PMID- 36413073
OWN - NLM
STAT- MEDLINE
DCOM- 20230708
LR  - 20240320
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 62
IP  - 7
DP  - 2023 Jul 5
TI  - Safety and tolerance of vaccines against SARS-CoV-2 infection in systemic lupus 
      erythematosus: results from the COVAD study.
PG  - 2453-2463
LID - 10.1093/rheumatology/keac661 [doi]
AB  - OBJECTIVE: To determine COVID-19 vaccine-related adverse events (AEs) in the 
      seven-day post-vaccination period in patients with SLE vs autoimmune rheumatic 
      diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy 
      controls (HC). METHODS: Data were captured through the COVID-19 Vaccination in 
      Autoimmune Diseases (COVAD) questionnaire (March-December 2021). Multivariable 
      regression models accounted for age, gender, ethnicity, vaccine type and 
      background treatment. RESULTS: Among 9462 complete respondents, 583 (6.2%) were 
      SLE patients (mean age: 40.1 years; 94.5% females; 40.5% Asian; 42.9% 
      Pfizer-recipients). Minor AEs were reported by 83.0% of SLE patients, major by 
      2.6%, hospitalization by 0.2%. AE and hospitalization frequencies were similar 
      between patients with active and inactive SLE. Rashes were more frequent in SLE 
      patients vs HC (OR; 95% CI: 1.2; 1.0, 1.5), chills less frequent in SLE vs AIRDs 
      (0.6; 0.4, 0.8) and nrAIDs (0.5; 0.3, 0.8), and fatigue less frequent in SLE vs 
      nrAIDs (0.6; 0.4, 0.9). Pfizer-recipients reported higher overall AE (2.2; 1.1, 
      4.2) and injection site pain (2.9; 1.6, 5.0) frequencies than recipients of other 
      vaccines, Oxford/AstraZeneca-recipients more body ache, fever, chills (OR: 2.5, 
      3.0), Moderna-recipients more body ache, fever, chills, rashes (OR: 2.6, 4.3). 
      Hospitalization frequencies were similar across vaccine types. AE frequencies 
      were similar across treatment groups, although chills were less frequent in 
      antimalarial users vs non-users (0.5; 0.3, 0.9). CONCLUSION: While COVID-19 
      vaccination-related AEs were reported by four-fifths of SLE patients, those were 
      mostly minor and comparable to AEs reported by healthy individuals, providing 
      reassurance regarding COVID-19 vaccination safety in SLE.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology.
FAU - Naveen, R
AU  - Naveen R
AUID- ORCID: 0000-0003-2014-3925
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate 
      Institute of Medical Sciences, Lucknow, India.
FAU - Nikiphorou, Elena
AU  - Nikiphorou E
AD  - Centre for Rheumatic Diseases, King's College London, London, UK.
AD  - Rheumatology Department, King's College Hospital, London, UK.
FAU - Joshi, Mrudula
AU  - Joshi M
AD  - Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, 
      Pune, India.
FAU - Sen, Parikshit
AU  - Sen P
AD  - Maulana Azad Medical College, New Delhi, Delhi, India.
FAU - Lindblom, Julius
AU  - Lindblom J
AD  - Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and 
      Karolinska University Hospital, Stockholm, Sweden.
FAU - Agarwal, Vishwesh
AU  - Agarwal V
AD  - Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India.
FAU - Lilleker, James B
AU  - Lilleker JB
AUID- ORCID: 0000-0002-9230-4137
AD  - Centre for Musculoskeletal Research, Division of Musculoskeletal and 
      Dermatological Sciences, School of Biological Sciences, Faculty of Biology, 
      Medicine and Health, Manchester Academic Health Science Centre, The University of 
      Manchester, Manchester, UK.
AD  - Neurology, Manchester Centre for Clinical Neurosciences, Northern Care Alliance 
      NHS Foundation Trust, Salford, UK.
