PMID- 36401380
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 46
DP  - 2022 Nov 18
TI  - Association of KCNJ11 and ABCC8 single-nucleotide polymorphisms with type 2 
      diabetes mellitus in a Kinh Vietnamese population.
PG  - e31653
LID - 10.1097/MD.0000000000031653 [doi]
LID - e31653
AB  - Type 2 diabetes mellitus (T2DM) is a genetically influenced disease, but few 
      studies have been performed to investigate the genetic basis of T2DM in 
      Vietnamese subjects. Thus, the potential associations of KCNJ11 and ABCC8 single 
      nucleotide polymorphisms (SNPs) with T2DM were investigated in a Kinh Vietnamese 
      population. A cross-sectional study consisting of 404 subjects including 202 T2DM 
      cases and 202 non-T2DM controls was designed to examine the potential 
      associations of 4 KCNJ11 and ABCC8 SNPs (rs5219, rs2285676, rs1799859, and 
      rs757110) with T2DM. Genotypes were identified based on restriction fragment 
      length polymorphism and tetra-primer amplification refractory mutation system 
      polymerase chain reaction. After statistically adjusting for age, sex, and BMI, 
      rs5219 was found to be associated with an increased risk of T2DM under 2 
      inheritance models: codominant (OR = 2.15, 95% confidence intervals 
      [CI] = 1.09-4.22) and recessive (OR = 2.08, 95%CI = 1.09-3.94). On the other 
      hand, rs2285676, rs1799859, and rs757110 were not associated with an increased 
      risk of T2DM. Haplotype analysis elucidated a strong linkage disequilibrium 
      between the 3 SNPs, rs5219, rs2285676, and rs757110. The haplotype 
      rs5219(A)/rs2285676(T)/rs757110(G) was associated with an increased risk of T2DM 
      (OR = 1.42, 95%CI = 1.01-1.99). The results show that rs5219 is a lead candidate 
      SNP associated with an increased risk of developing T2DM in the Kinh Vietnamese 
      population. Further functional characterization is needed to uncover the 
      mechanism underlying the potential genotype-phenotype associations.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Tran, Nam Quang
AU  - Tran NQ
AD  - Department of Endocrinology, Faculty of Medicine, University of Medicine and 
      Pharmacy at Ho Chi Minh City, Vietnam.
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Truong, Steven D
AU  - Truong SD
AD  - Department of Medicine, School of Medicine, Stanford University, USA.
FAU - Ma, Phat Tung
AU  - Ma PT
AD  - Department of Endocrinology, Faculty of Medicine, University of Medicine and 
      Pharmacy at Ho Chi Minh City, Vietnam.
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Hoang, Chi Khanh
AU  - Hoang CK
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Le, Bao Hoang
AU  - Le BH
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Dinh, Thang Tat Ngo
AU  - Dinh TTN
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Van Tran, Luong
AU  - Van Tran L
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Tran, Thang Viet
AU  - Tran TV
AD  - Department of Endocrinology, Faculty of Medicine, University of Medicine and 
      Pharmacy at Ho Chi Minh City, Vietnam.
AD  - Department of Endocrinology, University Medical Center, University of Medicine 
      and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Le, Linh Hoang Gia
AU  - Le LHG
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Vietnam.
FAU - Le, Khuong Thai
AU  - Le KT
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Vietnam.
FAU - Nguyen, Hien Thanh
AU  - Nguyen HT
AD  - Department of Medical Laboratory Technology, University of Medicine and Pharmacy 
      at Ho Chi Minh City, Vietnam.
FAU - Vu, Hoang Anh
AU  - Vu HA
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Vietnam.
FAU - Mai, Thao Phuong
AU  - Mai TP
AD  - Department of Physiology-Pathophysiology-Immunology, Faculty of Medicine, 
      University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
FAU - Do, Minh Duc
AU  - Do MD
AUID- ORCID: 0000-0002-9997-6390
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Vietnam.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 0 (ABCC8 protein, human)
RN  - 0 (Sulfonylurea Receptors)
SB  - IM
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Genetic Predisposition to Disease
MH  - Cross-Sectional Studies
MH  - *Potassium Channels, Inwardly Rectifying/genetics
MH  - Asian People/genetics
MH  - Sulfonylurea Receptors/genetics
PMC - PMC9678638
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2022/11/20 06:00
MHDA- 2022/11/23 06:00
PMCR- 2022/11/18
CRDT- 2022/11/19 01:04
PHST- 2022/11/19 01:04 [entrez]
PHST- 2022/11/20 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/11/18 00:00 [pmc-release]
AID - 00005792-202211180-00019 [pii]
AID - 10.1097/MD.0000000000031653 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2022 Nov 18;101(46):e31653. doi: 
      10.1097/MD.0000000000031653.