PMID- 36410470
OWN - NLM
STAT- MEDLINE
DCOM- 20230327
LR  - 20230410
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 248
DP  - 2023 Apr
TI  - Cytokines Associated With Onset of a Hypertensive Phase and Surgical Failure 
      After Ahmed Glaucoma Valve Implantation.
PG  - 24-34
LID - S0002-9394(22)00435-4 [pii]
LID - 10.1016/j.ajo.2022.11.012 [doi]
AB  - PURPOSE: To investigate the relationship between cytokines of the aqueous humor 
      or Tenon capsule, the onset of a hypertensive phase, and surgical failure in 
      patients undergoing Ahmed Glaucoma Valve (AGV) implantation DESIGN: Prospective 
      clinical cohort study. METHODS: A total of 36 patients who underwent AGV 
      implantation were included. Samples of aqueous humor and Tenon tissue were 
      collected at the time of surgery. Multiple cytokines were evaluated in the 
      samples using a bead-based multiplex cytokine assay. As for surgical outcomes, a 
      hypertensive phase was defined as an intraocular pressure (IOP) of greater than 
      21 mm Hg within 3 months after surgery, whereas surgical failure was defined as 
      an IOP greater than 21 mm Hg with maximum tolerable glaucoma medications during 2 
      consecutive visits. RESULTS: Patients who entered a hypertensive phase showed 
      higher transforming growth factor-beta2 (TGF-beta2) levels in the aqueous humor 
      (P = .012). A longer axial length and higher TGF-beta2 concentration of the aqueous 
      humor were associated with higher maximum IOP values during 3 months after 
      surgery per multiple regression analysis (P = .028 and P = .034). In the multiple 
      logistic regression analysis, higher monocyte chemoattractant protein-1 (MCP-1) 
      concentrations in the aqueous humor and higher interleukin-4 concentrations in 
      Tenon tissue were related to surgical failure (P = .022 and P = .040). 
      CONCLUSIONS: Greater concentrations of TGF-beta2 and MCP-1 were related to surgical 
      outcome after glaucoma drainage device implantation. Further studies are needed 
      to confirm that down-regulation of these cytokines could be helpful in improving 
      surgical outcomes.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Jung, Kyoung In
AU  - Jung KI
AD  - From the Department of Ophthalmology, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Lee, Jihye
AU  - Lee J
AD  - From the Department of Ophthalmology, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Hong, Kyung Euy
AU  - Hong KE
AD  - From the Department of Ophthalmology, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Lee, Jiyun
AU  - Lee J
AD  - From the Department of Ophthalmology, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Park, Chan Kee
AU  - Park CK
AD  - From the Department of Ophthalmology, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address: 
      ckpark@catholic.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221121
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Transforming Growth Factor beta2)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - Transforming Growth Factor beta2/therapeutic use
MH  - Cytokines
MH  - Prospective Studies
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - *Glaucoma
MH  - Intraocular Pressure
MH  - *Glaucoma Drainage Implants
MH  - Prosthesis Implantation
MH  - Treatment Outcome
MH  - Retrospective Studies
EDAT- 2022/11/22 06:00
MHDA- 2023/03/28 06:00
CRDT- 2022/11/21 19:34
PHST- 2021/12/01 00:00 [received]
PHST- 2022/11/09 00:00 [revised]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2023/03/28 06:00 [medline]
PHST- 2022/11/21 19:34 [entrez]
AID - S0002-9394(22)00435-4 [pii]
AID - 10.1016/j.ajo.2022.11.012 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2023 Apr;248:24-34. doi: 10.1016/j.ajo.2022.11.012. Epub 2022 
      Nov 21.