PMID- 36405453
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221122
IS  - 1809-9777 (Print)
IS  - 1809-4864 (Electronic)
IS  - 1809-4864 (Linking)
VI  - 26
IP  - 4
DP  - 2022 Oct
TI  - The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell 
      Motility in Rat Offspring.
PG  - e712-e717
LID - 10.1055/s-0042-1745856 [doi]
AB  - Introduction  Perinatal hypothyroidism has a negative repercussion on the 
      development and maturation of auditory system function. However, its long-term 
      effect on auditory function remains unsettled. Objective  To evaluate the effect 
      of prenatal hypothyroidism on the auditory function of adult offspring in rats. 
      Methods  Pregnant Wistar rats were given the antithyroid drug methimazole (0.02% 
      -1-methylimidazole-2-thiol- MMI) in drinking water, ad libitum, from gestational 
      day (GD) 9 to postnatal day 15 (PND15). Anesthetized offspring from MMI-treated 
      dams (OMTD) and control rats were evaluated by tympanometry, distortion product 
      otoacoustic emission (DPOAE), and auditory brainstem response (ABR) at PNDs 30, 
      60, 90, and 120. Results  Our data demonstrated no middle ear dysfunction, with 
      the OMTD compliance lower than that of the control group. The DPOAE revealed the 
      absence of outer hair cells function, and the ABR showed normal integrity of 
      neural auditory pathways up to brainstem level in the central nervous system. 
      Furthermore, in the OMTD group, hearing loss was characterized by a higher 
      electrophysiological threshold. Conclusion  Our data suggest that perinatal 
      hypothyroidism leads to irreversible damage to cochlear function in offspring.
CI  - Fundacao Otorrinolaringologia. This is an open access article published by Thieme 
      under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial 
      License, permitting copying and reproduction so long as the original work is 
      given appropriate credit. Contents may not be used for commecial purposes, or 
      adapted, remixed, transformed or built upon. ( 
      https://creativecommons.org/licenses/by-nc-nd/4.0/ ).
FAU - Oliveira, Priscila Feliciano de
AU  - Oliveira PF
AUID- ORCID: 0000-0002-6443-6167
AD  - Department of Health Sciences, Universidade Federal de Sergipe, Sao Cristovao, 
      SE, Brazil.
AD  - Department of Speech, Language and Hearing, Universidade Federal de Sergipe, Sao 
      Cristovao, SE, Brazil.
AD  - Department of Physiology, Universidade Federal de Sergipe, Sao Cristovao, SE, 
      Brazil.
FAU - Trindade, Beatriz Barros Santos
AU  - Trindade BBS
AUID- ORCID: 0000-0003-4171-7529
AD  - Department of Speech, Language and Hearing, Universidade Federal de Sergipe, Sao 
      Cristovao, SE, Brazil.
FAU - Reis, Paloma Fonseca Martins
AU  - Reis PFM
AUID- ORCID: 0000-0002-8789-7222
AD  - Department of Speech, Language and Hearing, Universidade Federal de Sergipe, Sao 
      Cristovao, SE, Brazil.
FAU - Santos, Tamara Figueiredo do Carmo
AU  - Santos TFDC
AUID- ORCID: 0000-0003-4824-842X
AD  - Department of Speech, Language and Hearing, Universidade Federal de Sergipe, Sao 
      Cristovao, SE, Brazil.
FAU - Alves, Julio Cesar Santana
AU  - Alves JCS
AUID- ORCID: 0000-0002-6516-3463
AD  - Department of Health Sciences, Universidade Federal de Sergipe, Sao Cristovao, 
      SE, Brazil.
AD  - Department of Veterinary Medicine, Faculdade Pio Decimo , Aracaju, SE, Brazil.
AD  - Department of Physiology, Universidade Federal de Sergipe, Sao Cristovao, SE, 
      Brazil.
FAU - Santana, Demetrius Silva de
AU  - Santana DS
AUID- ORCID: 0000-0002-6216-5770
AD  - Department of Physiology, Universidade Federal de Sergipe, Sao Cristovao, SE, 
      Brazil.
AD  - Department of Science Computation, Universidade Federal de Sergipe, Sao 
      Cristovao, SE, Brazil.
FAU - Badaue-Passos, Daniel Jr
AU  - Badaue-Passos D Jr
AUID- ORCID: 0000-0002-7600-0280
AD  - Department of Physiology, Universidade Federal de Sergipe, Sao Cristovao, SE, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220614
PL  - Brazil
TA  - Int Arch Otorhinolaryngol
JT  - International archives of otorhinolaryngology
JID - 101637652
PMC - PMC9668424
OTO - NOTNLM
OT  - cochlea
OT  - congenital hypothyroidism
OT  - hearing loss
COIS- Conflict of Interests The authors declare that there is no conflict of interests.
EDAT- 2022/11/22 06:00
MHDA- 2022/11/22 06:01
PMCR- 2022/06/01
CRDT- 2022/11/21 03:57
PHST- 2021/09/28 00:00 [received]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/11/21 03:57 [entrez]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2022/11/22 06:01 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 210697 [pii]
AID - 10.1055/s-0042-1745856 [doi]
PST - epublish
SO  - Int Arch Otorhinolaryngol. 2022 Jun 14;26(4):e712-e717. doi: 
      10.1055/s-0042-1745856. eCollection 2022 Oct.