PMID- 36400571
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230314
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 200
IP  - 5
DP  - 2023 Mar
TI  - A comprehensive SEER registry analysis of elderly patients with classical Hodgkin 
      lymphoma based on treatment era and race.
PG  - 579-586
LID - 10.1111/bjh.18564 [doi]
AB  - We conducted a Surveillance, Epidemiology, and End Results Program (SEER-18) 
      registry analysis of classical Hodgkin lymphoma (cHL) patients more than 60 years 
      old and compared outcomes of those diagnosed between 2006 and 2010 (cohort 1) to 
      those identified between 2011 and 2015 (cohort 2) based on treatment era and 
      race. Cohort 1 had a median overall survival (OS) of 4 years and cohort 2 had a 
      median OS of 4.75 years [hazard ratio (HR): 0.92 (0.85-1.00); p = 0.052]. 
      Non-Hispanic blacks (NHBs) had a similar 5-year OS compared to non-Hispanic 
      whites (NHWs) of 48.6% vs. 50.2% (HR: 0.95 [0.79-1.15]; p > 0.99); on the 
      contrary, Hispanics had worse 5-year OS of 41.8% vs. 48.6% (HR: 1.24 [1.09-1.41]; 
      p < 0.001). NHW was the only race that had improvement in 5-year OS in 2011-2015 
      compared to 2006-2010 (51% vs. 46.5%, p = 0.002). In the multivariable analysis, 
      older age, male gender, stage III-IV, unmarried status, Hispanic race, lack of 
      chemotherapy, and diagnosis in 2006-2010 were associated with worse OS. Lymphoma 
      was the most common cause of death in 60% of patients. In conclusion, elderly cHL 
      patients diagnosed after 2010 had improved OS by nine months that was most 
      prevalent in NHWs, and disparity in OS existed between NHWs and Hispanics 
      throughout the study period.
CI  - (c) 2022 British Society for Haematology and John Wiley & Sons Ltd.
FAU - Shah, Harsh
AU  - Shah H
AUID- ORCID: 0000-0001-6054-5238
AD  - University of Utah/Huntsman Cancer Center, Salt Lake City, Utah, USA.
FAU - Jang, Hyejeong
AU  - Jang H
AD  - Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Detroit, 
      Michigan, USA.
AD  - Department of Oncology, School of Medicine, Wayne State University, Detroit, 
      Michigan, USA.
FAU - Kim, Seongho
AU  - Kim S
AD  - Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Detroit, 
      Michigan, USA.
AD  - Department of Oncology, School of Medicine, Wayne State University, Detroit, 
      Michigan, USA.
FAU - Halwani, Ahmad S
AU  - Halwani AS
AD  - Huntsman Cancer Institute, Salt Lake City, Utah, USA.
LA  - eng
PT  - Journal Article
DEP - 20221118
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Humans
MH  - Male
MH  - Aged
MH  - Middle Aged
MH  - *Hodgkin Disease/epidemiology/therapy
MH  - SEER Program
MH  - Registries
MH  - White People
MH  - Hispanic or Latino
OTO - NOTNLM
OT  - SEER
OT  - cHL
OT  - elderly
OT  - outcomes
EDAT- 2022/11/19 06:00
MHDA- 2023/02/22 06:00
CRDT- 2022/11/18 21:52
PHST- 2022/10/10 00:00 [revised]
PHST- 2022/07/31 00:00 [received]
PHST- 2022/11/02 00:00 [accepted]
PHST- 2022/11/19 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2022/11/18 21:52 [entrez]
AID - 10.1111/bjh.18564 [doi]
PST - ppublish
SO  - Br J Haematol. 2023 Mar;200(5):579-586. doi: 10.1111/bjh.18564. Epub 2022 Nov 18.