PMID- 36409583
OWN - NLM
STAT- MEDLINE
DCOM- 20230315
LR  - 20230527
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 35
IP  - 3
DP  - 2023 Mar 14
TI  - The thin line between conventional dendritic cells (cDCs) and group 3 innate 
      lymphoid cells (ILC3s) in the gut.
PG  - 107-121
LID - 10.1093/intimm/dxac054 [doi]
AB  - Dendritic cells (DCs) express major histocompatibility complex class II (MHC-II) 
      and are best known for proficiently presenting antigens to T cells, thereby 
      eliciting specific adaptive T cell responses. Moreover, conventional DCs (cDCs) 
      are specifically adept at handling intestinal antigens. Relatively recent 
      discoveries and investigations have proven the existence of a new group of innate 
      lymphocytes that reside in tissues like the intestine. They lack specific antigen 
      receptors and can express MHC-II. These group 3 innate lymphoid cells (ILC3s) 
      comprise a subset of heterogeneous innate lymphocytes that mirror the phenotype 
      and functions of T-helper cells and act in the first line of defense. Considering 
      that ILC3s are crucial for maintaining homeostasis of the intestinal mucosa and 
      are found in niches alongside DCs, we herein describe the roles played by cDCs 
      and ILC3s in the gut, highlighting the most recent studies. We discuss how these 
      cells are alike and differ, constantly pointing out the thin, blurry line that 
      separates cDCs and ILC3s.
CI  - Published by Oxford University Press on behalf of The Japanese Society for 
      Immunology 2022.
FAU - Ulezko Antonova, Alina
AU  - Ulezko Antonova A
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      Saint Louis, MO 63108, USA.
FAU - Fachi, Jose Luis
AU  - Fachi JL
AUID- ORCID: 0000-0002-1035-5193
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      Saint Louis, MO 63108, USA.
FAU - Gilfillan, Susan
AU  - Gilfillan S
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      Saint Louis, MO 63108, USA.
FAU - Colonna, Marco
AU  - Colonna M
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      Saint Louis, MO 63108, USA.
LA  - eng
GR  - U01 AI095542/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Lymphocytes
MH  - *Immunity, Innate
MH  - Dendritic Cells
MH  - Histocompatibility Antigens Class II
MH  - Intestinal Mucosa
PMC - PMC10210749
OTO - NOTNLM
OT  - antigen presentation
OT  - colitis
OT  - microbiota
EDAT- 2022/11/22 06:00
MHDA- 2023/03/16 06:00
PMCR- 2022/11/21
CRDT- 2022/11/21 12:32
PHST- 2022/11/07 00:00 [received]
PHST- 2022/11/19 00:00 [accepted]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2023/03/16 06:00 [medline]
PHST- 2022/11/21 12:32 [entrez]
PHST- 2022/11/21 00:00 [pmc-release]
AID - 6835623 [pii]
AID - dxac054 [pii]
AID - 10.1093/intimm/dxac054 [doi]
PST - ppublish
SO  - Int Immunol. 2023 Mar 14;35(3):107-121. doi: 10.1093/intimm/dxac054.