PMID- 36402703
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20221226
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 31
IP  - 12
DP  - 2022 Dec
TI  - Influence of Iron Deficiency on Clinical and Haemodynamic Parameters in Pulmonary 
      Arterial Hypertension Cohorts.
PG  - 1594-1603
LID - S1443-9506(22)01094-0 [pii]
LID - 10.1016/j.hlc.2022.09.001 [doi]
AB  - BACKGROUND: Iron deficiency (Fe(def)) has been shown to be common in patients 
      with group 1 or pulmonary arterial hypertension (PAH). Several studies have shown 
      a negative impact of Fe(def) on clinical and haemodynamic parameters of the 
      disease, but data from individual studies have not been strong enough to lead to 
      incorporation of the finding of Fe(def) into prognostic or therapeutic 
      algorithms. The goal of this meta-analysis was to combine data from available 
      studies to better define any associations between Fe(def) and established 
      variables of prognostic importance in PAH. METHODS: A literature search 
      identified nine studies with extractable data relevant to the study questions. 
      The impact of Fe(def) upon the following parameters was evaluated: 6-minute walk 
      distance (6MWD), WHO-functional class, N-terminal pro-brain natriuretic peptide 
      (NT-proBNP) levels, echocardiography, and findings from right heart 
      catheterisation (RHC). Pooled results were reported as mean difference or risk 
      difference with 95% confidence intervals utilising a random effects modeling 
      approach. RESULTS: Fe(def) in the PAH population was common (47% of cases) and 
      was associated with cardiovascular dysfunction (lower tricuspid annular plane 
      systolic excursion [TAPSE], elevated NT-proBNP, and lower mixed venous oxygen 
      saturation) and with reduction in functional capacity (lower 6MWD and higher 
      functional class). CONCLUSION: This meta-analysis strengthens the relationships 
      between Fe(def) and several markers of poor outcome in PAH. Fe(def) in patients 
      with PAH warrants further scrutiny and merits consideration as a cause of 
      clinical deterioration. Even though causation and longitudinal relationships 
      between Fe(def) and PAH could not be identified, effect of Fe(def) on factors 
      that affect disease prognosis is noteworthy and worthy of more focussed studies.
CI  - Copyright (c) 2022 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Saluja, Prachi
AU  - Saluja P
AD  - Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, 
      AR, USA. Electronic address: http://www.twitter.com/prachisaluja8.
FAU - Gautam, Nitesh
AU  - Gautam N
AD  - Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, 
      AR, USA.
FAU - Amisha, Fnu
AU  - Amisha F
AD  - Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, 
      AR, USA.
FAU - Salah, Husam M
AU  - Salah HM
AD  - Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, 
      AR, USA.
FAU - Smith, Jake
AU  - Smith J
AD  - Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, 
      AR, USA.
FAU - Biyani, Shubham
AU  - Biyani S
AD  - Department of Neurology, University of Arkansas for Medical Sciences, Little 
      Rock, AR, USA.
FAU - Venkata, Anand N
AU  - Venkata AN
AD  - Division of Pulmonary and Critical Care Medicine, Department of Medicine, 
      University of Arkansas for Medical Sciences, Little Rock, AR, USA.
FAU - Al'Aref, Subhi J
AU  - Al'Aref SJ
AD  - Division of Cardiology, Department of Medicine, University of Arkansas for 
      Medical Sciences, Little Rock, AR, USA.
FAU - Jagana, Rajani
AU  - Jagana R
AD  - Division of Pulmonary and Critical Care Medicine, Department of Medicine, 
      University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic 
      address: RJagana@uams.edu.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20221116
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Humans
MH  - *Pulmonary Arterial Hypertension/etiology
MH  - *Hypertension, Pulmonary/diagnosis/etiology/drug therapy
MH  - Familial Primary Pulmonary Hypertension
MH  - Hemodynamics
MH  - Natriuretic Peptide, Brain
MH  - Peptide Fragments
MH  - *Iron Deficiencies
OTO - NOTNLM
OT  - BNP levels
OT  - Echocardiography
OT  - Iron deficiency
OT  - Pulmonary arterial hypertension
OT  - Six-minute walk test
OT  - WHO/NYHA functional class
EDAT- 2022/11/20 06:00
MHDA- 2022/12/27 06:00
CRDT- 2022/11/19 22:06
PHST- 2022/03/10 00:00 [received]
PHST- 2022/08/16 00:00 [revised]
PHST- 2022/09/01 00:00 [accepted]
PHST- 2022/11/20 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/11/19 22:06 [entrez]
AID - S1443-9506(22)01094-0 [pii]
AID - 10.1016/j.hlc.2022.09.001 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2022 Dec;31(12):1594-1603. doi: 10.1016/j.hlc.2022.09.001. Epub 
      2022 Nov 16.