosal dissection
OT  - lower gastrointestinal surgery
EDAT- 2022/11/19 06:00
MHDA- 2023/03/15 06:00
CRDT- 2022/11/18 07:43
PHST- 2022/11/10 00:00 [revised]
PHST- 2022/09/07 00:00 [received]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/11/19 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2022/11/18 07:43 [entrez]
AID - 10.1111/jgh.16063 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2023 Mar;38(3):424-432. doi: 10.1111/jgh.16063. Epub 
      2022 Dec 11.