PMID- 36403041
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221123
IS  - 1749-799X (Electronic)
IS  - 1749-799X (Linking)
VI  - 17
IP  - 1
DP  - 2022 Nov 19
TI  - Efficacy and safety of platelet-rich plasma combined with hyaluronic acid versus 
      platelet-rich plasma alone for knee osteoarthritis: a systematic review and 
      meta-analysis.
PG  - 499
LID - 10.1186/s13018-022-03398-6 [doi]
LID - 499
AB  - PURPOSE: To systematically evaluate the curative efficacy and safety of 
      platelet-rich plasma (PRP) combined with hyaluronic acid (HA) in the treatment of 
      knee osteoarthritis (KOA), comparing with platelet-rich plasma alone. METHODS: 
      Cochrane Library, PubMed, China National Knowledge Infrastructure (CNKI) and 
      Embase were searched for randomized controlled trials (RCTs) and cohort studies 
      regarding the efficacy and safety of platelet-rich plasma (PRP) combined with 
      hyaluronic acid (HA) in the treatment of knee osteoarthritis (KOA) comparing with 
      platelet-rich plasma alone before January 15, 2022. The methodological quality of 
      the ultimately included studies was assessed comprehensively, and meta-analysis 
      was implemented using RevMan 5.3 software. RESULTS: Thirteen articles (9 RCTs, 4 
      cohort studies), including 1118 patients, were covered. There was no significant 
      difference between the PRP + HA therapy and PRP-alone therapy in VAS scores at 3 
      months, 6 months and 12 months, WOMAC total scores at 3 months and KOOS at 1 
      month and 6 months. Compared with PRP-alone therapy, PRP + HA therapy was 
      associated with significantly better improvement in VAS scores at 1 month, WOMAC 
      total scores at 6 months, KOOS at 3 months, IKDC scores at 6 months and Lequesne 
      index scores at 3 and 6 months. However, the smallest treatment effect of VAS 
      scores, WOMAC total scores, KOOS and IKDC scores did not exceed the minimum 
      clinically important difference (MCID). However, PRP + HA therapy got a greater 
      reduction in the rate of adverse events, compared with PRP-alone therapy. 
      CONCLUSION: The results of this meta-analysis indicated that PRP + HA therapy was 
      not found to be superior to PRP-alone therapy in pain relief and function 
      improvement for patients with KOA. However, combined PRP with HA injections was 
      generally safer than PRP injections alone, by assessing the incidence of adverse 
      events.
CI  - (c) 2022. The Author(s).
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Orthopaedics, The Second Xiangya Hospital, Central South 
      University, No. 139 Renmin Street, Changsha, 410000, Hunan, People's Republic of 
      China.
FAU - Liu, Tuodong
AU  - Liu T
AD  - Department of Orthopaedics, The Second Xiangya Hospital, Central South 
      University, No. 139 Renmin Street, Changsha, 410000, Hunan, People's Republic of 
      China.
FAU - Gu, Yuan
AU  - Gu Y
AD  - Department of Orthopaedics, The Second Xiangya Hospital, Central South 
      University, No. 139 Renmin Street, Changsha, 410000, Hunan, People's Republic of 
      China.
FAU - Gao, Yongquan
AU  - Gao Y
AD  - Department of Orthopaedics, The Second Xiangya Hospital, Central South 
      University, No. 139 Renmin Street, Changsha, 410000, Hunan, People's Republic of 
      China.
FAU - Ni, Jiangdong
AU  - Ni J
AD  - Department of Orthopaedics, The Second Xiangya Hospital, Central South 
      University, No. 139 Renmin Street, Changsha, 410000, Hunan, People's Republic of 
      China. nijiangdong001@csu.edu.cn.
LA  - eng
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20221119
PL  - England
TA  - J Orthop Surg Res
JT  - Journal of orthopaedic surgery and research
JID - 101265112
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Humans
MH  - Hyaluronic Acid/therapeutic use
MH  - *Osteoarthritis, Knee/therapy
MH  - Injections, Intra-Articular
MH  - *Platelet-Rich Plasma
MH  - Minimal Clinically Important Difference
PMC - PMC9675184
OTO - NOTNLM
OT  - Hyaluronic acid
OT  - Knee osteoarthritis
OT  - Meta-analysis
OT  - Platelet-rich plasma
COIS- The authors declare that they have no competing interests.
EDAT- 2022/11/20 06:00
MHDA- 2022/11/23 06:00
PMCR- 2022/11/19
CRDT- 2022/11/19 23:58
PHST- 2022/04/05 00:00 [received]
PHST- 2022/11/10 00:00 [accepted]
PHST- 2022/11/19 23:58 [entrez]
PHST- 2022/11/20 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/11/19 00:00 [pmc-release]
AID - 10.1186/s13018-022-03398-6 [pii]
AID - 3398 [pii]
AID - 10.1186/s13018-022-03398-6 [doi]
PST - epublish
SO  - J Orthop Surg Res. 2022 Nov 19;17(1):499. doi: 10.1186/s13018-022-03398-6.