PMID- 36407271
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221122
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 10
DP  - 2022 Oct
TI  - Metformin Reduces the Incidence of Sensorineural Hearing Loss in Patients With 
      Type 2 Diabetes Mellitus: A Retrospective Chart Review.
PG  - e30406
LID - 10.7759/cureus.30406 [doi]
LID - e30406
AB  - Introduction and objectives Acquired sensorineural hearing loss (SNHL) has become 
      a critical societal issue in recent years. SNHL is considered a risk factor for 
      type 2 diabetes mellitus (T2DM). Metformin is commonly used to treat T2DM. 
      However, its effects on SNHL have not been reported yet. Hence, this study aimed 
      to evaluate the association between the use of metformin and SNHL incidence. 
      Patients and methods In this retrospective matched-cohort study, the medical 
      records of 1219 patients with T2DM aged >18 years from our hospital's inpatient 
      database from January 1, 2012, to December 31, 2019, were examined, and matched 
      cohorts were generated (76 patients receiving metformin and 76 not receiving 
      metformin). A multivariable logistic regression analysis was performed to 
      investigate the factors influencing the incidence of SNHL. Results After 
      adjustment by propensity matching, multivariable logistic regression analysis 
      revealed that the non-use of metformin increased the risk of developing SNHL 
      (odds ratio, 0.26; 95% confidence interval, 0.07-0.93; p = 0.03). Conclusions 
      This study demonstrated an association between the use of metformin and a reduced 
      incidence of SNHL among patients with T2DM.
CI  - Copyright (c) 2022, Miwa et al.
FAU - Miwa, Toru
AU  - Miwa T
AD  - Otolaryngology, Osaka Metropolitan University, Osaka, JPN.
FAU - Kita, Tomoko
AU  - Kita T
AD  - Otolaryngology-Head and Neck Surgery, Kyoto University, Kyoto, JPN.
FAU - Yamaguchi, Taro
AU  - Yamaguchi T
AD  - Laboratory of Pharmacology, Setsunan University, Osaka, JPN.
FAU - Sakamoto, Tatsunori
AU  - Sakamoto T
AD  - Otolaryngology, Faculty of Medicine, Shimane University, Shimane, JPN.
LA  - eng
PT  - Journal Article
DEP - 20221017
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9669516
OTO - NOTNLM
OT  - diabetes mellitus type 2
OT  - metformin
OT  - multivariate logistic regression analysis
OT  - propensity score matching (psm)
OT  - sensorineural (sn) hearing loss
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/11/22 06:00
MHDA- 2022/11/22 06:01
PMCR- 2022/10/17
CRDT- 2022/11/21 04:30
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/21 04:30 [entrez]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2022/11/22 06:01 [medline]
PHST- 2022/10/17 00:00 [pmc-release]
AID - 10.7759/cureus.30406 [doi]
PST - epublish
SO  - Cureus. 2022 Oct 17;14(10):e30406. doi: 10.7759/cureus.30406. eCollection 2022 
      Oct.