PMID- 36405254
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221122
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 32
DP  - 2022 Nov 16
TI  - t(4;11) translocation in hyperdiploid de novo adult acute myeloid leukemia: A 
      case report.
PG  - 11980-11986
LID - 10.12998/wjcc.v10.i32.11980 [doi]
AB  - BACKGROUND: MLL gene rearrangement is a common genetic abnormality of acute 
      myeloid leukemia (AML), which predicts poor prognosis and is important in 
      clinical diagnosis. MLL rearrangement involves many chromosomes, among which, 
      t(4;11) translocation is rare in AML. The present case was t(4;11) AML, 
      accompanied by a hyperdiploid karyotype. Such cases have not been reported 
      previously. CASE SUMMARY: An adult male with self-reported symptoms of fatigue, 
      febrility and hyperleukocytosis was diagnosed with AML by morphology and 
      confirmed by immunophenotype analysis. Uncommonly, chromosomal and fluorescence 
      in situ hybridization (FISH) analysis showed a hyperdiploid karyotype with 
      t(4;11) translocation and MLL rearrangement, and a negative MLL-AF4 fusion gene 
      result. The patient died of respiratory and circulatory failure 5 days after 
      diagnosis. CONCLUSION: t(4;11) AML with hyperdiploid karyotype has not been 
      reported. In this case, t(4;11) was only detected by karyotype analysis and FISH, 
      suggesting their importance in MLL rearrangement detection.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Zhang, Min-Yu
AU  - Zhang MY
AD  - Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang 
      110022, Liaoning Province, China.
FAU - Zhao, Yue
AU  - Zhao Y
AD  - Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang 
      110022, Liaoning Province, China.
FAU - Zhang, Ji-Hong
AU  - Zhang JH
AD  - Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang 
      110022, Liaoning Province, China. zhangjh96615@126.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC9669862
OTO - NOTNLM
OT  - 11)
OT  - Acute myeloid leukemia
OT  - Case report
OT  - FISH
OT  - Hyperdiploid
OT  - MLL gene rearrangement
OT  - Translocation t(4
COIS- Conflict-of-interest statement: All authors disclosed no conflict of interest.
EDAT- 2022/11/22 06:00
MHDA- 2022/11/22 06:01
PMCR- 2022/11/16
CRDT- 2022/11/21 03:53
PHST- 2022/08/30 00:00 [received]
PHST- 2022/09/23 00:00 [revised]
PHST- 2022/10/20 00:00 [accepted]
PHST- 2022/11/21 03:53 [entrez]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2022/11/22 06:01 [medline]
PHST- 2022/11/16 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i32.11980 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Nov 16;10(32):11980-11986. doi: 
      10.12998/wjcc.v10.i32.11980.