PMID- 36404328
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221213
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Nov 20
TI  - Neutrophilic granulocyte percentage is associated with anxiety in Chinese 
      hospitalized heart failure patients.
PG  - 494
LID - 10.1186/s12872-022-02940-y [doi]
LID - 494
AB  - BACKGROUND: In patients with heart failure, anxiety disorder is common and 
      associated with adverse prognosis. This study intended to find more confounding 
      factors of Chinese heart failure patients. METHODS: We enrolled 284 hospitalized 
      heart failure patients, whose New York Heart Association (NYHA) classed as II-IV 
      and left ventricular ejection fraction (LVEF) </= 45%. All the patients were scaled 
      in Hamilton Rating Scale for Anxiety (14-items) (HAM-A14). Ordinal logistic 
      regression analysis was performed to examine the association of correlated 
      factors with anxiety disorder. RESULTS: There were 184 patients had anxiety 
      accounting for 64.8% of all 284 hospitalized heart failure patients. The 
      neutrophilic granulocyte percentage, urea nitrogen, total bilirubin and brain 
      natriuretic peptide were positively associated with HAM-A14 score, meanwhile, the 
      hemoglobin, red blood cells counts, albumin and LVEF were negatively associated 
      with HAM-A14 score (All P < 0.05). After the adjustments of sex, hemoglobin, urea 
      nitrogen, total bilirubin, albumin and brain natriuretic peptide, the 
      neutrophilic granulocyte percentage was significantly associated with anxiety 
      (OR = 43.265, P = 0.012). The neutrophilic granulocyte percentage was 
      0.616 +/- 0.111, 0.640 +/- 0.102, 0.681 +/- 0.106 and 0.683 +/- 0.113 in heart failure 
      patients with no anxiety, possible anxiety, confirmed anxiety and obvious 
      anxiety, respectively. CONCLUSIONS: Neutrophilic granulocyte percentage as well 
      as the traditional risk factors such as sex, urea nitrogen and brain natriuretic 
      peptide is associated with anxiety in hospitalized heart failure patients.
CI  - (c) 2022. The Author(s).
FAU - Ma, Qian
AU  - Ma Q
AD  - First Department of Cardiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, People's Republic of China.
FAU - Zhang, Feng-Bo
AU  - Zhang FB
AD  - The Clinical Laboratory Medical Center, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang, People's Republic of China.
FAU - Yao, En-Sheng
AU  - Yao ES
AD  - Department of Neurology, First Affiliated Hospital, School of Medicine, Shihezi 
      University, Shihezi, Xinjiang, People's Republic of China.
FAU - Pan, Shuo
AU  - Pan S
AD  - Cardiovascular Department, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, 
      People's Republic of China. parker1985@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221120
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - RFM9X3LJ49 (Bilirubin)
RN  - 0 (Albumins)
RN  - N762921K75 (Nitrogen)
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Humans
MH  - *Natriuretic Peptide, Brain
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - *Heart Failure/diagnosis
MH  - Anxiety Disorders
MH  - Granulocytes/chemistry
MH  - Bilirubin
MH  - Albumins/analysis
MH  - Nitrogen/analysis
MH  - China/epidemiology
MH  - Urea
PMC - PMC9677905
OTO - NOTNLM
OT  - Anxiety
OT  - Chinese
OT  - Hospitalized heart failure
OT  - Neutrophilic granulocyte percentage
COIS- The authors declare that they have no competing interests.
EDAT- 2022/11/21 06:00
MHDA- 2022/11/23 06:00
PMCR- 2022/11/20
CRDT- 2022/11/20 23:16
PHST- 2022/08/14 00:00 [received]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/11/20 23:16 [entrez]
PHST- 2022/11/21 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/11/20 00:00 [pmc-release]
AID - 10.1186/s12872-022-02940-y [pii]
AID - 2940 [pii]
AID - 10.1186/s12872-022-02940-y [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2022 Nov 20;22(1):494. doi: 10.1186/s12872-022-02940-y.