PMID- 36401011 OWN - NLM STAT- MEDLINE DCOM- 20230310 LR - 20230310 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 11 DP - 2023 Mar TI - Combined exposure to multiple dioxins and dioxin-like polychlorinated biphenyls on hypertension among US adults in NHANES: a cross-sectional study under three statistical models. PG - 28730-28744 LID - 10.1007/s11356-022-24271-3 [doi] AB - Dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs) are mainly released as by-products of human activities, often in the form of mixtures, and the potential harm on human health deserves attention. Therefore, our study aimed to analyze the combined effect of dioxins and DL-PCB exposures on hypertension (HTN) among US adults. Data of eligible participants were acquired from the National Health and Nutrition Examination Survey (NHANES). Multiple logistic regression models with adjustment for covariates were applied to explore the associations between 13 persistent organic pollutants (POPs) and HTN. Stratified analyses and interaction analyses were then conducted by age and gender. Finally, the combined effects of dioxins and DL-PCBs on HTN were assessed by the weighted quantile sum (WQS) model and the Bayesian kernel machine regression (BKMR) model. A total of 976 adults were included in our study, of whom 397 had HTN. Spearman correlations indicated positive correlations among 13 POPs. And most of them (except PCB28, PCB66, and 1,2,3,4,7,8,9-hpcdf) had significant effects on HTN. The result of WQS revealed that mixed exposure to dioxins and DL-PCBs was significantly associated with increased risk of HTN (OR: 2.205; 95% CIs: 1.555, 3.127). The BKMR model also presented a positive trend of HTN risk with exposure to multiple dioxins and DL-PCBs. And 1,2,3,4,6,7,8,9-ocdd may be the main factor for this positive association. Considering the limitations of our cross-sectional study with the small sample, further prospective studies are necessary to validate our findings. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Wu, Birong AU - Wu B AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Guo, Xianwei AU - Guo X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Feng, Linya AU - Feng L AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Gao, Juan AU - Gao J AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Xia, Weihang AU - Xia W AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Xie, Peng AU - Xie P AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Ma, Shaodi AU - Ma S AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Liu, Haixia AU - Liu H AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Zhao, Dongdong AU - Zhao D AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Qu, Guangbo AU - Qu G AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. AD - Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. FAU - Sun, Chenyu AU - Sun C AD - AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL, 60657, USA. FAU - Lowe, Scott AU - Lowe S AD - College of Osteopathic Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO, 64106, USA. FAU - Bentley, Rachel AU - Bentley R AD - College of Osteopathic Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO, 64106, USA. FAU - Sun, Yehuan AU - Sun Y AUID- ORCID: 0000-0002-8651-8059 AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. yhsun_ahmu_edu@yeah.net. AD - Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. yhsun_ahmu_edu@yeah.net. AD - Chaohu Hospital, Anhui Medical University, No. 64 Chaohubei Road, Hefei, 238006, Anhui, China. yhsun_ahmu_edu@yeah.net. LA - eng PT - Journal Article DEP - 20221118 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Dioxins) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Polychlorinated Dibenzodioxins) SB - IM MH - Adult MH - Humans MH - *Dioxins/analysis MH - *Polychlorinated Biphenyls/analysis MH - Nutrition Surveys MH - Cross-Sectional Studies MH - Prospective Studies MH - Bayes Theorem MH - *Polychlorinated Dibenzodioxins/analysis MH - Models, Statistical MH - *Hypertension/chemically induced/epidemiology OTO - NOTNLM OT - Bayesian kernel machine regression OT - Combined effects OT - Dioxin-like polychlorinated biphenyls OT - Dioxins OT - Hypertension OT - Weighted quantile sum EDAT- 2022/11/19 06:00 MHDA- 2023/03/11 06:00 CRDT- 2022/11/18 23:53 PHST- 2022/09/30 00:00 [received] PHST- 2022/11/14 00:00 [accepted] PHST- 2022/11/19 06:00 [pubmed] PHST- 2023/03/11 06:00 [medline] PHST- 2022/11/18 23:53 [entrez] AID - 10.1007/s11356-022-24271-3 [pii] AID - 10.1007/s11356-022-24271-3 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Mar;30(11):28730-28744. doi: 10.1007/s11356-022-24271-3. Epub 2022 Nov 18.