PMID- 36403740
OWN - NLM
STAT- MEDLINE
DCOM- 20221201
LR  - 20221201
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 302
IP  - Pt B
DP  - 2023 Feb 10
TI  - ZiBuPiYin recipe ameliorates diabetes-associated cognitive decline by improving 
      neuronal mitochondrial function in chronic psychologically stressed zucker 
      diabetic fatty rats.
PG  - 115947
LID - S0378-8741(22)00986-2 [pii]
LID - 10.1016/j.jep.2022.115947 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Zibu Piyin Recipe (ZBPYR) is a traditional 
      Chinese medicine compound composed of 12 kinds of Chinese herbal medicines 
      including red ginseng and yam. Long-term basic and clinical applications have 
      proved that ZBPYR can prevent and treat cognitive dysfunction. Previous studies 
      showed that chronic psychological stress can increase the risk of type 2 diabetes 
      mellitus (T2DM), and lead to cognitive decline. Mitochondrial dysfunction plays a 
      key role in chronic psychological stress-induced diabetes mellitus. While the 
      mechanism of mitochondrial dysfunction and insulin resistance in 
      diabetes-associated cognitive decline (DACD) is unclear. AIM OF THE STUDY: Our 
      previous research found that a ZiBuPiYin recipe (ZBPYR) has significant 
      pharmacological effects against DACD. The present study investigated changes in 
      mitochondrial dysfunction in the brain and the mechanism of insulin resistance 
      and mitochondrial damage to explore the relationship between neuronal 
      mitochondrial dysfunction and insulin resistance in chronic psychologically 
      stressed DACD rats. MATERIALS AND METHODS: Zucker diabetic fatty (ZDF) rats with 
      spontaneous T2DM and rats with diabetic cognitive impairment that was induced by 
      chronic psychological stress were used in in vivo experiments. PC12 cells that 
      were damaged by rotenone were used for the in vitro experiment. RESULTS: The 
      findings indicated that the number of mitochondria decreased, morphology and 
      membrane potential were damaged, and reactive oxygen species increased in the 
      cortex and hippocampus in psychologically stressed DACD rats. Protein kinase Cbeta2 
      (PKCbeta2) activation and insulin resistance were markedly induced by chronic 
      psychological stress, together with decreases in peroxisome 
      proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) and mitochondrial 
      fusion protein 2 (Mfn2). Furthermore, ZBPYR exerted protective effects both in in 
      vivo and in vitro. CONCLUSION: Mitochondrial damage and insulin resistance were 
      observed in the brain in chronic psychologically stressed DACD rats. The ZBPYR 
      significantly improved brain mitochondrial damage and insulin resistance in 
      chronic psychologically stressed DACD rats. These results provide novel insights 
      for the development of ZBPYR as a traditional Chinese medicine for the treatment 
      of chronic psychological stress and DACD.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Sui, Hua
AU  - Sui H
AD  - Institute of Integrative Medicine, Dalian Medical University, Dalian, 116044, 
      Liaoning, China. Electronic address: dianasuihua@163.com.
FAU - Zhu, Lianlian
AU  - Zhu L
AD  - Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, Liaoning, 
      China. Electronic address: lianlianzhu1991@126.com.
FAU - Zhan, Libin
AU  - Zhan L
AD  - Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, Liaoning, 
      China. Electronic address: zlblibin2021@163.com.
FAU - Bi, Tingting
AU  - Bi T
AD  - School of Traditional Chinese Medicine & School of Integrated Chinese and Western 
      Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, 
      China. Electronic address: beetingting@163.com.
FAU - Zhang, Boyu
AU  - Zhang B
AD  - Institute of Integrative Medicine, Dalian Medical University, Dalian, 116044, 
      Liaoning, China. Electronic address: 827715109@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20221117
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Mitochondrial Proteins)
SB  - IM
MH  - Animals
MH  - Rats
MH  - Rats, Zucker
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - *Cognitive Dysfunction/drug therapy/etiology
MH  - Mitochondria
MH  - Mitochondrial Proteins
OTO - NOTNLM
OT  - Chronic psychological stress
OT  - Cognitive decline
OT  - Diabetes
OT  - Mitochondrial
OT  - ZiBuPiYin recipe
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/21 06:00
MHDA- 2022/12/02 06:00
CRDT- 2022/11/20 19:25
PHST- 2022/07/24 00:00 [received]
PHST- 2022/10/13 00:00 [revised]
PHST- 2022/11/13 00:00 [accepted]
PHST- 2022/11/21 06:00 [pubmed]
PHST- 2022/12/02 06:00 [medline]
PHST- 2022/11/20 19:25 [entrez]
AID - S0378-8741(22)00986-2 [pii]
AID - 10.1016/j.jep.2022.115947 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2023 Feb 10;302(Pt B):115947. doi: 10.1016/j.jep.2022.115947. 
      Epub 2022 Nov 17.