PMID- 36411054
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20221222
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 9
IP  - 6
DP  - 2022 Nov-Dec
TI  - Neural Networks Implicated in Autobiographical Memory Training.
LID - ENEURO.0137-22.2022 [pii]
LID - 10.1523/ENEURO.0137-22.2022 [doi]
AB  - Training of autobiographical memory has been proposed as an intervention to 
      improve cognitive function. The neural substrates for such improvements are 
      poorly understood. Several brain areas have been previously linked to 
      autobiographical recollection, including structures in the default mode network 
      (DMN) and the sensorimotor network. Here, we tested the hypothesis that changes 
      in connectivity within different neural networks support distinct aspects of 
      memory improvement in response to training on a group of 59 human subjects. We 
      found that memory training using olfactory cues increases resting-state 
      intranetwork DMN connectivity, and this associates with improved recollection of 
      cue-specific memories. On the contrary, training decreased resting-state 
      connectivity within the sensorimotor network, a decrease that correlated with 
      improved ability for voluntary recall. Moreover, preliminary data indicate that 
      only the decrease in sensorimotor connectivity associated with the 
      training-induced decrease in the tumor necrosis factor alpha (TNFalpha) factor, an immune 
      modulation previously linked to improved cognitive performance. We identified 
      functional and biochemical factors that associate with distinct memory processes 
      improved by autobiographical training. Pathways which connect autobiographical 
      memory with both high-level cognition and somatic physiology are discussed.
CI  - Copyright (c) 2022 Cirneci et al.
FAU - Cirneci, Dragos
AU  - Cirneci D
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
AD  - Medical Imaging Department, Clinical Hospital Prof. Drive Th. Burghele, 
      Bucharest, 061344, Romania.
FAU - Onu, Mihaela
AU  - Onu M
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
AD  - Medical Imaging Department, Clinical Hospital Prof. Drive Th. Burghele, 
      Bucharest, 061344, Romania.
FAU - Papasteri, Claudiu C
AU  - Papasteri CC
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
AD  - Department of Psychology, University of Bucharest, Bucharest, 050657, Romania.
FAU - Georgescu, Dana
AU  - Georgescu D
AD  - Provita Medical Center, Bucharest, 011403, Romania.
FAU - Poalelungi, Catalina
AU  - Poalelungi C
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
FAU - Sofonea, Alexandra
AU  - Sofonea A
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
FAU - Puscasu, Nicoleta
AU  - Puscasu N
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
FAU - Tanase, Dumitru
AU  - Tanase D
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
FAU - Radeanu, Teofila
AU  - Radeanu T
AD  - Medical Imaging Department, Clinical Hospital Prof. Drive Th. Burghele, 
      Bucharest, 061344, Romania.
FAU - Toader, Maria-Yaelle
AU  - Toader MY
AD  - Medical Imaging Department, Clinical Hospital Prof. Drive Th. Burghele, 
      Bucharest, 061344, Romania.
FAU - Dogaru, Andreea L
AU  - Dogaru AL
AD  - Medical Imaging Department, Clinical Hospital Prof. Drive Th. Burghele, 
      Bucharest, 061344, Romania.
FAU - Podina, Ioana R
AU  - Podina IR
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
AD  - Department of Psychology, University of Bucharest, Bucharest, 050657, Romania.
FAU - Berceanu, Alexandru I
AU  - Berceanu AI
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania.
FAU - Carcea, Ioana
AU  - Carcea I
AD  - CINETic Center, University of Theatre and Film "I.L. Caragiale" Bucharest, 
      Bucharest, 020941, Romania ioana.carcea@rutgers.edu.
AD  - Department of Pharmacology, Physiology and Neuroscience, Rutgers Brain Health 
      Institute, Rutgers, The State University of New Jersey, Newark, NJ, 07103.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221130
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
SB  - IM
MH  - Humans
MH  - *Memory, Episodic
MH  - Mental Recall
MH  - Neural Networks, Computer
MH  - Cognition
MH  - Cues
PMC - PMC9718351
OTO - NOTNLM
OT  - autobiographical memory
OT  - memory training
OT  - neural networks
EDAT- 2022/11/22 06:00
MHDA- 2022/12/03 06:00
PMCR- 2022/11/30
CRDT- 2022/11/21 21:22
PHST- 2022/03/30 00:00 [received]
PHST- 2022/11/07 00:00 [revised]
PHST- 2022/11/11 00:00 [accepted]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/11/21 21:22 [entrez]
PHST- 2022/11/30 00:00 [pmc-release]
AID - ENEURO.0137-22.2022 [pii]
AID - eN-NWR-0137-22 [pii]
AID - 10.1523/ENEURO.0137-22.2022 [doi]
PST - epublish
SO  - eNeuro. 2022 Nov 30;9(6):ENEURO.0137-22.2022. doi: 10.1523/ENEURO.0137-22.2022. 
      Print 2022 Nov-Dec.