PMID- 36406126
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221122
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 13
DP  - 2022
TI  - A comparative analysis of telomere length maintenance circuits in fission and 
      budding yeast.
PG  - 1033113
LID - 10.3389/fgene.2022.1033113 [doi]
LID - 1033113
AB  - The natural ends of the linear eukaryotic chromosomes are protected by telomeres, 
      which also play an important role in aging and cancer development. Telomere 
      length varies between species, but it is strictly controlled in all organisms. 
      The process of Telomere Length Maintenance (TLM) involves many pathways, protein 
      complexes and interactions that were first discovered in budding and fission 
      yeast model organisms (Saccharomyces cerevisiae, Schizosaccharomyces pombe). In 
      particular, large-scale systematic genetic screens in budding yeast uncovered a 
      network of   approximately   500 genes that, when mutated, cause telomeres to lengthen or to 
      shorten. In contrast, the TLM network in fission yeast remains largely unknown 
      and systematic data is still lacking. In this work we try to close this gap and 
      develop a unified interpretable machine learning framework for TLM gene discovery 
      and phenotype prediction in both species. We demonstrate the utility of our 
      framework in pinpointing the pathways by which TLM homeostasis is maintained and 
      predicting novel TLM genes in fission yeast. The results of this study could be 
      used for better understanding of telomere biology and serve as a step towards the 
      adaptation of computational methods based on telomeric data for human prognosis.
CI  - Copyright (c) 2022 Peretz, Kupiec and Sharan.
FAU - Peretz, Iftah
AU  - Peretz I
AD  - The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel 
      Aviv, Israel.
FAU - Kupiec, Martin
AU  - Kupiec M
AD  - The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel 
      Aviv, Israel.
FAU - Sharan, Roded
AU  - Sharan R
AD  - Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20221104
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC9672475
OTO - NOTNLM
OT  - Saccharomyces cerevisiae (Baker's yeast)
OT  - Schizosaccharomyces pombe (fission yeast)
OT  - genetic interactions
OT  - machine learning model (ML model)
OT  - pathways
OT  - protein complexes
OT  - telomere length maintenance (TLM)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/22 06:00
MHDA- 2022/11/22 06:01
PMCR- 2022/11/04
CRDT- 2022/11/21 04:11
PHST- 2022/08/31 00:00 [received]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/21 04:11 [entrez]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2022/11/22 06:01 [medline]
PHST- 2022/11/04 00:00 [pmc-release]
AID - 1033113 [pii]
AID - 10.3389/fgene.2022.1033113 [doi]
PST - epublish
SO  - Front Genet. 2022 Nov 4;13:1033113. doi: 10.3389/fgene.2022.1033113. eCollection 
      2022.