FAU - Tan, Ai Lyn
AU  - Tan AL
AUID- ORCID: 0000-0002-9158-7243
AD  - NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
AD  - Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 
      Leeds, UK.
FAU - Salim, Babur
AU  - Salim B
AD  - Rheumatology Department, Fauji Foundation Hospital, Rawalpindi, Pakistan.
FAU - Ziade, Nelly
AU  - Ziade N
AUID- ORCID: 0000-0002-4479-7678
AD  - Rheumatology Department, Saint-Joseph University, Beirut, Lebanon.
AD  - Rheumatology Department, Hotel-Dieu de France Hospital, Beirut, Lebanon.
FAU - Velikova, Tsvetelina
AU  - Velikova T
AD  - Department of Clinical Immunology, Medical Faculty, University Hospital 
      'Lozenetz', Sofia University St. Kliment Ohridski, Sofia, Bulgaria.
FAU - Gracia-Ramos, Abraham Edgar
AU  - Gracia-Ramos AE
AUID- ORCID: 0000-0003-1842-2554
AD  - Department of Internal Medicine, General Hospital, National Medical Center, 'La 
      Raza', Instituto Mexicano del Seguro Social, Mexico City, Mexico.
FAU - Kuwana, Masataka
AU  - Kuwana M
AUID- ORCID: 0000-0001-8352-6136
AD  - Department of Allergy and Rheumatology, Nippon Medical School Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Day, Jessica
AU  - Day J
AUID- ORCID: 0000-0001-8528-4361
AD  - Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, Australia.
AD  - Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
AD  - Department of Medical Biology, University of Melbourne, Parkville, VIC, 
      Australia.
FAU - Makol, Ashima
AU  - Makol A
AD  - Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
FAU - Distler, Oliver
AU  - Distler O
AUID- ORCID: 0000-0002-0546-8310
AD  - Department of Rheumatology, University Hospital Zurich, University of Zurich, 
      Zurich, Switzerland.
FAU - Chinoy, Hector
AU  - Chinoy H
AUID- ORCID: 0000-0001-6492-1288
AD  - Centre for Musculoskeletal Research, Division of Musculoskeletal and 
      Dermatological Sciences, School of Biological Sciences, Faculty of Biology, 
      Medicine and Health, Manchester Academic Health Science Centre, The University of 
      Manchester, Manchester, UK.
AD  - National Institute for Health Research Manchester Biomedical Research Centre, 
      Manchester University NHS Foundation Trust, The University of Manchester, 
      Manchester, UK.
AD  - Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS 
      Foundation Trust, Salford, UK.
FAU - Traboco, Lisa S
AU  - Traboco LS
AD  - Department of Medicine, Section of Rheumatology, St. Luke's Medical Center-Global 
      City, Taguig, Philippines.
FAU - Wibowo, Suryo Anggoro Kusumo
AU  - Wibowo SAK
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Universitas Indonesia/Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
FAU - Tehozol, Erick Adrian Zamora
AU  - Tehozol EAZ
AD  - Autoimmunity Division, Centro Medico Pensiones, Merida, Yucatan, Mexico.
FAU - Serrano, Jorge Rojas
AU  - Serrano JR
AD  - Rheumatologist and Clinical Investigator, Interstitial Lung Disease and 
      Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, 
      Mexico.
FAU - Garcia-De La Torre, Ignacio
AU  - Garcia-De La Torre I
AD  - Departamento de Inmunologia y Reumatologia, Hospital General de Occidente and 
      University of Guadalajara, Guadalajara, Jalisco, Mexico.
CN  - COVAD Study Group
FAU - Aggarwal, Rohit
AU  - Aggarwal R
AD  - Division of Rheumatology and Clinical Immunology, University of Pittsburgh School 
      of Medicine, Pittsburgh, PA, USA.
FAU - Gupta, Latika
AU  - Gupta L
AUID- ORCID: 0000-0003-2753-2990
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate 
      Institute of Medical Sciences, Lucknow, India.
