PMID- 36401693 OWN - NLM STAT- MEDLINE DCOM- 20230310 LR - 20230310 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 11 DP - 2023 Mar TI - Prenatal exposure to silver is associated with an elevated risk for neural tube defects: a case-control study. PG - 28925-28934 LID - 10.1007/s11356-022-24214-y [doi] AB - Exposure to copper, silver, and titanium has been reported to be associated with a variety of adverse effects on humans, but it is little focused on the fetus. We investigated the associations between prenatal exposure to the three metals (copper, silver, and titanium) and risk for fetal neural tube defects (NTDs). Placental samples from 408 women with pregnancies affected by NTDs and 593 women with normal pregnancies were collected from 2003 to 2016 in Pingding, Xiyang, Shouyang, Taigu, and Zezhou counties of China. Multilevel mixed-effects logistic regression and Bayesian kernel machine regression (BKMR) were used to evaluate the single and joint effects of the metals on NTDs. Silver was associated with an increased risk for NTDs in a dose-response fashion in single-metal logistic regression, with adjusted odds ratios (95% confidence intervals) of 1.78 (1.04-3.06) and 1.92 (1.11-3.32) in the second and third tertiles, respectively, compared to the lowest tertile. BKMR revealed toxic effects of silver on NTDs and the association appeared to be linear. No interaction of silver with any of the other two metals was observed. Besides, silver concentration was positively correlated with maternal certain dietary intakes. Placental high silver concentrations are associated with an elevated risk for NTDs. Maternal diet may be a source of silver exposure. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Pi, Xin AU - Pi X AD - Department of Social Medicine and Health Education, School of Public Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. FAU - Wang, Chengrong AU - Wang C AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Wang, Di AU - Wang D AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Yin, Shengju AU - Yin S AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. AD - Ministry of Education Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University, Shanghai, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Wang, Linlin AU - Wang L AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Yue, Wentao AU - Yue W AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Yin, Chenghong AU - Yin C AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Ren, Aiguo AU - Ren A AUID- ORCID: 0000-0001-9115-5638 AD - Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China. renag@bjmu.edu.cn. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. renag@bjmu.edu.cn. LA - eng GR - 2021YFC2701101/Ministry of Science and Technology of the People's Republic of China/ GR - 2021YFC2701001/Ministry of Science and Technology of the People's Republic of China/ PT - Journal Article DEP - 20221119 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 3M4G523W1G (Silver) RN - D1JT611TNE (Titanium) RN - 789U1901C5 (Copper) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Silver MH - Placenta MH - Titanium MH - Copper MH - Case-Control Studies MH - Bayes Theorem MH - *Prenatal Exposure Delayed Effects MH - *Neural Tube Defects/chemically induced/epidemiology MH - Maternal Exposure OTO - NOTNLM OT - Bayesian kernel machine regression OT - Copper OT - Neural tube defects OT - Silver OT - Titanium EDAT- 2022/11/20 06:00 MHDA- 2023/03/11 06:00 CRDT- 2022/11/19 11:16 PHST- 2022/07/04 00:00 [received] PHST- 2022/11/10 00:00 [accepted] PHST- 2022/11/20 06:00 [pubmed] PHST- 2023/03/11 06:00 [medline] PHST- 2022/11/19 11:16 [entrez] AID - 10.1007/s11356-022-24214-y [pii] AID - 10.1007/s11356-022-24214-y [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Mar;30(11):28925-28934. doi: 10.1007/s11356-022-24214-y. Epub 2022 Nov 19.