PMID- 36402910
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20230110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Nov 19
TI  - Persistent organic pollutant exposure contributes to Black/White differences in 
      leukocyte telomere length in the National Health and Nutrition Examination 
      Survey.
PG  - 19960
LID - 10.1038/s41598-022-24316-0 [doi]
LID - 19960
AB  - Despite racial disparities in diseases of aging and premature mortality, 
      non-Hispanic Black Americans tend to have longer leukocyte telomere length (LTL), 
      a biomarker of cellular aging, than non-Hispanic White Americans. Previous 
      findings suggest that exposure to certain persistent organic pollutants (POPs) is 
      both racially-patterned and associated with longer LTL. We examine whether 
      Black/White differences in LTL are explained by differences in exposure to 15 
      POPs by estimating the indirect effect (IE) of self-reported race on LTL that is 
      mediated through nine polychlorinated biphenyls (PCBs), three furans, and three 
      dioxins, as well as their mixtures. Our study population includes 1,251 adults 
      from the 1999-2000 and 2001-2002 cycles of the cross-sectional National Health 
      and Nutrition Examination Survey. We characterized single-pollutant mediation 
      effects by constructing survey-weighted linear regression models. We also 
      implemented various approaches to quantify a global mediation effect of all POPs, 
      including unpenalized linear regression, ridge regression, and examination of 
      three summary exposure scores. We found support for the hypothesis that exposure 
      to PCBs partially mediates Black/White differences in LTL. In single-pollutant 
      models, there were significant IEs of race on LTL through six individual PCBs 
      (118, 138, 153, 170, 180, and 187). Ridge regression (0.013, CI 0.001, 0.023; 
      26.0% mediated) and models examining summative exposure scores with linear 
      combinations derived from principal components analysis (0.019, CI 0.009, 0.029; 
      34.8% mediated) and Toxic Equivalency Quotient (TEQ) scores (0.016, CI 0.005, 
      0.026; 28.8% mediated) showed significant IEs when incorporating survey weights. 
      Exposures to individual POPs and their mixtures, which may arise from residential 
      and occupational segregation, may help explain why Black Americans have longer 
      LTL than their White counterparts, providing an environmental explanation for 
      counterintuitive race differences in cellular aging.
CI  - (c) 2022. The Author(s).
FAU - Roberts, Emily K
AU  - Roberts EK
AD  - Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109-2029, 
      USA.
FAU - Boss, Jonathan
AU  - Boss J
AD  - Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109-2029, 
      USA.
FAU - Mukherjee, Bhramar
AU  - Mukherjee B
AD  - Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109-2029, 
      USA.
AD  - Department of Epidemiology and Center for Social Epidemiology and Population 
      Health, University of Michigan, 1415 Washington Heights, 4659 SPH Tower, Ann 
      Arbor, MI, 48109-2029, USA.
FAU - Salerno, Stephen
AU  - Salerno S
AD  - Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109-2029, 
      USA.
FAU - Zota, Ami
AU  - Zota A
AD  - Department of Environmental and Occupational Health, George Washington University 
      Milken School of Public Health, Washington, USA.
AD  - Department of Environmental Health Sciences, Columbia University Mailman School 
      of Public Health, New York, USA.
FAU - Needham, Belinda L
AU  - Needham BL
AD  - Department of Epidemiology and Center for Social Epidemiology and Population 
      Health, University of Michigan, 1415 Washington Heights, 4659 SPH Tower, Ann 
      Arbor, MI, 48109-2029, USA. needhamb@umich.edu.
LA  - eng
GR  - R01 AG033592/AG/NIA NIH HHS/United States
GR  - U24 AG066528/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20221119
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Persistent Organic Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - White People
MH  - Leukocytes
MH  - *Environmental Pollutants/toxicity
MH  - Telomere/genetics
PMC - PMC9675834
COIS- The authors declare no competing interests.
EDAT- 2022/11/20 06:00
MHDA- 2022/11/23 06:00
PMCR- 2022/11/19
CRDT- 2022/11/19 23:47
PHST- 2022/06/22 00:00 [received]
PHST- 2022/11/14 00:00 [accepted]
PHST- 2022/11/19 23:47 [entrez]
PHST- 2022/11/20 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/11/19 00:00 [pmc-release]
AID - 10.1038/s41598-022-24316-0 [pii]
AID - 24316 [pii]
AID - 10.1038/s41598-022-24316-0 [doi]
PST - epublish
SO  - Sci Rep. 2022 Nov 19;12(1):19960. doi: 10.1038/s41598-022-24316-0.