PMID- 36403383
OWN - NLM
STAT- MEDLINE
DCOM- 20230109
LR  - 20230111
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 164
DP  - 2023 Jan
TI  - Long-term effects of submandibular gland excision on drooling in children with 
      neurodevelopmental disorders: A cross-sectional study.
PG  - 111377
LID - S0165-5876(22)00338-X [pii]
LID - 10.1016/j.ijporl.2022.111377 [doi]
AB  - AIM: Submandibular gland excision (SMGE) is suitable for the management of 
      drooling in patients with non-progressive neurodisabilities. We aimed to 
      investigate the long-term effects of SMGE. METHOD: Patients who had SMGE between 
      2007 and 2018 were included. Main outcomes were a Visual Analogue Scale (VAS), 
      Drooling Severity (DS), and Drooling Frequency (DF) collected at baseline, 8 
      weeks, 32 weeks and with a median of 313 weeks after SMGE (long-term). Secondary 
      outcomes were satisfaction with the procedure, Drooling Quotient (DQ) and adverse 
      events (AEs). RESULTS: We included thirty-five patients in the long-term analysis 
      with a mean age of 14.5 years. A baseline VAS score of 80.4 was found, which 
      improved on the long-term (mean difference -21.8, t(26) = 4.636, p < 0.0005)). DS 
      and DF decreased significantly at the long-term compared to baseline (Z = -4.361, 
      p < 0.0001 for DS, Z = -3.065, p = 0.002 for DF). Twenty-three out of 35 (66%) 
      patients would recommend the procedure to peers. INTERPRETATION: This study 
      indicates a long-term stable effect on drooling after SMGE in patients with 
      anterior drooling. Recurrence of drooling occurs due to unknown reasons, 
      nevertheless most caregivers and/or patients are still satisfied and would 
      recommend the procedure to others.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Delsing, Corinne P A
AU  - Delsing CPA
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Centre, Philips Van Leijdenlaan 15 (route 377), Postbus 9101, Nijmegen, 
      6500 HB, the Netherlands. Electronic address: Corinne.Delsing@radboudumc.nl.
FAU - Adriaansens, Carleen
AU  - Adriaansens C
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Centre, Philips Van Leijdenlaan 15 (route 377), Postbus 9101, Nijmegen, 
      6500 HB, the Netherlands.
FAU - van Hulst, Karen
AU  - van Hulst K
AD  - Department of Rehabilitation, Donders Institute for Brain, Cognition and 
      Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
FAU - Erasmus, Corrie E
AU  - Erasmus CE
AD  - Department of Pediatric Neurology, Donders Institute for Brain, Cognition and 
      Behaviour, Radboud University Medical Center, Amalia Children's Hospital, 
      Nijmegen, the Netherlands.
FAU - van den Hoogen, Frank J A
AU  - van den Hoogen FJA
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Centre, Philips Van Leijdenlaan 15 (route 377), Postbus 9101, Nijmegen, 
      6500 HB, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20221111
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
SB  - IM
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - *Sialorrhea/surgery/complications
MH  - Cross-Sectional Studies
MH  - Submandibular Gland/surgery
MH  - Salivary Glands
MH  - *Neurodevelopmental Disorders
MH  - Treatment Outcome
MH  - *Cerebral Palsy/complications
EDAT- 2022/11/21 06:00
MHDA- 2023/01/10 06:00
CRDT- 2022/11/20 18:13
PHST- 2022/09/09 00:00 [received]
PHST- 2022/10/31 00:00 [revised]
PHST- 2022/11/04 00:00 [accepted]
PHST- 2022/11/21 06:00 [pubmed]
PHST- 2023/01/10 06:00 [medline]
PHST- 2022/11/20 18:13 [entrez]
AID - S0165-5876(22)00338-X [pii]
AID - 10.1016/j.ijporl.2022.111377 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2023 Jan;164:111377. doi: 
      10.1016/j.ijporl.2022.111377. Epub 2022 Nov 11.