PMID- 36400411
OWN - NLM
STAT- MEDLINE
DCOM- 20230127
LR  - 20230322
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 49
IP  - 1
DP  - 2023 Jan
TI  - Physical activity and diabetes mortality in people with type 2 diabetes: a 
      prospective cohort study of 0.5 million US people.
PG  - 101410
LID - S1262-3636(22)00091-X [pii]
LID - 10.1016/j.diabet.2022.101410 [doi]
AB  - AIM: To examine the association between physical activity and the cause of death 
      with the greatest risk related to type 2 diabetes mellitus (T2DM) in a large 
      population-based cohort representative of the general US adult population. 
      METHODS: A total of 41,726 adults suffering from T2DM (age 62 +/- 14 years) and 
      459,660 adults without diabetes (age 46 +/- 18 years) who participated in the 
      National Health Interview Survey from 1997 to 2014 were included in this 
      prospective cohort study. Self-reported moderate-to-vigorous physical activity 
      (MVPA) was categorized into inactive, insufficiently active, active and very 
      active. Mortality data was obtained from the National Death Index. Cox regression 
      models adjusted for potential confounders were performed to estimate hazard ratio 
      (HR) and 95% confidence interval (CI). RESULTS: Diabetes mortality cause showed 
      the highest relative risk of death among adults with T2DM compared to adults 
      without diabetes (HR 5.72 [3.15;10.39]). There was a non-linear inverse 
      dose-response association between MVPA and diabetes mortality among adults with 
      T2DM, up to a plateau in risk reduction at approximately 500 min/week. Any level 
      of activity was inversely associated with a significantly lower risk of diabetes 
      mortality compared with being inactive (insufficiently active HR 0.71[0.54;0.97], 
      active HR 0.68 [0.49;0.95], very active HR 0.44 [0.32;0.60]). Compared to adults 
      without diabetes, the risk of diabetes mortality decreased from HR 7.38 
      [4.00;13.58] for inactive people with T2DM to HR 3.34 [1.76;6.32] for very active 
      people with T2DM. CONCLUSIONS: Higher levels of MVPA were associated with lower 
      risk of diabetes mortality among adults with T2DM.
CI  - Copyright (c) 2022 Elsevier Masson SAS. All rights reserved.
FAU - Beltran-Valls, Maria Reyes
AU  - Beltran-Valls MR
AD  - LIFE Research Group, Universitat Jaume I, Castellon, Spain.
FAU - Cabanas-Sanchez, Veronica
AU  - Cabanas-Sanchez V
AD  - IMDEA-Food Institute, CEI UAM+CSIC, Madrid 28049, Spain. Electronic address: 
      veronica.cabanas84@gmail.com.
FAU - Sadarangani, Kabir P
AU  - Sadarangani KP
AD  - Escuela de Kinesiologia, Facultad de Salud y Odontologia, Universidad Diego 
      Portales, Santiago, Chile; Escuela de Kinesiologia, Facultad de Odontologia y 
      Ciencias de las Rehabilitacion, Universidad San Sebastian, Sede, Santiago, Chile.
FAU - Rodriguez-Artalejo, Fernando
AU  - Rodriguez-Artalejo F
AD  - IMDEA-Food Institute, CEI UAM+CSIC, Madrid 28049, Spain; Department of Preventive 
      Medicine and Public Health, School of Medicine, Universidad Autonoma de Madrid, 
      Madrid, Spain; CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.
FAU - Moliner-Urdiales, Diego
AU  - Moliner-Urdiales D
AD  - LIFE Research Group, Universitat Jaume I, Castellon, Spain.
FAU - Martinez-Gomez, David
AU  - Martinez-Gomez D
AD  - IMDEA-Food Institute, CEI UAM+CSIC, Madrid 28049, Spain; Department of Preventive 
      Medicine and Public Health, School of Medicine, Universidad Autonoma de Madrid, 
      Madrid, Spain; CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20221115
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Prospective Studies
MH  - Exercise
MH  - Risk
MH  - Proportional Hazards Models
MH  - Risk Factors
OTO - NOTNLM
OT  - Adults
OT  - Diabetes
OT  - Mortality
OT  - Physical activity
OT  - Prevention
COIS- Declaration of Competing Interest The authors have no relevant financial or 
      non-financial interests to disclose.
EDAT- 2022/11/19 06:00
MHDA- 2023/01/28 06:00
CRDT- 2022/11/18 19:37
PHST- 2022/01/23 00:00 [received]
PHST- 2022/10/21 00:00 [revised]
PHST- 2022/11/07 00:00 [accepted]
PHST- 2022/11/19 06:00 [pubmed]
PHST- 2023/01/28 06:00 [medline]
PHST- 2022/11/18 19:37 [entrez]
AID - S1262-3636(22)00091-X [pii]
AID - 10.1016/j.diabet.2022.101410 [doi]
PST - ppublish
SO  - Diabetes Metab. 2023 Jan;49(1):101410. doi: 10.1016/j.diabet.2022.101410. Epub 
      2022 Nov 15.