AD  - Centre for Musculoskeletal Research, Division of Musculoskeletal and 
      Dermatological Sciences, School of Biological Sciences, Faculty of Biology, 
      Medicine and Health, Manchester Academic Health Science Centre, The University of 
      Manchester, Manchester, UK.
AD  - Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, 
      Wolverhampton, UK.
AD  - City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
FAU - Agarwal, Vikas
AU  - Agarwal V
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate 
      Institute of Medical Sciences, Lucknow, India.
FAU - Parodis, Ioannis
AU  - Parodis I
AUID- ORCID: 0000-0002-4875-5395
AD  - Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and 
      Karolinska University Hospital, Stockholm, Sweden.
AD  - Department of Rheumatology, Faculty of Medicine and Health, Orebro University, 
      Orebro, Sweden.
LA  - eng
GR  - 21992/VAC_/Versus Arthritis/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Vaccines)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - *Autoimmune Diseases
MH  - Chills
MH  - *COVID-19/prevention & control
MH  - *COVID-19 Vaccines/adverse effects
MH  - *Exanthema
MH  - *Lupus Erythematosus, Systemic
MH  - SARS-CoV-2
MH  - Vaccination/adverse effects
MH  - *Vaccines
PMC - PMC10321116
OTO - NOTNLM
OT  - COVID-19
OT  - adverse events
OT  - rheumatology
OT  - systemic lupus erythematosus
OT  - vaccine
FIR - Barman, Bhupen
IR  - Barman B
FIR - Singh, Yogesh Preet
IR  - Singh YP
FIR - Ranjan, Rajiv
IR  - Ranjan R
FIR - Jain, Avinash
IR  - Jain A
FIR - Pandya, Sapan C
IR  - Pandya SC
FIR - Pilania, Rakesh Kumar
IR  - Pilania RK
FIR - Sharma, Aman
IR  - Sharma A
FIR - Manesh Manoj, M
IR  - Manesh Manoj M
FIR - Gupta, Vikas
IR  - Gupta V
FIR - Kavadichanda, Chengappa G
IR  - Kavadichanda CG
FIR - Patro, Pradeepta Sekhar
IR  - Patro PS
FIR - Ajmani, Sajal
IR  - Ajmani S
FIR - Phatak, Sanat
IR  - Phatak S
FIR - Goswami, Rudra Prosad
IR  - Goswami RP
FIR - Chowdhury, Abhra Chandra
IR  - Chowdhury AC
FIR - Mathew, Ashish Jacob
IR  - Mathew AJ
FIR - Shenoy, Padnamabha
IR  - Shenoy P
FIR - Asranna, Ajay
IR  - Asranna A
FIR - Bommakanti, Keerthi Talari
IR  - Bommakanti KT
FIR - Shukla, Anuj
IR  - Shukla A
FIR - Pandey, Arun Kumar R
IR  - Pandey AKR
FIR - Chandwar, Kunal
IR  - Chandwar K
FIR - Kardes, Sinan
IR  - Kardes S
FIR - Cansu, Dondu Uskudar
IR  - Cansu DU
FIR - Kim, Minchul
IR  - Kim M
FIR - Makol, Ashima
IR  - Makol A
FIR - Chatterjee, Tulika
IR  - Chatterjee T
FIR - Pauling, John D
IR  - Pauling JD
FIR - Wincup, Chris
IR  - Wincup C
FIR - Cavagna, Lorenzo
IR  - Cavagna L
FIR - Del Papa, Nicoletta
IR  - Del Papa N
FIR - Sambataro, Gianluca
IR  - Sambataro G
FIR - Fabiola, Atzeni
IR  - Fabiola A
