PMID- 36411495
OWN - NLM
STAT- MEDLINE
DCOM- 20221230
LR  - 20230103
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 68
IP  - 1
DP  - 2023 Jan
TI  - Effects of 3,4-methylenedioxymethamphetamine and methamphetamine on motor vehicle 
      driving performance: A systematic review of experimental and observational 
      studies.
PG  - 22-34
LID - 10.1111/1556-4029.15179 [doi]
AB  - Methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) are common 
      drugs of abuse and driving under their influence may occur in 1 million people 
      yearly in the United States. This systematic review fills the currently unmet 
      need in understanding the effects of METH and MDMA on motor vehicle driving 
      performance (MVP) and provides insight into the forensic community. A PubMed 
      search on September 24, 2020, for experimental and observational studies, which 
      evaluated the impact of METH and MDMA on MVP was performed. After a review of 208 
      abstracts, 103 were considered potentially interesting and full texts were 
      obtained. After the exclusion of non-English articles, review articles, single 
      case reports, and articles which did not evaluate METH or MDMA on MVP, a total of 
      nine experimental studies, 10 traditional observational studies, and 35 case 
      series were included. The clinical rigor of experimental studies was evaluated 
      using the Jadad scale. Experimental studies often demonstrated no significant MVP 
      safety signals for METH or MDMA use, which was contrary to the overwhelming MVP 
      safety risks found in observational studies. Common driving behaviors while using 
      METH or MDMA include: errors in judgment, traveling at high speeds, failure to 
      stop, merging inappropriately, lane weaving, and crashes. Limitations of 
      experimental studies that led to dissimilar MVP outcomes from observational 
      studies include: the common use of driving simulators, as opposed to actual 
      driving examinations, and doses of METH or MDMA administered may not be 
      representative of blood concentrations seen in observational studies. This 
      systematic review has no funding source and was not registered.
CI  - (c) 2022 American Academy of Forensic Sciences.
FAU - McGrane, Ian R
AU  - McGrane IR
AUID- ORCID: 0000-0002-9889-7260
AD  - Skaggs School of Pharmacy, College of Health, University of Montana, Missoula, 
      Montana, USA.
AD  - Department of Pharmacy, Providence St. Patrick Hospital, Missoula, Montana, USA.
FAU - Ramsbacher, Nathan C
AU  - Ramsbacher NC
AUID- ORCID: 0000-0001-9114-5624
AD  - Department of Pharmacy, Providence St. Patrick Hospital, Missoula, Montana, USA.
FAU - Rook, William C
AU  - Rook WC
AUID- ORCID: 0000-0001-8550-4846
AD  - Department of Pharmacy, University Hospitals Cleveland Medical Center, Cleveland, 
      Ohio, USA.
FAU - Omar, Faddy A
AU  - Omar FA
AUID- ORCID: 0000-0003-4752-1914
AD  - Department of Pharmacy, Holy Rosary Healthcare, Miles City, Montana, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20221121
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Humans
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Methamphetamine
MH  - Motor Vehicles
OTO - NOTNLM
OT  - 3,4-methylenedioxymethamphetamine
OT  - MDMA
OT  - amphetamines
OT  - driving
OT  - methamphetamine
OT  - motor vehicle
OT  - psychomotor function
OT  - psychostimulant
EDAT- 2022/11/22 06:00
MHDA- 2022/12/31 06:00
CRDT- 2022/11/21 23:52
PHST- 2022/10/29 00:00 [revised]
PHST- 2022/09/07 00:00 [received]
PHST- 2022/11/15 00:00 [accepted]
PHST- 2022/11/22 06:00 [pubmed]
PHST- 2022/12/31 06:00 [medline]
PHST- 2022/11/21 23:52 [entrez]
AID - 10.1111/1556-4029.15179 [doi]
PST - ppublish
SO  - J Forensic Sci. 2023 Jan;68(1):22-34. doi: 10.1111/1556-4029.15179. Epub 2022 Nov 
      21.