FIR - Govoni, Marcello
IR  - Govoni M
FIR - Parisi, Simone
IR  - Parisi S
FIR - Bocci, Elena Bartoloni
IR  - Bocci EB
FIR - Sebastiani, Gian Domenico
IR  - Sebastiani GD
FIR - Fusaro, Enrico
IR  - Fusaro E
FIR - Sebastiani, Marco
IR  - Sebastiani M
FIR - Quartuccio, Luca
IR  - Quartuccio L
FIR - Franceschini, Franco
IR  - Franceschini F
FIR - Sainaghi, Pier Paolo
IR  - Sainaghi PP
FIR - Orsolini, Giovanni
IR  - Orsolini G
FIR - De Angelis, Rossella
IR  - De Angelis R
FIR - Danielli, Maria Giovanna
IR  - Danielli MG
FIR - Venerito, Vincenzo
IR  - Venerito V
FIR - Milchert, Marcin
IR  - Milchert M
FIR - Traboco, Lisa S
IR  - Traboco LS
FIR - Wibowo, Suryo Anggoro Kusumo
IR  - Wibowo SAK
FIR - Tehozol, Erick Adrian Zamora
IR  - Tehozol EAZ
FIR - Serrano, Jorge Rojas
IR  - Serrano JR
FIR - Garcia-De La Torre, Ignacio
IR  - Garcia-De La Torre I
FIR - Loarce-Martos, Jesus
IR  - Loarce-Martos J
FIR - Prieto-Gonzalez, Sergio
IR  - Prieto-Gonzalez S
FIR - Gil-Vila, Albert
IR  - Gil-Vila A
FIR - Gonzalez, Raquel Aranega
IR  - Gonzalez RA
FIR - Kuwana, Masataka
IR  - Kuwana M
FIR - Yoshida, Akira
IR  - Yoshida A
FIR - Nakashima, Ran
IR  - Nakashima R
FIR - Sato, Shinji
IR  - Sato S
FIR - Kimura, Naoki
IR  - Kimura N
FIR - Kaneko, Yuko
IR  - Kaneko Y
FIR - Knitza, Johannes
IR  - Knitza J
FIR - Tomaras, Stylianos
IR  - Tomaras S
FIR - Gromova, Margarita Aleksandrovna
IR  - Gromova MA
FIR - Aharonov, Or
IR  - Aharonov O
FIR - Gheita, Tamer A
IR  - Gheita TA
FIR - Hmamouchi, Ihsane
IR  - Hmamouchi I
FIR - Hoff, Leonardo Santos
IR  - Hoff LS
FIR - Giannini, Margherita
IR  - Giannini M
FIR - Maurier, Francois
IR  - Maurier F
FIR - Campagne, Julien
IR  - Campagne J
FIR - Meyer, Alain
IR  - Meyer A
FIR - Nagy-Vincze, Melinda
IR  - Nagy-Vincze M
FIR - Langguth, Daman
IR  - Langguth D
FIR - Limaye, Vidya
IR  - Limaye V
FIR - Needham, Merrilee
IR  - Needham M
FIR - Srivastav, Nilesh
IR  - Srivastav N
FIR - Hudson, Marie
IR  - Hudson M
FIR - Landon-Cardinal, Oceane
IR  - Landon-Cardinal O
FIR - Shaharir, Syahrul Sazliyana
IR  - Shaharir SS
FIR - Zuleta, Wilmer Gerardo Rojas
IR  - Zuleta WGR
FIR - Silva, Jose Antonio Pereira
IR  - Silva JAP
FIR - Fonseca, Joao Eurico
IR  - Fonseca JE
FIR - Zimba, Olena
IR  - Zimba O
EDAT- 2022/11/23 06:00
MHDA- 2023/07/07 06:42
PMCR- 2022/11/22
CRDT- 2022/11/22 09:23
PHST- 2022/09/16 00:00 [received]
PHST- 2022/11/10 00:00 [accepted]
PHST- 2023/07/07 06:42 [medline]
PHST- 2022/11/23 06:00 [pubmed]
PHST- 2022/11/22 09:23 [entrez]
PHST- 2022/11/22 00:00 [pmc-release]
AID - 6839954 [pii]
AID - keac661 [pii]
AID - 10.1093/rheumatology/keac661 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2023 Jul 5;62(7):2453-2463. doi: 
      10.1093/rheumatology/keac661.